Articles tagged "Liver transplantation"

2018 American Transplant Congress
Intestinal Microbiome Diversity is Associated with Liver Disease Etiology and Predicts Post-Liver Transplant Mortality
E. Verna, M. Annavajhala, M. Nenad, R. Brown, S. Sullivan, G. Korakani, M. Gidins, S. Khan, A. Gomez-Simmonds, A-.C. Uhlemann.
Medicine, Columbia University, New York, NY.
Background: Dysbiosis of the intestinal microbiome is common among patients with decompensated liver disease and has been associated with disease progression as well as life-threatening…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Post Reperfusion Portal Flow Rate Impacts Liver Allograft and Patient Survival in Patients with Pre Transplant Portal Vein Thrombosis
M. Rizzari, M. Safwan, M. Sobolic, S. Nagai, R. Schilke, K. Collins, A. Yoshida, M. Abouljoud.
Henry Ford Transplant Institute, Henry Ford Health System, Detroit, MI.
Background: Pre-transplant (pretx) portal vein thrombosis (PVT) not only makes the technical aspect of liver transplantation more challenging, it also is known to affect outcomes.…
2018 American Transplant Congress
Liver Transplant Survival Index for Recipients with High MELD Score: A Model for Post-Transplant Survival in Severely Ill Patients
J. Steggerda,¹ M. Bloom,¹ C. Bresee,² D. Malinoski,³ A. Klein,¹ K. Kim.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA; ³Surgery, Oregon Health Science University, Portland, OR.
Background: SHARE-35 prioritizes patients with MELD scores ≥35 for regional sharing of liver allografts. Because this policy incentivizes transplantation of sicker patients, this study examines…
2018 American Transplant Congress
Positive Relationship between Transplant Center Volume and Utilization of Hard to Place Liver Allografts after Late Declines
J. Knox,¹ H. Braun,¹ S. Syeed,¹ K. Halazun,² G. Roll.¹
¹Department of Transplant Surgery, UCSF, San Francisco, CA; ²Weill Cornell Medical Center, New York, NY.
Given ongoing waitlist mortality and the high rates of liver discard in the US we wanted to investigate late declines (LD), and very late declines…
2018 American Transplant Congress
Increased BMI is a Predictor of Early Post-Transplant Cardiac Events and Mortality
A. Mahgoub, S. Jackson, J. Lake, N. Lim.
Medicine, University of Minnesota, Minneapolis, MN; Transplant Information Services/ISR2, Fairview Health Services, Minneapolis, MN.
Background: Cardiac events (CVE) remain a significant source of morbidity in the early post-transplant(post-tx) period despite extensive evaluation prior to liver transplant(LT). It is important…
2018 American Transplant Congress
MELD-Na Score Based Liver Allocation: Hyponatremia is No Longer a Risk Factor for Waitlist Mortality
S. Nagai,¹ L. Chau,¹ M. Safwan,¹ R. Schilke,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ M. Abouljoud,¹ D. Moonka.²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI.
Background: Hyponatremia is associated with an increased risk of liver transplant (LT) waitlist mortality. The aim of this study was to compare waitlist outcomes between…
2018 American Transplant Congress
DSA-Level Liver Availability and Liver Utilization
S. Zhou, M. Bowring, A. Massie, S. Gentry, D. Segev.
The JHU, Baltimore.
DSA-level geographic disparity in access to deceased-donor liver transplantation is well described. However, understanding the relationship between liver availability in a DSA and exportation of…
2018 American Transplant Congress
Cost Analysis of Loco-Regional Bridging Therapy for Hepatocellular Carcinoma: A National Study
M. Nazzal,¹ R. Ouseph,¹ X. Huiling,¹ M. Schnitzler,¹ C. Varma,¹ H. Randall,¹ J. Tuttle-Newhall,² D. Axelrod,³ K. Lentine.¹
¹Abdominal Transplant, Saint Louis University Hospital, Saint Louis, MO; ²Surgery, East Carolina University/Brody School of Medicine, Greenville, NC.
Liver transplantation (LT) is cost-effective in the primary treatment of Hepatocellular carcinoma (HCC). Loco-regional therapies (LRTs) have increased as both primary therapy for HCC as…
2018 American Transplant Congress
Digital Health Education for the Pediatric Solid Organ Transplant Population
T. Nemeth,¹ J. Smith,² A. Pollack,² W. Swanson,³ E. Hsu.⁴
¹Pharmacy, Seattle Children's, Seattle; ²Nephrology, University of Washington, Seattle; ³Digital Health, Seattle Children's, Seattle; ⁴Hepatology, University of Washington, Seattle.
Background: Self-management and adherence are key factors that influence post transplant graft survival. Education after solid organ transplant plays an important role in providing patients…