Articles tagged "Liver transplantation"

2019 American Transplant Congress
Outcomes of Liver Transplantation for Hepatocellular Carcinoma in Septuagenarians
M. Najjar¹, K. Bruestle¹, P. Jiang¹, E. Lieberman¹, R. Hwang¹, A. Mathur¹, E. C. Verna¹, A. Griesemer¹, B. Samstein², T. Kato¹, Y. M. Saenger¹, K. J. Halazun², J. C. Emond¹
¹Columbia University Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: The impact of advanced age on liver transplantation (LT) for hepatocellular carcinoma (HCC) has not been well studied. We sought to compare post-OLT survival…
2019 American Transplant Congress
The Role of Non-Traditional Environmental Factors in Long-Term Outcomes of Liver Transplantation
J. Buggs¹, D. Patino², B. Evans¹, C. Anderson¹, C. Delfavero¹, E. Rogers¹, A. Alsina¹, A. Kumar³
¹Tampa General Hospital, Tampa, FL, ²University of Tampa, Tampa, FL, ³University of South Florida, Tampa, FL
*Purpose: The purpose of this research project was to evaluate the role of non-traditional subjective environmental factors in long-term outcomes of liver transplantation.*Methods: We conducted…
2019 American Transplant Congress
Lifelong Immunosuppression, I Am Sure We Told Them That?: Long Term Medication Adherence in Liver Transplant Patients
K. Foster¹, C. Perez¹, T. Harrison¹, H. Corbo¹, N. Patel¹, J. Fleming¹, H. Meadows¹, D. Taber¹, D. DuBay², J. McGillicuddy², N. Pilch¹
¹Department of Pharmacy Services, -Medical University of South Carolina, -Charleston, SC, ²Division of Transplant Surgery, Department of Surgery, -Medical University of South Carolina, -Charleston, SC
*Purpose: Current literature describes demographic information of non-adherent patients and identifies that non-adherence may be predictive of post-txp outcomes. We suspect that patients with private…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2018 American Transplant Congress
Intestinal Microbiome Diversity is Associated with Liver Disease Etiology and Predicts Post-Liver Transplant Mortality
E. Verna, M. Annavajhala, M. Nenad, R. Brown, S. Sullivan, G. Korakani, M. Gidins, S. Khan, A. Gomez-Simmonds, A-.C. Uhlemann.
Medicine, Columbia University, New York, NY.
Background: Dysbiosis of the intestinal microbiome is common among patients with decompensated liver disease and has been associated with disease progression as well as life-threatening…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Post Reperfusion Portal Flow Rate Impacts Liver Allograft and Patient Survival in Patients with Pre Transplant Portal Vein Thrombosis
M. Rizzari, M. Safwan, M. Sobolic, S. Nagai, R. Schilke, K. Collins, A. Yoshida, M. Abouljoud.
Henry Ford Transplant Institute, Henry Ford Health System, Detroit, MI.
Background: Pre-transplant (pretx) portal vein thrombosis (PVT) not only makes the technical aspect of liver transplantation more challenging, it also is known to affect outcomes.…
2018 American Transplant Congress
Liver Transplant Survival Index for Recipients with High MELD Score: A Model for Post-Transplant Survival in Severely Ill Patients
J. Steggerda,¹ M. Bloom,¹ C. Bresee,² D. Malinoski,³ A. Klein,¹ K. Kim.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA; ³Surgery, Oregon Health Science University, Portland, OR.
Background: SHARE-35 prioritizes patients with MELD scores ≥35 for regional sharing of liver allografts. Because this policy incentivizes transplantation of sicker patients, this study examines…
2018 American Transplant Congress
Positive Relationship between Transplant Center Volume and Utilization of Hard to Place Liver Allografts after Late Declines
J. Knox,¹ H. Braun,¹ S. Syeed,¹ K. Halazun,² G. Roll.¹
¹Department of Transplant Surgery, UCSF, San Francisco, CA; ²Weill Cornell Medical Center, New York, NY.
Given ongoing waitlist mortality and the high rates of liver discard in the US we wanted to investigate late declines (LD), and very late declines…
2018 American Transplant Congress
Increased BMI is a Predictor of Early Post-Transplant Cardiac Events and Mortality
A. Mahgoub, S. Jackson, J. Lake, N. Lim.
Medicine, University of Minnesota, Minneapolis, MN; Transplant Information Services/ISR2, Fairview Health Services, Minneapolis, MN.
Background: Cardiac events (CVE) remain a significant source of morbidity in the early post-transplant(post-tx) period despite extensive evaluation prior to liver transplant(LT). It is important…