2016 American Transplant Congress
Hif-1α Stabilization in the Recipient Accelerates Cardiac Allograft Rejection.
Northwestern University, Chicago.
Introduction: Increased Hif-1α mRNA expression in deceased-donor organ transplant tissue prior to or soon after transplantation significantly correlated with primary graft dysfunction. HIF-1α is positioned…2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…2015 American Transplant Congress
Erythropoietin (EPO) Has Treg Sparing Immunosuppressive Effects On Human Alloreactive T Cells
Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Extending previous work showing that EPO inhibits alloreactive effector T cell proliferation by uncoupling IL2 receptor signaling (JASN 2014), we tested the effects of EPO…2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…2015 American Transplant Congress
Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations
Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…2015 American Transplant Congress
Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch
Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…2015 American Transplant Congress
Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection
【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…2015 American Transplant Congress
The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells
Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…
American Transplant Congress abstracts