Articles tagged "Liver"

2020 American Transplant Congress
Rouleaux Formation in Human Livers During Normothermic Machine Perfusion
M. Harris¹, S. Raigani², C. Albert³, M. Reschke³, C. Carroll², J. T. Langford¹, C. Edwards⁴, D. Mulligan⁴, D. Haakinson¹, K. Uygun², H. Yeh², G. Tietjen¹
¹Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, ²Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Yale School of Engineering and Applied Science, New Haven, CT, ⁴Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT
*Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…
2020 American Transplant Congress
Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation
Y. Imaoka, M. Ohira, K. Sato, H. Ohdan
Hiroshima Uni., Hiroshima, Japan
*Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
2020 American Transplant Congress
Living Donor Gender Disparities Vary by Donor-Recipient Familial Relationship
Y. Chen¹, Y. Hung², C. de Crescenzo¹, C. Rickert¹, Y. Hsu³, H. Yeh¹, D. Chang¹
¹Department of Surgery, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Sinai Hospital of Baltimore, Baltimore, MA, ³Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, MA
*Purpose: Women are more likely to be living transplant donors and less likely to be recipients. It has been difficult to distinguish how much of…
2020 American Transplant Congress
Between-Center Variation in the Survival Benefit of Liver Transplant in the United States
A. Plana¹, S. Paul¹, A. Pillai¹, M. M. Churpek², E. Huang¹, R. Gibbons¹, W. H. Parker¹
¹University of Chicago, Chicago, IL, ²School of Medicine and Public Health, University of Wisconsin, Madison, WI
*Purpose: Survival benefit of liver transplantation is strongly correlated with Model for End Stage Liver Disease (MELD) score at transplant. Variability in organ supply across…
2020 American Transplant Congress
MY-ATLAS: A Novel Simulation Algorithm for Liver Transplant Allocation
C. G. Rickert¹, H. Zhao², Z. Leung², M. Akan³, J. F. Markmann¹, S. Tayur³, H. Yeh¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²City University of Hong Kong, Hong Kong, China, ³Tepper School of Business, Carnegie Mellon University, Pittsburgh, PA
*Purpose: Currently, the primary tool for modeling expected outcomes from changes in allocation policy is the SRTR-run Liver Simulated Allocation Model (LSAM), which is neither…
2020 American Transplant Congress
Tetramethylpyrazine Activated Pparγ in Resuscitating the Liver Graft Donatedafter Cardiac Death
F. Zhen, F. Lin, Z. Lihua, L. Wenjin, X. Yan, C. Yong, Y. Qifa
Zhongnan Hospital of Wuhan University, Wuhan, China
*Purpose: to identify whether Tetramethylpyrazine (TMP) pretreatment can protect DCD grafts preserved during cold storage or/and HMP and transplanted.The protective mechanisms of TMP were also…
2020 American Transplant Congress
Liver Transplantation with Grafts from Super Obese Donors with a BMI>50
P. Vargas¹, J. M. Cullen¹, P. Northup², J. Oberholzer¹, S. Pelletier¹, N. Goldaracena¹
¹Department of Surgery, Division of Transplantation, University of Virginia Health System, Charlottesville, VA, ²Department of Medicine-Gastroenterology, University of Virginia Health System, Charlottesville, VA
*Purpose: Organ shortage is aggravated by an obesity epidemic. There is limited data on liver transplant (LT) outcomes from liver grafts originating from super obese…
2020 American Transplant Congress
Tolerant Liver Transplant Patients Have Higher Level of Y RNA Fragments in the Circulation
C. Kuscu¹, A. Wolen¹, A. Bajwa¹, C. Kuscu¹, J. Eason², B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Tolerance post transplantation continue to be the ultimate goal in transplantation. Circulating small RNAs are one of the best candidates for biomarker studies. To…
2020 American Transplant Congress
Patient Reported Medication Nonadherence and Tolerability: Results of a Prospective Observational Study
D. Taber, N. Patel, K. Foster, F. Bartlett, C. Perez, H. Meadows, N. Pilch, A. Posadas, K. Soliman, V. Rao, M. Casey, V. Rohan, J. McGillicuddy, S. Nadig, D. Dubay
MUSC, Charleston, SC
*Purpose: Medication nonadherence (MNA) is a major contributor to late allograft loss in transplantation (txp). Immunosuppression therapy is highly effective at preventing rejection yet presents…
2020 American Transplant Congress
Pediatric National Liver Review Board: Impact on Children on the Waitlist
J. Foutz¹, S. Noreen¹, E. Hsu², E. Perito³, G. Mazariegos⁴
¹United Network for Organ Sharing, Richmond, VA, ²Seattle Children's Hospital, Seattle, WA, ³UCSF Benioff Children's Hospital, San Francisco, CA, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: On 5/14/19 changes were made to the exceptions review process for pediatric liver transplant candidates, with transition from 11 Regional Review Boards to one…