2018 American Transplant Congress
Liver Allocation: One OPO's Experience with Expedited versus Non-Expedited Placement
LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK.
Background: One organ procurement organization (OPO) sought to study expedited versus non-expedited livers recovered/transplanted after local/regional centers declined. The OPO sought to determine relative recipient…2018 American Transplant Congress
Effects of Preformed Antibody on Survival Following Pig-to-Primate Liver Xenotransplantation
Transplant Surgery, Massachusetts General Hospital, Boston, MA.
Objectives:Xenotransplantation represents the best near-term solution to address the current organ shortage. We have developed a pre-clinical model of pig-to-primate liver xenotransplantation (LXT), and now…2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…2018 American Transplant Congress
MELD Based Allocation Deteriorates Patient Survival without Improving Waiting List Mortality in a Low Donor Area
The MELD-based allocation system has been implemented in Germany in 2006 in order to decrease waiting list mortality in patients with end stage liver disease.…2018 American Transplant Congress
Assessment of Bile Production and Quality during Normothermic Ex Vivo Liver Perfusion to Predict Biliary Injury
Background. Liver transplantation (LT) with donation after circulatory death (DCD)-grafts is associated with higher risk for biliary strictures. We evaluated bile production and quality during…2018 American Transplant Congress
DAP12 and Its Triggering Co-Receptor TREM2 Play Key Roles in Regulation of Mouse and Human Liver DC Function and Control of Liver Ischemia-Reperfusion Injury
Background: Liver interstitial dendritic cells (DCs) have been implicated in the control of liver ischemia/reperfusion injury (IRI) and in the induction of liver transplant tolerance.…2018 American Transplant Congress
Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles.
Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…2018 American Transplant Congress
Umbilical Cords-Derived Mesenchymal Stem Cells Ameliorates Hepatic Ischemia-Reperfusion Injury via Activating the AMPK-mTOR/ULK1 Signaling Pathway Enhanced Autophagy
UC-MSCs induction of anti-apoptosis has been indicated to play protective roles in liver ischemia-reperfusion (I/R) model. However, the exact molecular mechanisms of UC-MSCs in hepatic…2018 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury
Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…2018 American Transplant Congress
hEPCR.hTBM.hCD47.HO-1 Contributes to Increased Survival, Reduced Platelet Sequestration, and Modulation of Coagulation Activation in GalTKO.hCD46 Porcine Livers Perfused with Human Blood
1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc., Baltimore, MD.
IntroductionPlatelet sequestration and inappropriate coagulation cascade activation are associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate a cassette of additional genetic…
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