Articles tagged "Lymphocyte activation"

2021 American Transplant Congress
P2X7 Receptor Activity Mediates Th17-Specific Self- and Alloreactivity in Non-Human Primates
C. Little, J. Sullivan, W. Burlingham, D. Kaufman
Department of Surgery, University of Wisconsin, Madison, WI
*Purpose: The broadly expressed ATP-binding purinergic receptor, P2X7 (P2X7R) is involved in the Th17 mediated cellular immune response to allo- and select self-antigens (Collagen type…
2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
J. Y. Choi¹, H. Nakagawa², Z. Solhjou¹, K. Yatim¹, H. Zhang³, P. Patel³, M. Tawfeek Mohammed³, L. Riella⁴, H. Kim², H. Cantor², J. Azzi¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ²Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
2021 American Transplant Congress
Detection of SARS-CoV-2 Specific Functional T Cells Using a Seven Color Flow Cytometry Assay
L. Flebbe-Rehwaldt, J. Hayden, K. Mickey, S. Manley, S. Kleiboeker
Eurofins-Viracor, Lees Summit, MO
*Purpose: The need to evaluate SARS-CoV-2 immune responses is an important clinical research focus. Detecting neutralizing antibodies is one measure of immune response, but the…
2021 American Transplant Congress
T Cell Repertoire Diversity in HCV-Associated Hepatocellular Carcinoma Patients Waitlisted for Liver Transplantation and Receiving Liver-Directed Therapy
K. Nunez, T. Sandow, A. Cohen, P. Thevenot
Ochsner Health, New Orleans, LA
*Purpose: T cell receptor (TCR) sequencing in hepatocellular carcinoma (HCC) patients revealed a diverse TCR repertoire in hepatitis B-associated HCC-infiltrating T cells. In this study,…
2020 American Transplant Congress
Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation
A. Dangi¹, K. Glinton², M. Sharma¹, S. Yu¹, M. DeBerge², E. B. Thorp², X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Pathology, Northwestern University, Chicago, IL
*Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
Clinical Implication of Tertially Lymphoid Tissue in the Renal Graft
M. Saito¹, Y. Lee², Y. Sato², S. Narita¹, S. Satoh¹, M. Yanagita², T. Habuchi¹
¹Urology, Akita University Hospital, Akita, Japan, ²Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
*Purpose: Tertialy lymphoid organs (TLTs) are defined as inducible lymphoid tissues that arise in non-lymphoid organs, and chronic sustained inflammation is one of the most…
2020 American Transplant Congress
Influence of Microbial Communities on Transplantation
K. Janek¹, J. Fechner¹, K. Krautkramer², S. Sudakaran³, J. Denu⁴, J. Handelsman³, F. Rey⁵, E. Vivas⁵, J. Mezrich¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Wisconsin Institute for Discovery, Madison, WI, ⁴Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, ⁵Bacteriology, University of Wisconsin-Madison, Madison, WI
*Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
2019 American Transplant Congress
Targeting Cell Metabolism for Efficient Large-Scale Expansion of Functional Regulatory T Cells
R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi
University of Kentucky, Lexington, KY
*Purpose: A growing body of evidence recognizes the balance between graft-reactive effector T cells and graft-protective regulatory T cells (Tregs) as the ultimate determinant of…
2019 American Transplant Congress
Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor
D. Heja¹, Z. He¹, S. A. Lira¹, F. Lin², D. Homann¹, P. S. Heeger¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Cleveland Clinic, Cleveland, OH
*Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…