Articles tagged "Lung"

2015 American Transplant Congress
Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments
L. Burdorf,¹ E. Rybak,¹ T. Zhang,¹ D. Harris,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ E. Sievert,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹
¹University of Maryland, Baltimore; ²Revivicor, Blacksburg.
Purpose: Prolonged life-supporting (LS) xenolung function has proven difficult to accomplish. Here we report results from 21 xLTXs in a rigorous, LS pig-to-baboon model, asking…
2015 American Transplant Congress
Effects of Mast Cell Stabilization on the Development of Aspiration-Induced Fibrosis in a Rat Model
E. Sapmaz, Z. Sun, J.-C. Chang, N. Sanders, S. Bell, M. Everett, Z. Holzknecht, W. Parker, R. Davis, S. Lin.
Surgery, Duke University Medical Center, Durham, NC.
Gastric fluid aspiration affects a great number of lung transplant recipients, both before and after the transplant, and can contribute significantly to morbidity and mortality.…
2015 American Transplant Congress
Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine
M. Madariaga, P. Spencer, S. Michel, G. La Muraglia II, M. O'Neil, E. Mannon, C. Leblang, I. Rosales, R. Colvin, D. Sachs, J. Allan, J. Madsen.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: We have previously shown that tolerance of heart allografts across a full MHC barrier can be induced in miniature swine after a 12-day course…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Does Pulmonary Rehabilitation Impact Frailty?
C. Kennedy,¹ P. Novotny,² N. LeBrasseur,³ R. Wise,⁴ F. Sciurba,⁵ R. Benzo.¹
¹Pulmonary and Critical Care, Mayo Clinic, Rochester, MN; ²Health Sciences Research-Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN; ³Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; ⁴Pulmonary and Critical Care, Johns Hopkins, Baltimore, MD; ⁵Pulmonary, Allergy and Critical Care, University of Pittsburgh, Pittsburgh, PA.
Purpose: Frailty is an emerging risk factor for morbidity and mortality in advanced lung disease and lung transplantation. Interventions to reduce frailty in this population…
2015 American Transplant Congress
Activation and Sequestration of Platelets During Xenogeneic GalTKO.hCD46 Pig Lung Perfusion Is Primarily Mediated By GPIb, GPIIb/IIIa, and VWF
L. Burdorf,¹ A. Riner,¹ A. Shah,¹ E. Schwartz,¹ K. Quinn,¹ E. Kang,¹ E. Sievert,¹ E. Rybak,¹ D. Harris,¹ T. Zhang,¹ D. Parsell,¹ X. Cheng,¹ G. Braileanu,¹ S. De Meyer,² I. Salles,² H. Deckmyn,² C. Phelps,³ D. Ayares,³ R. Pierson III,¹ A. Azimzadeh.¹
¹Surgery, University of Maryland, Baltimore, MD; ²Laboratory for Thrombosis Research, IRF-Ls, Kulak KU Leuven, Leuven, Belgium; ³Revivicor, Inc., Blacksburg, VA.
Background: Xenogeneic pig lung perfusion with human blood leads to the initiation of rejection mechanisms that are associated with the immediate sequestration of circulating platelets.…