2018 American Transplant Congress
Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival
Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…2018 American Transplant Congress
Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands
Transplant Surgery, University of Wisconsin, Madison, WI.
The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…2018 American Transplant Congress
TLR-Activated Bregs Promote Islet Allograft Tolerance in an IL-10-Independent and TGF-β-Dependent Manner
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We previously demonstrated the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. Recently, we produced TLR-activated B cells in vitro that…2018 American Transplant Congress
Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human
We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…2017 American Transplant Congress
Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.
Background: Our previous studies document the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. However, we have been largely unsuccessful in demonstrating…2017 American Transplant Congress
A Novel Method for iNKT Cell-Mediated Ex Vivo Treg Expansion Applied to Induce Human Transplant Tolerance.
Background: Although regulatory T cells (Tregs) are beneficial for transplant-tolerance induction, decisive methods for their preferential expansion have not yet been established. In our series…2017 American Transplant Congress
CMV-Infected Kidney Grafts Drive the Expansion of Blood-Born CMV-Specific T-Cells Restricted by Shared HLA Molecules Through Presentation on Donor's Cells.
Background. Cytomegalovirus specific immune response is crucial to control CMV infection in kidney transplant recipients (KTR), in whom recipient CMV can reactivated (R+) and donor…2017 American Transplant Congress
Glycolytic and Glutaminolytic Metabolism Supports IL-15 Induced Inflammatory Response of Temra CD8 from Kidney Transplant Recipients.
1CRTI UMR1064, INSERM, Nantes, France; 2CRCNA UMR892, INSERM, Nantes, France
Rational. We have recently shown that the accumulation of TEMRA CD8 in kidney transplant recipients (Tx) is associated with a higher risk of kidney dysfunction.…2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…2017 American Transplant Congress
Donor Lymphoid Chimerism in Early Recognition and Prediction of Clinical Outcome Caused by Acute Graft versus Host Disease After Solid Organ Transplant.
Introduction: Acute graft versus host disease (aGvHD) after solid organ transplant (SOT) is rare but related with high mortality. Early accurate diagnosis is critical for…
American Transplant Congress abstracts