Articles tagged "Lung preservation"

2019 American Transplant Congress
Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation
D. P. Allen¹, Z. Tu¹, C. Wallace¹, C. Li¹, J. Kilkenny¹, K. J. Patel¹, D. Nord², S. N. Nadig¹, C. Atkinson²
¹Surgery, Medical University of South Carolina, CHARLESTON, SC, ²Microbiology & Immunology, Medical University of South Carolina, CHARLESTON, SC
*Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…
2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Department of Surgery (Cardiac), University of Alberta, Edmonton, Canada.
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…
2018 American Transplant Congress
Ischemia Reperfusion Injury Significantly Differs between Lung vs. Heart Transplantation with Respect to Lead Cytokines and Correlation to Clinical Outcome
B. Wiegmann,¹ N. Ledwoch,² J. ISke,² C. Neudörfl,² I. Tudorache,¹ C. Kühn,¹ T. Kaufeld,¹ F. Ius,¹ S. Rojas,¹ M. Avsar,¹ A. Haverich,¹ G. Warnwcke,¹ C. Falk.¹
¹Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesIschemia reperfusion injury (IRI) is known to impair early graft function after lung (LTx) or heart (HTx) transplantation. We have previously characterized IRI in lungs…
2018 American Transplant Congress
Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates
B. Wiegmann,¹ R. BellmasSanz,² C. Neudörfl,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke,¹ C. Falk.²
¹Department of Cardiothoracic, Transplantation, Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
PurposeThe INSPIRE trial revealed significant reduction of PGD grade 3, i.e. less ischemia reperfusion injury (IRI) using the Organ Care System (OCS) compared to controls…
2018 American Transplant Congress
CXCR4 Inhibition Improves Donor Leukocyte Depletion during Ex Vivo Lung Perfusion
R. Davis, Q. Gao, J. Yerxa, M. Daneshmand, J. Haney, J. Klapper, M. Hartwig, A. Barbas.
Surgery, Duke University, Durham, NC.
Background: Ex vivo lung perfusion (EVLP) has emerged as a modern preservation technique, developed to evaluate candidate donor lungs in a normothermic and metabolically active…
2017 American Transplant Congress
Lung Preservation Solution Exposure at Cardiac Procurement Is Associated Increased Incidence of Coronary Arterial Vasculopathy.
H. Copeland,¹ V. Garcia,² A. Sima,² D. Baran,³ A. Mankind,⁴ G. Katlaps,¹ N. Lewis,⁴ B. Dharmaj,¹ J. Copeland.⁵
¹Cardiothoracic Surgery, McGuire VA Medical Center, Richmond, VA; ²Biostatistics, Virginia Commonwealth University, Richmond, VA; ³Cardiology, Beth Israel Medical Center Barnabas Health, Newark, NJ; ⁴Cardiology, McGuire VA Medical Center, Richmond, VA; ⁵Surgery, Division of Cardiothoracic Surgery, University of Arizona, Tucson, AZ
Purpose: To evaluate cardiac recipient survival and incidence of coronary artery vasculopathy (CAV) in recipient hearts that have been exposed to lung preservation solution, Perfadex.Methods:…
2017 American Transplant Congress
Preservation Solution Affects the Immunological Milieu in Lung Transplantation and Alters the Inflammatory Balance.
R. Bellmàs Sanz,¹ M. Seyda,¹ B. Wiegmann,² C. Neudoerfl,¹ A. Haverich,^2,3 C. Falk,^1,4 G. Warnecke.^2,3
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ³German Center for Lung Research (DZL), Hannover, Germany; ⁴German Center for Infection Research (DZIF), Hannover, Germany
Background: The pro-/ anti-inflammatory balance in lung transplantation is shaped by the pulmonary immune compartments, i.e. the T and NK cell repertoire. At present, it…
2016 American Transplant Congress
Rapamycin Encapsulated Nanoparticles as Pre-Treatment in Lung Transplantation.
G. Bazzle,¹ S. Dixit,² K. Patel,³ A.-M. Broome,² S. Nadig,^1,3 C. Atkinson.^1,3
¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Department of Radiology, Medical University of South Carolina, Charleston, SC; ³Department of Surgery, Medical University of South Carolina, Charleston, SC.
Introduction: While short-term lung transplant outcomes have improved over the years, long-term survival rates remain stagnant. Many injuries occur to the donor organ before transplantation,…
2015 American Transplant Congress
The Preservation Technique Modulates the Immunological Milieu in Lung Transplantation and Affects the Pro-/ Anti-Inflammatory Balance
M. Seyda,¹ B. Wiegmann,³ B. Mueller,² C. Neudoerfl,¹ A. Akhdar,¹ K. Daemen,¹ A. Haverich,^3,4 G. Warnecke,^3,4 C. Falk.^3,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany; ⁴German Center for Lung Research, Gießen, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
Little is known regarding the influence of different preservation techniques (i.e. cold static storage with Perfadex® or Celsior® solution) on the immunological milieu, especially lung-resident…
2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
B. Wiegmann,¹ C. Falk,² M. Seyda,² C. Neudörfl,² A. Akhdar,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke.¹
¹Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…