Articles tagged "Liver"

2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Outcomes of Robotic Living Donor Right Hepatectomy in Liver Transplant Recipients: A Systematic Review and Meta-analysis
E. Lincango-Naranjo¹, E. Garces-Delgado², P. Solis-Pazmino³, H. Alexander-Leon⁴, G. Restrepo-Rodas², R. Mancero-Montalvo², C. J. Ponce², R. Cadena-Semanate², R. Vargas-Cordova⁵, G. Herrera-Cevallos⁶, A. Villarreal-Juris⁷, S. Vallejo¹, C. Liu-Sanchez⁸, L. P. Prokop⁹, A. D. Guerron¹⁰, O. J. Ponce¹, D. Moris¹¹
¹Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, ²Universidad Internacional del Ecuador, Quito, Ecuador, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Universidad de las Americas, Quito, Ecuador, ⁵Hospital General San Francisco IESS, Quito, Ecuador, ⁶Hospital Metropolitano, Quito, Ecuador, ⁷Universidad Central del Ecuador, Quito, Ecuador, ⁸Universidad Peruana Cayetano Heredia, Lima, Peru, ⁹Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, ¹⁰Department of Surgery, Duke University, Durham, NC, ¹¹Department of surgery, Duke University, Durham, NC
*Purpose: Living donor adult-to-adult liver transplantation (LT) has emerged as a feasible alternative to deceased donors. Advances in hepatobiliary surgery have allowed the introduction of…
2021 American Transplant Congress
The Impact of Thromboelastography on Decreasing Blood Product Usage in Liver Transplantation
A. Mohamed¹, T. Kitajima¹, S. Angappan², K. Delvecchio¹, A. M. Elsabbagh¹, S. Yeddula¹, M. Shamaa¹, K. Collins¹, M. Rizzari¹, A. Yoshida¹, M. Abouljoud¹, J. El-Bashir², S. Nagai¹
¹Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Department of Anesthesiology, Henry Ford Hospital, Detroit, MI
*Purpose: Liver dysfunction results in derangement of hemostasis and thrombosis. Thromboelastography (TEG) has emerged as a tool to guide resuscitative efforts. However, its utilization and…
2021 American Transplant Congress
Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases: A Multicenter Experience
L. I. Ruffolo¹, K. Sasaki², K. Tomiyama¹, A. Nair¹, M. Orloff¹, B. Al-Judaibi³, M. Levstik³, M. Laryea³, K. Dokus¹, J. Errigo¹, A. Moro², C. Quintini², K. Hashimoto², M. Fujiki², K. Menon², C. Kwon², T. Diago Uso², R. Hernandez-Alejandro¹, F. Aucejo²
¹Surgery, University of Rochester Medical Center, Rochester, NY, ²Surgery, The Cleveland Clinic Foundation, Cleveland, OH, ³Transplant Hepatology, University of Rochester Medical Center, Rochester, NY
*Purpose: Colorectal cancer is the third leading cause of cancer related death, unfortunately 50% of patients will develop colorectal liver metastases (CRLM), and a minority…
2021 American Transplant Congress
Black Patients with Cirrhosis Have Longer Length of Stay and Higher Mortality When Hospitalized
A. Thomas¹, D. Simpson², D. P. Ladner², R. Berkowitz²
¹ACS Clinical Scholar, Chicago, IL, ²Transplant Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Black patients with cirrhosis have been shown to have higher liver-related mortality compared to White patients. However, little knowledge exists about racial differences related…
2021 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptor Tyrosine Kinases in Liver Ischemia/reperfusion Injury
J. Zhang¹, H. Zhang¹, M. Ni², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Liver Suyrgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2021 American Transplant Congress
Is Low Systemic Fibrinolytic Activity During the Anhepatic Phase Liver Transplant Surgery Associate with the Dreaded Post-Operative Complication of Hepatic Artery Thrombosis?
H. B. Moore¹, Y. Bababekov¹, J. Pomposelli¹, T. Ferrell¹, F. Azam¹, M. Adams², D. Yoeli¹, R. Choudhury¹, M. Wachs², E. Pomfret¹, T. Nydam¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital Colorado, Aurora, CO
*Purpose: Removal of the native liver during transplantation results in impaired clearance of clot degrading proteins and activation of fibrinolysis as appreciated by Starzl in…
2021 American Transplant Congress
Benign Pneumatosis Intestinalis with Pneumoperitoneum in the Immunocompromised Patient: Three Cases
A. Mohamed, K. Delvecchio, T. Kitajima, M. Rizzari, K. Collins, A. Yoshida, S. Nagai, J. Denny, M. Abouljoud
Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Isolated pneumatosis intestinalis after solid organ transplantation, as well as its surgical management in appropriate clinical context, is a well described entity. The management…