ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2015 American Transplant Congress

    Efficacy of Sofosbuvir Based Therapy for Recurrent Hepatitis C After Liver Transplantation

    A. Weick,1 K. George,1 S.-M. Jafri,2 D. Moonka.2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI; 2Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI.

    Purpose: Evaluate outcomes of sofosbuvir-based hepatitis C therapy in liver transplant patients in a single center clinical setting, including interferon-free regimens.Methods: All patients with history…
  • 2015 American Transplant Congress

    Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway

    J. Zhang,1 X. Liu,2 D. Li,1 H. Dai,1 J. Zhang,1 T. Lu,1 Q. Xia.1

    1Liver Transplantation Center, Renji Hospital, Shanghai, China; 2Cardiovascular, Shanghai First People/s Hospital, Shanghai, China.

    Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…
  • 2015 American Transplant Congress

    Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells

    R. Bascom, K. Tao, S. Tollenaar, L. West.

    University of Alberta, Edmonton, Canada.

    Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…
  • 2015 American Transplant Congress

    Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation

    S. Yue,1 X. Zhou,2 M. Zhou,1 Y. Zhai,1 R. Busuttil,1 Q. Ying,2 J. Kupiec-Weglinski,1 B. Ke.1

    1Dumont-UCLA Transplant Center, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Dept. of Stem Cell Biology & Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

    Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation

    N. Ishida, K. Ishiyama, F. Hirata, Y. Saeki, Y. Tanaka, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…
  • 2015 American Transplant Congress

    Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex

    Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.

    Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

    Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
  • 2015 American Transplant Congress

    Bioengineering Liver Allografts through Organ Scaffold Recellularization

    J. Woodall, J. Langford, C. Klassen, J. Harrison, D. Parsell, U. Dhru, R. Barth, J. LaMattina.

    University of Maryland School of Medicine, Baltimore.

    Bioengineering livers using organ scaffolds offers an approach to increasing allograft availability for end stage liver disease. Recellularized liver scaffolds will require multiple differentiated cell…
  • 2015 American Transplant Congress

    CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment

    R. Hotta,1 M. Ohira,2 T. Matsuura,1 I. Muraoka,1 P. Tryphonopoulos,1 J. Fan,1 A. Tekin,1 H. Ohdan,2 A. Tzakis,3 R. Vianna,1 S. Nishida.1

    1University of Miami, Miami, FL; 2Hiroshima University, Hiroshima, Japan; 3Cleveland Clinic Florida, Weston, FL.

    Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…
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