ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2015 American Transplant Congress

    Organ Procurement Organization Level Changes in Liver Utilization After Share-35

    E. Chow, A. Massie, X. Luo, A. Muzaale, D. Segev.

    Dept of Surgery, Johns Hopkins, Baltimore, MD.

    The OPTN implemented Share-35 in June 2013 to increase regional sharing. Organ Procurement Organization (OPO)-level changes in utilization subsequent to Share-35 have not previously been…
  • 2015 American Transplant Congress

    The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice

    T. Lu,1 D. Li,1 J. Zhang,1 M. Zhang,1 X. Cui,1 H. Dai,1 X. Liu,2 Q. Xia.1

    1Liver Surgery and Liver Transplantation Center, Renji Hospital, Shanghai, China; 2Cardiovascular, Shanghai First People's Hospital, Shanghai, China.

    Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…
  • 2015 American Transplant Congress

    Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury

    H. Zhou,1,2 J. Zhu,1,3 S. Yue,1 M. Zhang,3 R. Busuttil,1 Q. Xia,3 J. Kupiec-Weglinski,1 Y. Zhai.1

    1The Dumont-UCLA Transplant Center, UCLA, Los Angeles; 2Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; 3Liver Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

    Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…
  • 2015 American Transplant Congress

    TGR5 Regulates Innate Immune Responses in Mouse Liver Ischemia-Reperfusion Injury Through NRF2/HO-1 Signaling Pathway

    J. Rao, B. Hao, X. Wang, F. Zhang, L. Lu.

    Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    The G-Protein-Coupled Bile Acid Receptor (TGR5), also called Gpbar1 or GPBA, is a G-protein coupled plasma membrane receptor for Bile acids (BAs) which is expressed…
  • 2015 American Transplant Congress

    Efficacy of Sofosbuvir Based Therapy for Recurrent Hepatitis C After Liver Transplantation

    A. Weick,1 K. George,1 S.-M. Jafri,2 D. Moonka.2

    1Internal Medicine, Henry Ford Hospital, Detroit, MI; 2Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI.

    Purpose: Evaluate outcomes of sofosbuvir-based hepatitis C therapy in liver transplant patients in a single center clinical setting, including interferon-free regimens.Methods: All patients with history…
  • 2015 American Transplant Congress

    Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway

    J. Zhang,1 X. Liu,2 D. Li,1 H. Dai,1 J. Zhang,1 T. Lu,1 Q. Xia.1

    1Liver Transplantation Center, Renji Hospital, Shanghai, China; 2Cardiovascular, Shanghai First People/s Hospital, Shanghai, China.

    Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…
  • 2015 American Transplant Congress

    Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells

    R. Bascom, K. Tao, S. Tollenaar, L. West.

    University of Alberta, Edmonton, Canada.

    Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…
  • 2015 American Transplant Congress

    Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation

    S. Yue,1 X. Zhou,2 M. Zhou,1 Y. Zhai,1 R. Busuttil,1 Q. Ying,2 J. Kupiec-Weglinski,1 B. Ke.1

    1Dumont-UCLA Transplant Center, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Dept. of Stem Cell Biology & Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

    Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation

    N. Ishida, K. Ishiyama, F. Hirata, Y. Saeki, Y. Tanaka, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…
  • 2015 American Transplant Congress

    Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex

    Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.

    Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

    Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
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