ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocyte activation"

  • 2020 American Transplant Congress

    Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation

    A. Dangi1, K. Glinton2, M. Sharma1, S. Yu1, M. DeBerge2, E. B. Thorp2, X. Luo1

    1Nephrology/Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL

    *Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…
  • 2020 American Transplant Congress

    Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver

    K. Carlson1, F. Najmabadi1, J. Pavan-Guimaraes1, W. J. Burlingham1, C. M. Capitini2, D. P. Al-Adra1

    1Surgery, University of Wisconsin, Madison, WI, 2Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI

    *Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
  • 2020 American Transplant Congress

    Clinical Implication of Tertially Lymphoid Tissue in the Renal Graft

    M. Saito1, Y. Lee2, Y. Sato2, S. Narita1, S. Satoh1, M. Yanagita2, T. Habuchi1

    1Urology, Akita University Hospital, Akita, Japan, 2Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    *Purpose: Tertialy lymphoid organs (TLTs) are defined as inducible lymphoid tissues that arise in non-lymphoid organs, and chronic sustained inflammation is one of the most…
  • 2020 American Transplant Congress

    Influence of Microbial Communities on Transplantation

    K. Janek1, J. Fechner1, K. Krautkramer2, S. Sudakaran3, J. Denu4, J. Handelsman3, F. Rey5, E. Vivas5, J. Mezrich1

    1Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Wisconsin Institute for Discovery, Madison, WI, 4Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 5Bacteriology, University of Wisconsin-Madison, Madison, WI

    *Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
  • 2019 American Transplant Congress

    Targeting Cell Metabolism for Efficient Large-Scale Expansion of Functional Regulatory T Cells

    R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi

    University of Kentucky, Lexington, KY

    *Purpose: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
  • 2019 American Transplant Congress

    Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor

    D. Heja1, Z. He1, S. A. Lira1, F. Lin2, D. Homann1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…
  • 2019 American Transplant Congress

    Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking

    W. Piao1, L. Li2, V. Saxena2, Y. Xiong2, M. WillsonShirkey2, C. Paluskievicz2, J. Bromberg3

    1Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, 2Surgery, U. Maryland, Baltimore, Baltimore, MD, 3Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
  • 2019 American Transplant Congress

    mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells

    J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan

    Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
  • 2019 American Transplant Congress

    Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture

    P. Rajendran1, M. Cusick2, S. Dhingra3, B. Murthy1

    1Baylor College of Medicine, Houston, TX, 2Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, 3Pathology, Baylor College of Medicine, Houston, TX

    *Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…
  • 2019 American Transplant Congress

    Cellular And Molecular Characteristics Of Intra-graft Lymphoid Aggregates In Chronic Lung Allograft Dysfunction

    E. Miyamoto1, S. Juvet1, D. Hwang2, S. Keshavjee1, T. Martinu1

    1Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, 2Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    *Purpose: Lymphoid aggregates (LAs) have been identified within lung allografts post lung transplant (LTx). However, it remains controversial whether they represent benign lymphoid tissue or…
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