ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocyte activation"

  • 2022 American Transplant Congress

    Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation

    E. Bardhi1, K. Archer2, D. Maluf1, J. McDaniels1, T. Rousselle1, E. Akalin3, T. Mueller4, V. Mas1

    1University of Maryland, Baltimore, MD, 2Ohio State University, Columbus, OH, 3Montefiore Medical Center, Bronx, NY, 4University Hospital Zürich, Zürich, Switzerland

    *Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…
  • 2021 American Transplant Congress

    T Cell Repertoire Diversity in HCV-Associated Hepatocellular Carcinoma Patients Waitlisted for Liver Transplantation and Receiving Liver-Directed Therapy

    K. Nunez, T. Sandow, A. Cohen, P. Thevenot

    Ochsner Health, New Orleans, LA

    *Purpose: T cell receptor (TCR) sequencing in hepatocellular carcinoma (HCC) patients revealed a diverse TCR repertoire in hepatitis B-associated HCC-infiltrating T cells. In this study,…
  • 2021 American Transplant Congress

    Detection of SARS-CoV-2 Specific Functional T Cells Using a Seven Color Flow Cytometry Assay

    L. Flebbe-Rehwaldt, J. Hayden, K. Mickey, S. Manley, S. Kleiboeker

    Eurofins-Viracor, Lees Summit, MO

    *Purpose: The need to evaluate SARS-CoV-2 immune responses is an important clinical research focus. Detecting neutralizing antibodies is one measure of immune response, but the…
  • 2021 American Transplant Congress

    Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection

    J. Y. Choi1, H. Nakagawa2, Z. Solhjou1, K. Yatim1, H. Zhang3, P. Patel3, M. Tawfeek Mohammed3, L. Riella4, H. Kim2, H. Cantor2, J. Azzi1

    1Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 2Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
  • 2021 American Transplant Congress

    P2X7 Receptor Activity Mediates Th17-Specific Self- and Alloreactivity in Non-Human Primates

    C. Little, J. Sullivan, W. Burlingham, D. Kaufman

    Department of Surgery, University of Wisconsin, Madison, WI

    *Purpose: The broadly expressed ATP-binding purinergic receptor, P2X7 (P2X7R) is involved in the Th17 mediated cellular immune response to allo- and select self-antigens (Collagen type…
  • 2020 American Transplant Congress

    Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver

    K. Carlson1, F. Najmabadi1, J. Pavan-Guimaraes1, W. J. Burlingham1, C. M. Capitini2, D. P. Al-Adra1

    1Surgery, University of Wisconsin, Madison, WI, 2Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI

    *Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
  • 2020 American Transplant Congress

    Clinical Implication of Tertially Lymphoid Tissue in the Renal Graft

    M. Saito1, Y. Lee2, Y. Sato2, S. Narita1, S. Satoh1, M. Yanagita2, T. Habuchi1

    1Urology, Akita University Hospital, Akita, Japan, 2Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan

    *Purpose: Tertialy lymphoid organs (TLTs) are defined as inducible lymphoid tissues that arise in non-lymphoid organs, and chronic sustained inflammation is one of the most…
  • 2020 American Transplant Congress

    Influence of Microbial Communities on Transplantation

    K. Janek1, J. Fechner1, K. Krautkramer2, S. Sudakaran3, J. Denu4, J. Handelsman3, F. Rey5, E. Vivas5, J. Mezrich1

    1Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Wisconsin Institute for Discovery, Madison, WI, 4Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, 5Bacteriology, University of Wisconsin-Madison, Madison, WI

    *Purpose: A diverse microbiome is important in the generation, maintenance, and function of the immune system. Specific bacterial communities may have a relationship with organ…
  • 2020 American Transplant Congress

    Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation

    A. Dangi1, K. Glinton2, M. Sharma1, S. Yu1, M. DeBerge2, E. B. Thorp2, X. Luo1

    1Nephrology/Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL

    *Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…
  • 2019 American Transplant Congress

    Redox State of HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation

    R. A. Sosa1, A. Q. Terry1, J. Nevarez-Mejia1, M. Rossetti1, B. V. Naini1, V. M. Groysberg1, F. M. Kaldas2, R. W. Busuttil2, D. W. Gjertson1, J. W. Kupiec-Weglinski2, E. F. Reed1

    1Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, 2Surgery, UCLA, Los Angeles, CA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor of acute and chronic graft rejection in orthotopic liver transplantation (OLT) involving a complex interplay between…
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