Articles tagged "Liver"

2021 American Transplant Congress
Degree of T Cell Infiltration Predicts Treatment Response in Pediatric Liver Late Acute Cellular Rejection
M. Rogers, G. Begum, Q. Sun, A. Peters
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Late acute cellular rejection (ACR) occurs >6mo post-liver transplant and is associated with chronic rejection and allograft loss. Currently, no diagnostic features predict ACR…
2021 American Transplant Congress
Spleen Tyrosine Kinase (syk): A Novel Regulator of Neutrophil Infiltration in Hepatic Iri
V. Boominathan, A. Kobayashi, S. Duarte, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia-reperfusion injury (IRI) plays a governing role in orthotopic liver transplantation, significantly impairing early graft function and increasing organ susceptibility to rejection. Neutrophil…
2021 American Transplant Congress
Effects of TIPS on Transplant Outcomes for HCC
C. L. Hanlon¹, D. Toy¹, Y. Liu¹, S. Zhou¹, K. Zhou², J. Kahn², L. Yuan²
¹Internal Medicine, University of Southern California, Los Angeles, CA, ²Internal Medicine - Department of Gastroenterology and Hepatology, University of Southern California, Los Angeles, CA
*Purpose: The purpose of this study is to examine effects of TIPS placement on response to locoregional therapy (LRT) and clinical outcomes after liver transplantation…
2021 American Transplant Congress
Combined Liver and Lung Transplantation with Extended Normothermic Liver Preservation Using Transmedics Organ Care System (OCS)^TM Liver: A Single Center Experience
J. Konel¹, M. Shamaa², O. Shamaa², A. Elsabbagh², T. Kitajima², T. Ivanics², K. Delvecchio², A. Mohamed², S. Yeddula², K. Collins², A. Yoshida², M. Abouljoud², S. Nagai², M. Rizzari²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Transplant Institute, Detroit, MI
*Purpose: Combined liver-lung transplantation (CLLT) is indicated in patients who cannot survive single-organ transplantation alone. Ex-situ normothermic machine perfusion (NMP) has been used to increase…
2021 American Transplant Congress
Change in Deceased Donor Demographics with Drug Intoxication Deaths: 2010 – 2019
D. Musgrove, D. Zaun, A. Israni, J. Snyder
SRTR, Minneapolis, MN
*Purpose: To understand the demographic change in deceased donor causes of death associated with drug intoxication, we explored trends over the 10-year period ending in…
2021 American Transplant Congress
An Immune-modulatory Strategy to Mitigate Hepatic Ischemia/reperfusion Injury in a Murine Model
A. Kobayashi, A. Wanchoo, S. Farhadi, J. Simonovich, S. Duarte, V. Boominathan, S. Shrestha, G. Hudalla, B. G. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2021 American Transplant Congress
Liver Transplantation Following Checkpoint Inhibitor Therapy – Timing is Everything
G. T. Schnickel¹, J. Parekh¹, Y. Kono², J. Berumen¹, V. Ajmeera², K. Mekeel¹
¹Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California San Diego, San Diego, CA, ²Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA
*Purpose: Use of checkpoint inhibitors (CPI) prior to liver transplantation has not been well studied and limited case reports describe a risk of early graft…
2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2021 American Transplant Congress
Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial
J. Markmann¹, M. Abouljoud², M. Ghobrial³, C. Bhati⁴, S. Pelletier⁵, J. Magliocca⁶, T. Pruett⁷, A. Lu⁸, M. Rizzari⁹, S. Ottmann¹⁰, T. Klair¹¹, C. Eymard¹², G. Roll¹³, G. Reyes¹⁴, S. Black¹⁵, S. Florman¹⁶, S. Mirani¹⁷, C. Marsh¹⁸, G. Schnickel¹⁹, M. Kinkhabwala²⁰, A. Demetris²¹, H. Yeh²², P. Vagefi²³, M. MacConmara²³
¹MGH, Boston, MA, ²Henry Ford, Detroit, MI, ³Houston Methodist, Houston, TX, ⁴Virginia Commonwealth, Richmond, VA, ⁵UVA, Charlottesville, VA, ⁶Emory, Atlanta, GA, ⁷U. Minnesota, Minneapolis, MN, ⁸Tampa General, Tampa, FL, ⁹Henry Ford, Detriot, MI, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹University of Texas HSC, San Antonio, TX, ¹²University of Tennessee HSC, Memphis, TN, ¹³UCSF, San Francisco, CA, ¹⁴U. Washington, Seattle, WA, ¹⁵Ohio State, Columbus, OH, ¹⁶Mt. Sinai, New York, NY, ¹⁷U. Nebraska, Omaha, NE, ¹⁸Scripps Clinic, San Diego, CA, ¹⁹U. San Diego, San Diego, CA, ²⁰Montefiore, New York, MA, ²¹UPMC, Pittsburgh, PA, ²²Massachusetts General Hospital, Boston, MA, ²³UT Southwestern, Dallas, TX
*Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
2021 American Transplant Congress
Nanodiamond-doxorubicin Complexes Improve Hepatic Ischemia/reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…