ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocyte activation"

  • 2019 American Transplant Congress

    Regulating T Cell Responses by Forced Transgenic Expression of Decay-Accelerating Factor

    D. Heja1, Z. He1, S. A. Lira1, F. Lin2, D. Homann1, P. S. Heeger1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Cleveland Clinic, Cleveland, OH

    *Purpose: Decay-accelerating factor (DAF, CD55) is a cell surface expressed, glycophosphatidylinositol-(GPI)-anchored, complement regulator. Previous studies showed that during cognate T cell/antigen presenting cell (APC) interactions…
  • 2019 American Transplant Congress

    Lymphotoxin Signaling Regulates T Cell Lymphatic Trafficking

    W. Piao1, L. Li2, V. Saxena2, Y. Xiong2, M. WillsonShirkey2, C. Paluskievicz2, J. Bromberg3

    1Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, 2Surgery, U. Maryland, Baltimore, Baltimore, MD, 3Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Lymphotoxin (LT) α1β2 is crucial for lymphatic organ development and orchestration of immune responses. LTα1β2 is preferentially expressed by regulatory T cells (Treg) for…
  • 2019 American Transplant Congress

    mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells

    J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan

    Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
  • 2019 American Transplant Congress

    Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture

    P. Rajendran1, M. Cusick2, S. Dhingra3, B. Murthy1

    1Baylor College of Medicine, Houston, TX, 2Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, 3Pathology, Baylor College of Medicine, Houston, TX

    *Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…
  • 2019 American Transplant Congress

    Cellular And Molecular Characteristics Of Intra-graft Lymphoid Aggregates In Chronic Lung Allograft Dysfunction

    E. Miyamoto1, S. Juvet1, D. Hwang2, S. Keshavjee1, T. Martinu1

    1Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada, 2Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    *Purpose: Lymphoid aggregates (LAs) have been identified within lung allografts post lung transplant (LTx). However, it remains controversial whether they represent benign lymphoid tissue or…
  • 2019 American Transplant Congress

    Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation

    R. A. Sosa1, A. Q. Terry1, J. Nevarez-Mejia1, M. Rossetti1, B. V. Naini1, V. M. Groysberg1, F. M. Kaldas2, R. W. Busuttil2, D. W. Gjertson1, J. W. Kupiec-Weglinski2, E. F. Reed1

    1Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…
  • 2018 American Transplant Congress

    Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival

    G. Raimondi,1 P. Majumder,2 V. Ivanova,1 X. Calderon-Colon,3 A. Mirdad,1 M. Iglesias Lozano,1 W. Lee,1 G. Brandacher,1 J. Schneider,2 J. Patrone.3

    1Johns Hopkins School of Medicine, Baltimore; 2National Cancer Institute, Frederick; 3Johns Hopkins Applied Physics Laboratory, Laurel.

    Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…
  • 2018 American Transplant Congress

    Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands

    A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.

    Transplant Surgery, University of Wisconsin, Madison, WI.

    The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…
  • 2018 American Transplant Congress

    TLR-Activated Bregs Promote Islet Allograft Tolerance in an IL-10-Independent and TGF-β-Dependent Manner

    L. Kojima, K. Lee, K. Deng, H. Tector, C. Dai, S. Kimura, C. Rickert, H. Yeh, J. Markmann.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    Background: We previously demonstrated the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. Recently, we produced TLR-activated B cells in vitro that…
  • 2018 American Transplant Congress

    Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human

    K. Nakamura,1 S. Kageyama,1 M. Kujawski,2 T. Ito,1 A. Aziz,1 D. Oncel,1 B. Ke,1 R. Sossa,3 E. Reed,3 F. Kaldas,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, UCLA, Los Angeles, CA; 2Molecular Immunology, City of Hope, Duarte, CA; 3Pathology, UCLA, Los Angeles, CA.

    We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…
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