Articles tagged "Lymphocytes"

2022 American Transplant Congress
Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients
H. L. Mai¹, N. Degauque¹, S. Le Bot¹, M. Rimbert¹, K. Renaudin¹, R. Danger¹, F. Le Borgne², C. Kerleau¹, F. Delbos³, M. Giral¹, S. Brouard¹
¹UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, ²UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, ³Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France
*Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
2022 American Transplant Congress
Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro⁵, J. Pawlowska¹⁰, R. Mikolajczyk¹¹, U. Baumann¹², C. Falk¹³
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹¹German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹²Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, ¹³Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
2022 American Transplant Congress
Multidimensional Immunological Profiling of CMV Dnaemia in Kidney Transplant Recipients
H. Pickering¹, S. Sen², R. S. Ahn², Z. Qian¹, G. Sunga¹, M. LLamas¹, A. Hoffmann¹, M. Deng¹, S. Bunnapradist³, J. Schaenman⁴, D. W. Gjertson¹, M. Rossetti¹, E. Reed⁵
¹UCLA, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA, ³David Geffen School of Medicine, Los Angeles, CA, ⁴David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁵Univ of California LA, Los Angeles, CA
*Purpose: Human cytomegalovirus (CMV) infects over half the global population, leading to a mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals…
2022 American Transplant Congress
Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade
K. L. Alexander, D. Liu, M. L. Ford
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: CD154 pathway antagonism has shown to be a promising target for inducing long-time graft survival, in some cases showing efficacy that is superior to…
2022 American Transplant Congress
Longitudinal Analysis of the Lung Microbiome and Immune Status in Lung Transplant Recipients
Y. Zhao, P. Zhang, Y. Su, Y. Zhu, L. Shen
Shanghai Pulmonary Hospital, Shanghai, China
*Purpose: The dynamic remodeling of lung flora structure and the association between microbial community dynamics and immune status after lung transplantation (LTx) remain unclear.*Methods: Fourteen…
2022 American Transplant Congress
Combined CyTOF and Elispot Investigation of CMV Response Over the First Year Post Kidney Transplantation
T. Jouve¹, L. Donadeu Casassas², S. Hartzell³, E. Crespo², M. Meneghini², A. Torija², P. Cravedi⁴, O. Bestard²
¹Nephrology, Vall d’Hebron Institut de Recerca (VHIR), Grenoble, Spain, ²Nephrology, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ³Mount Sinai Hospital, New York, NY, ⁴Mount Sinai, New York, NY
*Purpose: CMV remains a threat for kidney transplant recipients (KTR). Deciphering the impact of CMV on the immune system of KTR has helped improving CMV…
2022 American Transplant Congress
PTLD Suspected by Visualization of Atypical Urinary Lymphocytes
J. Huidobro E¹, F. Anghileri², P. Troncoso³, A. Huete⁴, P. Downey¹
¹Nephrology, Pontificia Universidad Catolica de Chile, Santiago, Chile, ²Clinical Laboratories, Pontificia Universidad Catolica de Chile, Santiago, Chile, ³Urology, Pontificia Universidad Catolica de Chile, Santiago, Chile, ⁴Radiology, Pontificia Universidad Catolica de Chile, Santiago, Chile
*Purpose: Urinalysis has been used for the detection of acute rejection but visualization of atypical lymphocytes in the urine sediment as an early sign of…
2022 American Transplant Congress
The Impact of Yttium-90 Radioembolization on T Cell Phenotypes in Bridged to Transplant Hepatocellular Carcinoma Patients
K. Nunez, T. Sandow, P. Thevenot, A. Cohen
Ochsner Health System, New Orleans, LA
*Purpose: Response to locoregional therapy (LRT) in hepatocellular carcinoma (HCC) impacts both progression-free survival (PFS) and bridge to transplant success. Yttrium-90 (Y90) is an effective…
2022 American Transplant Congress
Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient
O. C. Onuh¹, J. Trilles¹, W. J. Rifkin¹, H. Brydges¹, B. F. Chaya¹, R. Rodriguez Colon¹, D. Boczar¹, D. J. Ceradini¹, E. D. Rodriguez¹, B. E. Gelb²
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
2022 American Transplant Congress
Obinutuzumab in Kidney Transplantation: Effect on B-cell Counts and Crossmatch Tests
M. M. Nasrallah¹, M. Elalfy¹, Y. Elmesseery², I. Amer¹, P. Malvezzi³, L. Rostaing⁴
¹Misr International Hospital, Cairo, Egypt, ²Misr International Hospital, Caire, Egypt, ³CHU Grenoble-Alpes, Grenoble, France, ⁴Service de Néphrologie, CHU Grenoble-Alpes, Grenoble, France
*Purpose: Resistance to the action of rituximab (RTX), has been documented in several diseases. More recently, obinutuzumab (OBZ) has shown promise where RTX has failed…

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