Articles tagged "Liver"

2020 American Transplant Congress
Development of a Novel Multidrug Combination to Defat Steatotic Rat Liver via Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, G. Upadhya¹, J. Jia¹, C. Lee¹, J. Xing¹, L. Ye¹, S. Shim¹, Z. Zhang¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Surgery, Washington University, St. Louis, MO, ²Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies (Yarmush et al., Y defatting) have successfully reduced the…
2020 American Transplant Congress
Muscle-Liver Crosstalk via the Myokine MG53 Plays a Critical Role in Hepatocellular Repair
C. Akateh, J. Ko, B. F. Reader, J. Kim, Y. Lee, B. A. Whitson, J. Ma, S. M. Black
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Transplantation remains the only effective treatment for end-stage liver disease, but the number of organs deemed suitable for transplantation falls far short of the…
2020 American Transplant Congress
Plasma Microbiome Profiles of Liver Transplant Patients with Operational Tolerance
C. Kuscu¹, J. Pierre², I. Lies¹, C. Kuscu¹, A. Bajwa¹, A. Wolen¹, J. Eason¹, B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹James D. Eason Transplant Institute, Department of Surgery, UTHSC, Memphis, TN, ²Department of Pediatrics, UTHSC, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, UPMC, Pittsburgh, PA
*Purpose: Microbiome has emerged as a key modulator of organ homeostasis and immune system function with altered microbiota and microbiome - host interactions contributing to…
2020 American Transplant Congress
Relapse-Prone Unresectable Hepatoblastoma (HB) Requiring Liver Transplantation (LT) Are Immunogenic and May Be Sensitive to Immune Checkpoint Inhibitors
M. Ningappa¹, C. Ashokkumar¹, J. Garifallou², M. Gonzalez², H. Hakonarson², S. Ranganathan¹, B. W. Higgs¹, R. Sindhi¹
¹Pediatric Transplant, Pittsburgh, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Unresectable HB accounts for 8% of all pediatric LT. Post-LT relapse rates approach 20% indicating a need for more effective neoadjuvant chemotherapy.*Methods: To discover…
2020 American Transplant Congress
Mindfulness at Methodist – Stress Resiliency Strategies for Patients
E. Vivian¹, H. Oduor², P. Mantry³
¹Digestive Institute, Methodist Dallas Medical Center, Dallas, TX, ²Transplant Institute, Methodist Dallas Medical Center, Dallas, TX, ³The Liver Institute, Methodist Dallas Medical Center, Dallas, TX
*Purpose: Stress triggers changes in the brain that make people appear distracted and forgetful. Chronic stress damages DNA, causes excess inflammation in the body, impairs…
2020 American Transplant Congress
Child-Turcotte-Pugh Class at Transplantation Predicts Mortality after Heart Transplantation Following Left Ventricular Assist Device Placement
E. Leven¹, A. T. Kurdi², S. Pinney¹, T. Schiano¹, J. Crismale¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, ²Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: The primary aim of this study is to assess whether Child-Turcotte-Pugh (CTP) class is associated with mortality in end-stage heart disease patients undergoing left…
2020 American Transplant Congress
Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model
W. Zhang¹, A. Isidan¹, A. M. Chen¹, L. J. Smith², H. L. Francis³, G. Alpini³, E. Gramelspacher¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…
2020 American Transplant Congress
A Single-Center Characterization of the Living Liver Donor Evaluation Process
L. R. Herbst, A. D. Love, M. Krach, Y. Yu, L. Kurman, A. Gurakar, M. Hammami, A. M. Cameron, J. Garonzik Wang
Department of Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: We have previously characterized the living kidney donor evaluation and found that African American (AA) donors were less likely to progress through the process…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…