Articles tagged "Liver"

2020 American Transplant Congress
Community Affluence Impacts Patient Survival Post Liver Transplantation
D. Jorgensen, A. Humar, C. Hughes, M. Molinari, A. Ganoza, S. Ganesh, A. Duarte-Rojo, A. Tevar
Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: Liver transplantation is an effective treatment for patients with end stage liver disease with excellent patients and grafts long term outcomes. Many recipient disease…
2020 American Transplant Congress
Child-Turcotte-Pugh Class at Transplantation Predicts Mortality after Heart Transplantation Following Left Ventricular Assist Device Placement
E. Leven¹, A. T. Kurdi², S. Pinney¹, T. Schiano¹, J. Crismale¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, ²Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: The primary aim of this study is to assess whether Child-Turcotte-Pugh (CTP) class is associated with mortality in end-stage heart disease patients undergoing left…
2020 American Transplant Congress
Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model
W. Zhang¹, A. Isidan¹, A. M. Chen¹, L. J. Smith², H. L. Francis³, G. Alpini³, E. Gramelspacher¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…
2020 American Transplant Congress
Muscle-Liver Crosstalk via the Myokine MG53 Plays a Critical Role in Hepatocellular Repair
C. Akateh, J. Ko, B. F. Reader, J. Kim, Y. Lee, B. A. Whitson, J. Ma, S. M. Black
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Transplantation remains the only effective treatment for end-stage liver disease, but the number of organs deemed suitable for transplantation falls far short of the…
2020 American Transplant Congress
Plasma Microbiome Profiles of Liver Transplant Patients with Operational Tolerance
C. Kuscu¹, J. Pierre², I. Lies¹, C. Kuscu¹, A. Bajwa¹, A. Wolen¹, J. Eason¹, B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹James D. Eason Transplant Institute, Department of Surgery, UTHSC, Memphis, TN, ²Department of Pediatrics, UTHSC, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, UPMC, Pittsburgh, PA
*Purpose: Microbiome has emerged as a key modulator of organ homeostasis and immune system function with altered microbiota and microbiome - host interactions contributing to…
2020 American Transplant Congress
Relapse-Prone Unresectable Hepatoblastoma (HB) Requiring Liver Transplantation (LT) Are Immunogenic and May Be Sensitive to Immune Checkpoint Inhibitors
M. Ningappa¹, C. Ashokkumar¹, J. Garifallou², M. Gonzalez², H. Hakonarson², S. Ranganathan¹, B. W. Higgs¹, R. Sindhi¹
¹Pediatric Transplant, Pittsburgh, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Unresectable HB accounts for 8% of all pediatric LT. Post-LT relapse rates approach 20% indicating a need for more effective neoadjuvant chemotherapy.*Methods: To discover…
2020 American Transplant Congress
Mindfulness at Methodist – Stress Resiliency Strategies for Patients
E. Vivian¹, H. Oduor², P. Mantry³
¹Digestive Institute, Methodist Dallas Medical Center, Dallas, TX, ²Transplant Institute, Methodist Dallas Medical Center, Dallas, TX, ³The Liver Institute, Methodist Dallas Medical Center, Dallas, TX
*Purpose: Stress triggers changes in the brain that make people appear distracted and forgetful. Chronic stress damages DNA, causes excess inflammation in the body, impairs…
2020 American Transplant Congress
Comparative Proteomics Analysis Identifies L-FABP as a Putative Biomarker of Graft Injury During Liver Transplantation Using the ITRAQ/MRM Approach
M. Chen, Y. Zhang, M. Han, W. Ju, Q. Zhao, Y. Chen, D. Wang, X. He
Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: In liver transplantation, much of factors have a pernicious influence on liver donor quality, such as hepatic steatosis, long term of donor hypotension, cardiac…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…