Articles tagged "Liver transplantation"

2019 American Transplant Congress
CURATE.AI: Personalized Liver Transplant Tacrolimus Dosing
A. Zarrinpar¹, T. Kee², P. Wang³, J. Khong³, U. Kim¹, J. Chong², J. B. Jeong³, A. T. Truong², S. Tan², B. K. Betzler², W. Ng², C. Ho³, D. Ho²
¹Surgery, University of Florida, Gainesville, FL, ²National University of Singapore, Singapore, Singapore, ³UCLA, Los Angeles, CA
*Purpose: Transplant immunosuppressive regimens include multiple drugs with varying pharmacokinetics, metabolic pathways, and drug-drug interactions. This study aimed to use CURATE.AI, an artificial intelligence platform,…
2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
Early Tacrolimus Trough Concentration Variability Could Predict Rejection in Pediatric Liver Transplantation: A Single-Center and Retrospective Research
G. Gu, Q. Xia
Renji Hospital, Shanghai, China
*Purpose: With great development in immunosuppressive therapy, the long-term outcomes and survival time in patients who received solid organ transplantation have been improved remarkably. The…
2019 American Transplant Congress
Adjuvant Immunotherapeutic Approach For Liver Transplant Recipients With Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells
M. Ohira¹, R. Hotta¹, Y. Imaoka¹, K. Sato¹, Y. Tanaka¹, A. G. Tzakis², S. Nishida³, H. Ohdan¹
¹Hiroshima University, Hiroshima, Japan, ²Cleveland Clinic Florida, Weston, FL, ³New York Medical College, Valhalla, NY
*Purpose: Although liver transplantation (LT) is a preferred treatment for selected patients with Hepatocellular carcinoma (HCC), HCC-recurrence would be a still important medical problem. Most…
2019 American Transplant Congress
Surgeon Readiness For Entry Into Practice: A Survey Of Abdominal Transplant Surgeons In The United States
M. Abouljoud¹, R. Hirose², S. Nagai¹, C. Gordon³, D. Farmer⁴
¹Henry Ford Transplant Institute, Detroit, MI, ²Transplant Surgery, University of California San Francisco, San Francisco, CA, ³American Society of Transplant Surgeons, Arlington, VA, ⁴Transplant Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA
*Purpose: The American Society of Transplant Surgeons (ASTS) provides a framework for the training and development of a competent transplant surgery workforce. Practice-readiness and phase-in…
2019 American Transplant Congress
Identification Of Pre-transplant Biomarkers Of Recipient Immune Dysfunction That Predict Recipient Risk Of Death Following Liver Transplant: The Immune Frailty Index
K. E. Lunsford¹, N. Aware¹, K. Cleveland¹, C. J. Manner¹, D. T. Nguyen², E. A. Graviss², J. V. Thomas¹, H. Vyas¹, L. W. Moore¹, S. A. Dorman¹, A. Saharia¹, C. M. Mobley¹, M. J. Hobeika¹, X. C. Li¹, R. M. Ghobrial¹
¹Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Houston, TX, ²Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction is well recognized and likely contributes to early mortality following liver transplant (LT) resulting from infections; however, few prior studies have…
2019 American Transplant Congress
Women Who Undergo Liver Transplant Have Increased Health Care Utilization in the Peri-Transplant Period Compared with Men
J. B. Rubin, G. Cullaro, J. Ge, J. C. Lai
Department of Medicine, Division of Gastroenterology & Hepatology, Univeristy of California-San Francisco, San Francisco, CA
*Purpose: We have previously shown that women on the liver transplant (LT) waitlist are at greater risk of hospitalization compared with men, but whether this…
2019 American Transplant Congress
Intraoperative Portal Vein Flow Can Predict Early Acute Kidney Injury Following Allogeneic Liver Transplantation: A Retrospective Observational Study
J. Zhang¹, A. Jiao², Q. Liu¹, C. Zhang¹, N. Sun¹, X. Li¹
¹Hepatobiliary Surgery Department and Unit of Organ Transplantation, The First Hospital of China Medical University, Shenyang, China, ²Department of Hepato-Biliary-Pancreatic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China
*Purpose: Acute kidney injury (AKI) is a major and severe complication following allogeneic orthotopic liver transplantation (OLT) and is associated with increased postoperative morbidity and…
2019 American Transplant Congress
Feasibility of a Rapid Magnetic Resonance Protocol to Assess Body Composition Profiles in Adult Liver Transplant Candidates
S. Pine¹, L. Adamski¹, D. Gregory¹, C. Padilla¹, J. Gottstein², A. Lemmer¹, M. Forsgren³, M. Rinella¹, L. B. VanWagner⁴
¹Medicine-GI & Hepatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Center for Medical Image Science, Linköping University, Linköping, Sweden, ⁴Medicine-GI & Hepatology and Preventive Medicine, Northwestern University, Chicago, IL
*Purpose: Body mass index (BMI) is a poor marker of obesity and outcomes in liver transplant (LT) candidates. Data suggest that body composition profiling (BCP),…
2019 American Transplant Congress
Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation
M. Chen, M. Han, W. Ju, Q. Zhao, D. Wang, Z. Guo, X. He
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…