2015 American Transplant Congress
Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury
Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…2015 American Transplant Congress
TGR5 Regulates Innate Immune Responses in Mouse Liver Ischemia-Reperfusion Injury Through NRF2/HO-1 Signaling Pathway
The G-Protein-Coupled Bile Acid Receptor (TGR5), also called Gpbar1 or GPBA, is a G-protein coupled plasma membrane receptor for Bile acids (BAs) which is expressed…2015 American Transplant Congress
Efficacy of Sofosbuvir Based Therapy for Recurrent Hepatitis C After Liver Transplantation
Purpose: Evaluate outcomes of sofosbuvir-based hepatitis C therapy in liver transplant patients in a single center clinical setting, including interferon-free regimens.Methods: All patients with history…2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…2015 American Transplant Congress
Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells
University of Alberta, Edmonton, Canada.
Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…2015 American Transplant Congress
Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…2015 American Transplant Congress
Bioengineering Liver Allografts through Organ Scaffold Recellularization
University of Maryland School of Medicine, Baltimore.
Bioengineering livers using organ scaffolds offers an approach to increasing allograft availability for end stage liver disease. Recellularized liver scaffolds will require multiple differentiated cell…2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…
American Transplant Congress abstracts