Articles tagged "Liver transplantation"

2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Childrens Hosp, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, ¹³Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
2022 American Transplant Congress
Impact and Consequences of Recipient Gastroduodenal Artery (GDA) Ligation Prior to Hepatic Artery (HA) Anastomosis During Orthotopic Liver Transplantation (OLT)
A. Kumar, D. Gerber, C. Desai
Abdominal Transplant Surgery, UNC School of Medicine, Chapel Hill, NC
*Purpose: The recipient GDA is often ligated before the HA anastomosis during OLT either to gain mobility, length on recipient HA and with hypothesis that…
2022 American Transplant Congress
Integrated Alcohol Use Disorder Clinic as a Strategy to Reduce Alcohol Relapse After Early Liver Transplantation in Patients with Alcohol Related Liver Disease
R. Z. Syed¹, C. Albers², N. Kemmer², V. Subramanian², C. Machado-Denis¹, K. Dhanireddy²
¹Hepatology and Liver Transplantation, Tampa General Hospital, Tampa, FL, ²Tampa General Hospital, Tampa, FL
*Purpose: In recent years, for patients with Alcohol related Liver Disease (ALD), there has been a trend towards early Liver Transplantation (LT) rather than waiting…
2022 American Transplant Congress
Tracheostomy After Liver Transplantation: Utility and Impact
D. Noguchi, V. M. Nguyen, C. J. Rosenthal, V. G. Agopian, D. G. Farmer, F. M. Kaldas
Liver and Pancreas Transplant Center, UCLA, Los Angeles, CA
*Purpose: High acuity Liver transplant (LT) patients have an increased risk of postoperative respiratory failure requiring tracheostomy (TS). The use of TS in ventilator-dependent patients…
2022 American Transplant Congress
Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Solid Organ Transplant
H. Sweiss¹, D. Zeilmann¹, J. Escamilla², R. Hall¹, S. Bhayana¹, R. Patel¹, C. Long²
¹University Health - University Hospital, San Antonio, TX, ²College of Pharmacy, University of Incarnate Word, San Antonio, TX
*Purpose: To evaluate the safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP1-RA) in solid organ transplant (SOT).*Methods: This retrospective review included adult kidney, liver,…
2022 American Transplant Congress
Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients
N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ²Hiroshima University, Hiroshima, Japan
*Purpose: High-mobility group box 1 (HMGB-1) is an inflammatory mediator which becomes an uncontrollable lethal factor when released in excess from the nucleus or the…
2022 American Transplant Congress
Evolution of the Need for Transplant Evaluations for Liver Failure Decompensation After TIPS
N. Kemmer¹, V. Sureshkumar², L. Grater³, G. Hoots⁴, S. Agrawal¹, K. Robichaux⁵, M. Gosselin³, S. Mohammed⁵, A. Kumar⁶, J. Buggs⁷
¹Transplant Hepatology, Tampa General Hospital, Tampa, FL, ²Lake Erie College of Osteopathic Medicine, Bradenton, FL, ³University of Tampa, Tampa, FL, ⁴Radiology, Tampa General Hospital, Tampa, FL, ⁵University of South Florida, Tampa, FL, ⁶Morsani College of Medicine, University of South Florida, Tampa, FL, ⁷Transplant Surgery, Tampa General Hospital, Tampa, FL
*Purpose: Portal hypertension is described as an increased pressure gradient between the portal and systemic circulation which can result in severe complications. Transjugular Intrahepatic Portosystemic…
2022 American Transplant Congress
Association Between CT Measurements of Body Composition Before Liver Transplantation and Post-Transplantation Outcomes
Y. Liu¹, O. Shafaat¹, K. Jackson¹, J. Motter¹, B. Boyarsky¹, M. Latif¹, F. Yuan¹, E. King¹, A. Zaheer¹, R. Summers², D. Segev¹, M. McAdams-DeMarco¹, C. Weiss¹
¹Johns Hopkins University, Baltimore, MD, ²NIH Clinical Center, Bethesda, MD
*Purpose: Various methods exist for measuring body composition using computed tomography (CT) scans; however, it is unclear which components best predict post-liver transplantation (LT) outcomes.…
2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
M. D. Nazzal¹, K. Kurashima², J. Bettag², A. Chen², S. Bruno², A. Nagarapu², J. Van Nispen¹, J. Krebs², J. Teckman², D. Carpenter³, D. Hermelin³, C. Varma¹, A. Jain²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pediatrics, Saint Louis University, Saint Louis, MO, ³Pathology, Saint Louis University, Saint Louis, MO
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…
2022 American Transplant Congress
Normothermic Machine Perfusion in Liver Transplantation – Seven Year Experience at a Single North American Centre
J. Hefler¹, D. L. Izuierdo¹, G. Meeberg², M. Bral¹, B. Anderson¹, K. Dajani¹, N. Kneteman¹, D. L. Bigam¹, A. Shapiro¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada, ²Alberta Health Services, Edmonton, AB, Canada
*Purpose: Machine perfusion for preservation of liver grafts before transplantation has risen in prominence over the past decade. Normothermic machine perfusion (NMP), in particular, has…

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