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American Transplant Congress abstracts

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Articles tagged "Lymphocyte activation"

  • 2016 American Transplant Congress

    Rapid Detection of Urinary CXCL9 as a Diagnostic and Prognostic Tool for Managing Acute Cellular Rejection (ACR) in Kidney Transplantation.

    I. Gandolfini,1 C. Harris,1 C. Purroy,1 V. Nair,1 J. Reid-Adam,1 O. Bestard,2 P. Heeger.1

    1Icahn School of Medicine at Mount Sinai, New York, NY; 2Bellvitge University Hospital, Barcelona, Spain.

    Urinary (u) CXCL9 protein expression can noninvasively diagnose ACR and serial measurements during CNI withdrawal indicate that elevations in uCXCL9 detect subclinical rejection. How elevated…
  • 2015 American Transplant Congress

    DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection

    J. Wedel, S. Bruneau, K. Liu, N. Kochupurakkal, M. Laplante, D. Briscoe.

    Transplant Research Program, Boston Children's Hospital, Boston, MA.

    DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…
  • 2015 American Transplant Congress

    Erythropoietin (EPO) Has Treg Sparing Immunosuppressive Effects On Human Alloreactive T Cells

    C. Purroy, P. Heeger, P. Cravedi.

    Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.

    Extending previous work showing that EPO inhibits alloreactive effector T cell proliferation by uncoupling IL2 receptor signaling (JASN 2014), we tested the effects of EPO…
  • 2015 American Transplant Congress

    Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells

    K. Samy, H. Xu, A. Kirk.

    Surgery, Duke University Medical Center, Durham, NC.

    Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
  • 2015 American Transplant Congress

    Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations

    J. Mathew, X. Huang, J. Leventhal, L. Gallon, J. Miller, J. Levitsky.

    Surgery - Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…
  • 2015 American Transplant Congress

    Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch

    M. Yap,1,3 G. Tilly,1,3 M. Giral,1,2 D.-A. Laplaud,1,2 S. Brouard,1,2 C. Pecqueur,4 N. Degauque.1,2

    1INSERM UMR1064, Nantes, France; 2CHU de Nantes, Nantes, France; 3University of Nantes, Nantes, France; 4INSERM UMR892, Nantes, France.

    Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…
  • 2015 American Transplant Congress

    Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

    S. Iida,1 T. Suzuki,2 K. Tanabe,1 A. Valujskikh,3 R. Fairchild,3 R. Abe.2

    1Urology, Tokyo Women's Medical Univ, Tokyo, Japan; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Immunology, Cleveland Clinic, Cleveland, OH.

    【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
  • 2015 American Transplant Congress

    The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells

    G. Stallone,1 R. Federica,1 P. Pontrelli,2 M. Accetturo,2 A. Oranger,2 M. Gigante,2 G. Castellano,2 A. Schena,2 M. Fiorentino,2 B. Infante,1 L. Gesualdo,2 G. Grandaliano.1

    1Dept.of Surgical and Medical Sciences, Nephrology Unit, University of Foggia, Foggia, Italy; 2Dept. of Emergency and Organ Transplantation, Nephrology Unit, University of Bari, Bari, Italy.

    Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…
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