Articles tagged "Liver"

2019 American Transplant Congress
Natural Course Of Tacrolimus Intra-patient Variability In Liver Transplant Recipients
N. Wilson, S. Tremblay, N. S. Ejaz, K. Zheng, J. Garrett, S. A. Shah, R. R. Alloway, T. E. Kaiser
University of Cincinnati, Cincinnati, OH
*Purpose: The evolution of tacrolimus (TAC) intra-patient variability (IPV) post liver transplant (LT) remains to be characterized. Identification of factors associated with high TAC-IPV may…
2019 American Transplant Congress
Sustained Biologic Response To Neoadjuvant Therapy Predicts Excellent Liver Transplant Outcomes For Locally Advanced Intrahepatic Cholangiocarcinoma
K. E. Lunsford¹, M. Javle², K. Heyne³, R. A. Ali², C. M. Mobley¹, A. Saharia¹, D. W. Victor¹, M. J. Hobeika¹, A. Kasab², R. S. McFadden¹, T. A. Aloia², X. C. Li¹, H. P. Monsour¹, A. O. Gaber¹, A. O. Gaber¹, J. Vauthey², R. M. Ghobrial¹
¹J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX, ²The University of Texas MD Anderson Cancer Center, Houston, TX, ³Department of Oncology, Houston Methodist Hospital, Houston, TX
*Purpose: Intrahepatic cholangiocarcinoma (iCCA) is a contraindication for liver transplant (LT), but prior studies limited evaluation to incidental iCCA. We recently reported significant improvement in…
2019 American Transplant Congress
Liver Transplantation for Acute Liver Failure: A 16 Year Experience with 214 Patients in the Post-MELD Era
R. McMillan, T. Ito, A. Aziz, A. Amin, A. Murray, J. DiNorcia III, V. G. Agopian, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Liver transplantation (LT) remains the gold standard treatment for acute liver failure (ALF). Our center has previously reported outcomes in the pre-Model for End…
2019 American Transplant Congress
mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells
J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan
Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
2019 American Transplant Congress
Immunologic Outcomes In Recipients Of Orthotopic Liver Transplant Induced Only With Steroids
S. N. Merwat, A. T. Chatila, M. Bilal, R. Kulkarni, H. L. Stevenson, J. H. Fair, S. K. Merwat, T. Kozlowski, M. A. Mujtaba
The University of Texas Medical Branch, Galveston, TX
*Purpose: Liver allografts are resistant to antibody mediated rejection (AMR) in the presence of preformed alloantibodies. In most cases donor specific antibodies (DSAs) disappear a…
2019 American Transplant Congress
Spindle and Kinetochore Associated Complex Subunit 3 Promotes Tumor Growth by Regulating CDK2/p53 Phosphorylation in Hepatocellular Carcinoma
Y. Hou¹, Z. Wang², L. Wu³
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ³Organ transplant center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Spindle and kinetochore-related complex subunit 3 (SKA3) is a part of the spindle and kinetochore-related complexes, which are crucial for the proper timing of…
2019 American Transplant Congress
Evaluation of Liver Transplantation among Advanced Age Recipients in a Large Multicenter U.S. Cohort
A. Goel¹, A. Kwong², D. Devuni³, C. Wang², J. Boike⁴, J. Jo⁴, L. VanWagner⁴, M. Serper⁵, L. Jones⁵, R. Sharma⁶, E. Verna⁶, J. Shor³, M. German⁷, A. Hristov⁷, A. Lee⁷, E. Spengler⁷, A. Koteish⁸, G. Sehmbey⁹, A. Seetharam⁹, N. John¹, Y. Patel¹⁰, M. Kappus¹⁰, T. Couri¹¹, R. Salgia¹², Q. Nhu¹³, C. Frenette¹³, J. Lai²
¹Stanford University, Palo Alto, CA, ²University of California, San Francisco, CA, ³University of Massachusetts, Worcester, MA, ⁴Northwestern, Chicago, IL, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Columbia University, New York, NY, ⁷University of Wisconsin, Madison, WI, ⁸Florida Hospital, Orlando, FL, ⁹University of Arizona, Phoenix, AZ, ¹⁰Duke University, Durham, NC, ¹¹University of Chicago, Chicago, IL, ¹²Henry Ford Hospital, Detroid, MI, ¹³Scripps, San Diego, CA
*Purpose: The proportion of adults ≥70 years (y) listed for liver transplant (LT) in the U.S. is rising. Outcomes in this growing population are limited…
2019 American Transplant Congress
Interferon Sensitivity Promotes Recovery from Acetaminophen Induced Liver Injury
S. Datta, T. Hamilton, G. C. Sen
Inflammation and Immunity, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: The current study was undertaken to assess the role of inflammatory signaling during induction of and recovery from acetaminophen induced acute liver failure.*Methods: C57BL/6…
2019 American Transplant Congress
Access to Deceased Donor Liver Transplant for Candidates in Hawaii and Puerto Rico
A. M. Robinson¹, I. K. Kim², A. K. Mathur³, S. E. Rosas⁴
¹United Network for Organ Sharing, Richmond, VA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Mayo Clinic Arizona, Phoenix, AZ, ⁴Joslin Diabetes Center, Harvard Medical School, Boston, MA
*Purpose: Hawaii and Puerto Rico comprise their own donor service areas (DSAs), HIOP and PRLL respectively. The liver programs in these locations serve populations mostly…
2018 American Transplant Congress
Factors Associated with the Development of Chronic Kidney Disease after Liver Transplantation
M. Kalisvaart, A. Schlegel, P. Trivedi, K. Roberts, D. Mirza, T. Perera, J. Isaac, J. Ferguson, P. Muiesan.
Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom.
BackgroundRenal dysfunction is a common complication after liver transplantation. The increased use of DCD livers has been associated with postoperative acute kidney injury (AKI). However,…