Articles tagged "Liver"

2022 American Transplant Congress
Team Decision-Making in Liver Transplant Evaluation: A Multi-Center Ethnographic Observation Study
C. N. Sidoti, H. C. Sung, D. L. Segev, M. L. Levan, T. S. Purnell, A. T. Strauss
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Transplant providers are tasked with making ethically complex and high-stakes decisions of determining a patient’s candidacy for liver transplantation within a multi-disciplinary team. We…
2022 American Transplant Congress
Ex Vivo Liver Resection and Autotransplantation – Should It Be Used More Frequently?
J. Weiner¹, A. Griesemer¹, A. Hemming², D. Levi³, T. Beduschi⁴, R. Matsumoto¹, A. Mathur¹, J. Emond¹, T. Kato¹
¹Columbia University Irving Medical Center, New York, NY, ²University of Iowa, Iowa City, IA, ³Atrium Health, Charlotte, NC, ⁴University of Florida, Gainesville, FL
*Purpose: Ex vivo liver resection expands the limits of resectability for advanced liver tumors but remains underutilized due to concerns about technical complexity and vascular…
2022 American Transplant Congress
Designing Continuous Distribution for Liver Allocation
M. Mankowski¹, N. Wood², D. Segev³, S. Gentry²
¹Erasmus University, Rotterdam, Netherlands, ²US Naval Academy, Annapolis, MD, ³Johns Hopkins University, Baltimore, MD
*Purpose: The continuous distribution framework is required for all future organ allocation policies. Continuous distribution changes the allocation paradigm, prioritizing candidates according to a composite…
2022 American Transplant Congress
Portal Vein Thrombosis and DCD Liver Transplantation: Dangerous Combination or Clinical Opportunity?
E. Calderon¹, Y. Chang², P. Lu¹, A. M. Durant³, D. Derakshani⁴, M. L. Anderson⁴, E. R. Luque Villa², C. Jadlowiec², K. Reddy², A. Moss², A. K. Mathur²
¹General Surgery, Mayo Clinic, Phoenix, AZ, ²Mayo Clinic, Phoenix, AZ, ³Urology, Mayo Clinic, Phoenix, AZ, ⁴Mayo Clinic Alix School of Medicine, Phoenix, AZ
*Purpose: Individually, recipient portal vein thrombosis (PVT) and donation after circulatory death (DCD) allografts are associated with a higher risk of poor deceased donor liver…
2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
O. C. Rodriguez¹, J. R. Liggett², J. Kang², K. Loh², Y. Lee¹, N. Sang¹, B. He¹, Y. Cui², K. Oza², D. Kwon³, B. Kallakury³, T. Fishbein², W. Cui², K. Khan², C. Albanese¹, A. Kroemer²
¹Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Pathology, MedStar Georgetown University Hospital, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Y. Park¹, D. Thadasina¹, K. Isidan¹, K. J. Lopez¹, A. Cross-Najafi¹, P. Li¹, H. Francis², G. Alpini², W. Zhang¹, B. Ekser¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN, ²Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
J. Foutz¹, S. Noreen¹, M. Cafarella¹, A. Wilk¹, J. Trotter², S. Biggins³, J. Pomposelli⁴
¹United Network for Organ Sharing, Richmond, VA, ²Baylor University Medical Center, Dallas, TX, ³University of Washington, Seattle, WA, ⁴University of Colorado, Aurora, CO
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…
2022 American Transplant Congress
Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver
C. S. Hwang¹, C. Shi², M. Patel¹, J. Shah¹, L. DeGregorio¹, S. Hanish¹, Y. Kadakia³, U. Chaudhary³, E. Okoro², S. Cheruku², P. Lahsaei², P. Vagefi¹, M. MacConmara⁴
¹Surgery, University of Texas Southwestern Medical Center, Dallas, TX, ²Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, ³University of Texas Southwestern Medical Center, Dallas, TX, ⁴TransMedics, Andover, MA
*Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
2022 American Transplant Congress
Physicians Are Perfectionists and Patients Are Pragmatic? Comparing Physician and Patient Definitions of Success in Liver Transplantation
I. Woelfel¹, D. Faulkner¹, W. Kellett¹, K. Washburn², A. Schenk¹
¹Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: The purpose of this study was to compare and contrast patient and physician perceptions of success one year after liver transplantation.*Methods: This was a…
2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, J. Liggett, K. Oza, Y. Cui, K. Loh, D. Kwon, B. Kallakury, T. Fishbein, W. Cui, K. Kahn, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…