Articles tagged "Lymphocyte activation"

2020 American Transplant Congress
Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation
A. Dangi¹, K. Glinton², M. Sharma¹, S. Yu¹, M. DeBerge², E. B. Thorp², X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Pathology, Northwestern University, Chicago, IL
*Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
Clinical Implication of Tertially Lymphoid Tissue in the Renal Graft
M. Saito¹, Y. Lee², Y. Sato², S. Narita¹, S. Satoh¹, M. Yanagita², T. Habuchi¹
¹Urology, Akita University Hospital, Akita, Japan, ²Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
*Purpose: Tertialy lymphoid organs (TLTs) are defined as inducible lymphoid tissues that arise in non-lymphoid organs, and chronic sustained inflammation is one of the most…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2019 American Transplant Congress
Targeting Cell Metabolism for Efficient Large-Scale Expansion of Functional Regulatory T Cells
R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi
University of Kentucky, Lexington, KY
*Purpose: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
2019 American Transplant Congress
Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor
D. Heja¹, Z. He¹, S. A. Lira¹, F. Lin², D. Homann¹, P. S. Heeger¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Cleveland Clinic, Cleveland, OH
*Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…
2019 American Transplant Congress
Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking
W. Piao¹, L. Li², V. Saxena², Y. Xiong², M. WillsonShirkey², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
2019 American Transplant Congress
mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells
J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan
Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
2019 American Transplant Congress
Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture
P. Rajendran¹, M. Cusick², S. Dhingra³, B. Murthy¹
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, ³Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…
2019 American Transplant Congress
Cellular And Molecular Characteristics Of Intra-graft Lymphoid Aggregates In Chronic Lung Allograft Dysfunction
E. Miyamoto¹, S. Juvet¹, D. Hwang², S. Keshavjee¹, T. Martinu¹
¹Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, ²Sunnybrook Health Sciences Centre, Toronto, ON, Canada
*Purpose: Lymphoid aggregates (LAs) have been identified within lung allografts post lung transplant (LTx). However, it remains controversial whether they represent benign lymphoid tissue or…