Articles tagged "Liver"

2020 American Transplant Congress
Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model
W. Zhang¹, A. Isidan¹, A. M. Chen¹, L. J. Smith², H. L. Francis³, G. Alpini³, E. Gramelspacher¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…
2020 American Transplant Congress
A Single-Center Characterization of the Living Liver Donor Evaluation Process
L. R. Herbst, A. D. Love, M. Krach, Y. Yu, L. Kurman, A. Gurakar, M. Hammami, A. M. Cameron, J. Garonzik Wang
Department of Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: We have previously characterized the living kidney donor evaluation and found that African American (AA) donors were less likely to progress through the process…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion/Injury in a Murine Model
A. Kobayashi¹, A. Wanchoo², J. Simonovich², S. Duarte¹, V. Boominathan¹, S. Shrestha¹, G. Hudalla², B. Keselowsky²
¹Surgery, University of Florida, Gainesville, FL, ²Biomedical Engineering, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor organs. However, despite its obvious…
2020 American Transplant Congress
Comparative Proteomics Analysis Identifies L-FABP as a Putative Biomarker of Graft Injury During Liver Transplantation Using the ITRAQ/MRM Approach
M. Chen, Y. Zhang, M. Han, W. Ju, Q. Zhao, Y. Chen, D. Wang, X. He
Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: In liver transplantation, much of factors have a pernicious influence on liver donor quality, such as hepatic steatosis, long term of donor hypotension, cardiac…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
A. Gillooly¹, C. Moore¹, J. Perry¹, I. Bruggenwirth², M. Thijssen², X. Wang¹, X. E¹, P. Mandrekar¹, T. Kowalik¹, R. Porte², H. Leuvenink², R. Abdi³, A. Bozorgzadeh¹, P. N. Martins¹
¹University of Massachusetts Medical School, Worcester, MA, ²University of Groningen, Groningen, Netherlands, ³Brigham and Women's Hospital, Boston, MA
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…
2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
W. S. Fagg¹, N. Liu¹, M. Shoja¹, I. Patrikeev², M. Motamedi², J. Fair¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
2019 American Transplant Congress
Outcomes Following Open Inguinal Hernia Repair in Liver Transplant versus Cirrhotic Patients
N. Siegel, A. Kernodle, S. DiBrito, T. Ishaque, D. Segev, J. Garonzik-Wang
Johns Hopkins, Baltimore, MD
*Purpose: Patients with cirrhosis are at an increased risk for post-operative complications after open inguinal hernia repair (OIHR). Conversely, liver transplant recipients (LTR) may have…