Articles tagged "Liver"

2021 American Transplant Congress
Liver Transplantation Following Checkpoint Inhibitor Therapy – Timing is Everything
G. T. Schnickel¹, J. Parekh¹, Y. Kono², J. Berumen¹, V. Ajmeera², K. Mekeel¹
¹Division of Transplant and Hepatobiliary Surgery, Department of Surgery, University of California San Diego, San Diego, CA, ²Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, CA
*Purpose: Use of checkpoint inhibitors (CPI) prior to liver transplantation has not been well studied and limited case reports describe a risk of early graft…
2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2021 American Transplant Congress
Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial
J. Markmann¹, M. Abouljoud², M. Ghobrial³, C. Bhati⁴, S. Pelletier⁵, J. Magliocca⁶, T. Pruett⁷, A. Lu⁸, M. Rizzari⁹, S. Ottmann¹⁰, T. Klair¹¹, C. Eymard¹², G. Roll¹³, G. Reyes¹⁴, S. Black¹⁵, S. Florman¹⁶, S. Mirani¹⁷, C. Marsh¹⁸, G. Schnickel¹⁹, M. Kinkhabwala²⁰, A. Demetris²¹, H. Yeh²², P. Vagefi²³, M. MacConmara²³
¹MGH, Boston, MA, ²Henry Ford, Detroit, MI, ³Houston Methodist, Houston, TX, ⁴Virginia Commonwealth, Richmond, VA, ⁵UVA, Charlottesville, VA, ⁶Emory, Atlanta, GA, ⁷U. Minnesota, Minneapolis, MN, ⁸Tampa General, Tampa, FL, ⁹Henry Ford, Detriot, MI, ¹⁰Johns Hopkins, Baltimore, MD, ¹¹University of Texas HSC, San Antonio, TX, ¹²University of Tennessee HSC, Memphis, TN, ¹³UCSF, San Francisco, CA, ¹⁴U. Washington, Seattle, WA, ¹⁵Ohio State, Columbus, OH, ¹⁶Mt. Sinai, New York, NY, ¹⁷U. Nebraska, Omaha, NE, ¹⁸Scripps Clinic, San Diego, CA, ¹⁹U. San Diego, San Diego, CA, ²⁰Montefiore, New York, MA, ²¹UPMC, Pittsburgh, PA, ²²Massachusetts General Hospital, Boston, MA, ²³UT Southwestern, Dallas, TX
*Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
2021 American Transplant Congress
Nanodiamond-doxorubicin Complexes Improve Hepatic Ischemia/reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…
2021 American Transplant Congress
Machine Learning Informs Utility-Based Non-Directed Living Liver Donor Allocation
K. Bambha¹, J. Perkins¹, M. Sturdevant¹, S. W. Biggins¹, R. Bakthavatsalam¹, P. Healey², A. Dick², J. Reyes¹
¹University of Washington, Seattle, WA, ²Seattle Children's, Seattle, WA
*Purpose: To maximize non-directed living liver donor graft utility, we developed analytic models predicting 10-year graft survival post liver transplant (LT).*Methods: We analyzed OPTN living…
2021 American Transplant Congress
Are Liver Transplant Center Websites Accessible to All?
C. E. Jacobson¹, R. Olmeda Barrientos², M. A. Anderson³, M. J. Englesbe³, S. A. Waits³, V. S. Valbuena³
¹University of Michigan Medical School, Ann Arbor, MI, ²University Of California – Riverside, School of Medicine, Riverside, CA, ³Department of Surgery, University of Michigan Health System, Ann Arbor, MI
*Purpose: Ensuring equitable access to transplant center information is an important step in combating health disparities in liver transplantation. This study aimed to assess liver…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Outcomes of Robotic Living Donor Right Hepatectomy in Liver Transplant Recipients: A Systematic Review and Meta-analysis
E. Lincango-Naranjo¹, E. Garces-Delgado², P. Solis-Pazmino³, H. Alexander-Leon⁴, G. Restrepo-Rodas², R. Mancero-Montalvo², C. J. Ponce², R. Cadena-Semanate², R. Vargas-Cordova⁵, G. Herrera-Cevallos⁶, A. Villarreal-Juris⁷, S. Vallejo¹, C. Liu-Sanchez⁸, L. P. Prokop⁹, A. D. Guerron¹⁰, O. J. Ponce¹, D. Moris¹¹
¹Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, ²Universidad Internacional del Ecuador, Quito, Ecuador, ³Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, ⁴Universidad de las Americas, Quito, Ecuador, ⁵Hospital General San Francisco IESS, Quito, Ecuador, ⁶Hospital Metropolitano, Quito, Ecuador, ⁷Universidad Central del Ecuador, Quito, Ecuador, ⁸Universidad Peruana Cayetano Heredia, Lima, Peru, ⁹Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, ¹⁰Department of Surgery, Duke University, Durham, NC, ¹¹Department of surgery, Duke University, Durham, NC
*Purpose: Living donor adult-to-adult liver transplantation (LT) has emerged as a feasible alternative to deceased donors. Advances in hepatobiliary surgery have allowed the introduction of…

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