2015 American Transplant Congress
Hepatic Stellate Cells Directly Inhibit B Cells Via PD-L1
Hepatic stellate cells (HSCs) account for one third of the nonparenchymal cells in the liver, which are considered to be critical in maintaining the immunoprivileged…2015 American Transplant Congress
The Donor Risk Index Does Not Accurately Classify Patients With or Without Graft Failure
In liver transplantation assessing risk of donor is paramount to graft survival. The donor risk index (DRI) was introduced as a predictor of graft failure…2015 American Transplant Congress
Socioeconomic Status of Local Vs Exported Liver Recipients and Their Donors
1Massachusetts General Hospital, Boston, MA; 2Mayo Clinic, Rochester, MN.
INTRODUCTION: Broader sharing has been proposed as a solution to decrease geographic disparities in liver transplantation, with the hope that this will also neutralize the…2015 American Transplant Congress
Liver Transplantation in Children Using Organ Donation After Circulatory Death– An Analysis of the National Registry
Liver Transplant and Hepatobiliary, Cleveland, Cleveland, OH.
The waiting list mortality rate for children is higher than for adults owing to scarce availability of size-appropriate grafts for liver transplantation(OLT). There is a…2015 American Transplant Congress
MELD/PELD 35+ Candidates Benefit from Regional Sharing
Background: Based on a proposal from the Liver and Intestinal Organ Transplantation Committee, the OPTN implemented regional sharing for MELD/PELD 35+ candidates on June 18,…2015 American Transplant Congress
Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury
Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
Liver ischemia/reperfusion (I/R) injury is a clinically important phenomenon encountered during transplantation that contributes to initial graft function and subsequent allograft rejection. Formation of neutrophil…2015 American Transplant Congress
Organ Procurement Organization Level Changes in Liver Utilization After Share-35
Dept of Surgery, Johns Hopkins, Baltimore, MD.
The OPTN implemented Share-35 in June 2013 to increase regional sharing. Organ Procurement Organization (OPO)-level changes in utilization subsequent to Share-35 have not previously been…2015 American Transplant Congress
The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice
Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…2015 American Transplant Congress
Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury
Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…2015 American Transplant Congress
TGR5 Regulates Innate Immune Responses in Mouse Liver Ischemia-Reperfusion Injury Through NRF2/HO-1 Signaling Pathway
The G-Protein-Coupled Bile Acid Receptor (TGR5), also called Gpbar1 or GPBA, is a G-protein coupled plasma membrane receptor for Bile acids (BAs) which is expressed…
American Transplant Congress abstracts