2022 American Transplant Congress
Secular Trends in Development of ESRD Following Liver Transplant
*Purpose: End-stage renal disease (ESRD) post-liver transplant (LT) is associated with increased mortality, but ESRD incidence and risk factors in LT recipients (LTRs) remain poorly…2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…2022 American Transplant Congress
Successful Utilization of Advanced Diabetes Technology to Optimize Glucose Control as a Bridge to Simultaneous Liver and Pancreas Transplantation
*Purpose: We present the case of a 20 year old female with history of autoimmune hepatitis diagnosed in 2014, treated with tacrolimus, and insulin dependent…2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…2022 American Transplant Congress
Temporal Trends of Optn Hope Act Variance Participation
*Purpose: The Organ Procurement and Transplantation Network (OPTN) created a research variance allowing for transplantation of HIV+ donor kidneys and livers into HIV+ recipients after…2022 American Transplant Congress
A Population-Based Analysis of Long-Term Outcomes Following Pediatric Acute Liver Failure Highlights High Risk Populations in Access to Transplant
*Purpose: Pediatric acute liver failure (PALF) is a potentially devastating illness that affects otherwise healthy children. Nearly 70% of children with PALF will recover, while…2022 American Transplant Congress
Portal Vein Thrombosis and DCD Liver Transplantation: Dangerous Combination or Clinical Opportunity?
*Purpose: Individually, recipient portal vein thrombosis (PVT) and donation after circulatory death (DCD) allografts are associated with a higher risk of poor deceased donor liver…2022 American Transplant Congress
Outcomes Following Liver Re-Transplantation for Delayed Graft Loss in Recipients of Donation After Circulatory Death Allografts in the United States
*Purpose: Donation after circulatory death (DCD) liver transplant (LT) recipients have a higher likelihood of delayed graft loss due to Ischemic cholangiopathy (IC). Limited data…2022 American Transplant Congress
Perioperative Management of Live Donor Liver Transplantation: National Survey Results
*Purpose: Living donor liver transplantation (LDLT) is an emerging alternative for deceased donor liver transplantation (DDLT). In the United States (US), LDLT represented 5.3% (442/8345)…2022 American Transplant Congress
Single Cell Transcriptomics Reveal Allograft Immune Cell Patterns Associated with Histological Features of Acute Cellular Rejection in Liver Transplantation
*Purpose: Development of successful tolerance induction strategies using immune cell-based therapies in transplantation depends on improved understanding of the local intra-graft cellular milieu that underlies…
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