Articles tagged "Liver transplantation"

2020 American Transplant Congress
Should Steatotic Livers Be Transplanted Into Pediatric Recipients?
M. MacConmara, C. Feizpour, P. Vagefi, C. Ramirez, L. DeGregorio, C. S. Hwang
UT Southwestern, Dallas, TX
*Purpose: Although steatotic livers are frequently transplanted in the adult population, they are not commonly transplanted in pediatric recipients. We questioned if the outcomes of…
2020 American Transplant Congress
Characterizing the Waitlist Candidate Who Was Bypassed by the Successfully Transplanted Candidate with Alcoholic Hepatitis
J. Ge¹, C. L. Berg², F. Y. Yao¹, J. P. Roberts³, J. C. Lai¹
¹Medicine - Gastroenterology, University of California, San Francisco, San Francisco, CA, ²Duke University, Durham, NC, ³Surgery, University of California, San Francisco, San Francisco, CA
*Purpose: Early liver transplantation (LT) for acute alcoholic hepatitis (AH) has increased dramatically in the US since 2016. Due to high MELD-Na scores, AH candidates…
2020 American Transplant Congress
Muscle-Liver Crosstalk via the Myokine MG53 Plays a Critical Role in Hepatocellular Repair
C. Akateh, J. Ko, B. F. Reader, J. Kim, Y. Lee, B. A. Whitson, J. Ma, S. M. Black
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Transplantation remains the only effective treatment for end-stage liver disease, but the number of organs deemed suitable for transplantation falls far short of the…
2020 American Transplant Congress
Perioperative Opioid Avoidance in Liver Transplant Recipients: Significant Reduction in Opioid Use Through a Multidiscplinary, Multimodal Approach
H. Kutzler, R. Gannon, W. Nolan, L. Meisterling, M. Cech, D. Gleason, J. Uzl, C. Rochon, B. Maneckshana, O. Serrano, J. Riley, D. O'Sullivan, E. Urtasun-Sotil, M. Einstein, P. Sheiner
Hartford Hospital, Hartford, CT
*Purpose: Given the association between substance use disorder and risk of post-surgical opioid use disorder, we developed an opioid avoidance pathway (OAP) in adult liver…
2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Bruestle¹, F. Fredriksson¹, J. Stern¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
2020 American Transplant Congress
Renal Function Parameters Improve PELDs Prediction of 90-day Death or Deterioration
L. Thalji¹, N. Thalji², D. Haile¹, J. Heimbach², S. Ibrahim³, P. Kamath⁴, D. Kor¹
¹Anesthesiology, Mayo Clinic, Rochester, MN, ²Surgery, Mayo Clinic, Rochester, MN, ³Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, ⁴Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: Reliance upon exception points to prioritize children for liver transplantation (LT) stems from concerns that the Pediatric End-Stage Liver Disease (PELD) score underestimates mortality.…
2020 American Transplant Congress
Evaluating the Efficacy of Robotic-Assisted Incisional Hernia Repair for Post-Liver Transplant Recipients
G. Rofaiel, G. Pan, M. Goodale, E. Martinez
University of Utah, Salt Lake City, UT
*Purpose: Hernia formation is a well-known complication following open abdominal surgery that contributes to post-operative morbidity and decreases in patient quality of life. Herein we…
2020 American Transplant Congress
Waiting List Mortality of Liver Tumors
V. G. Menon, Y. Chen, D. C. Chang, H. Yeh
Division of Transplantation, Massachusetts General Hospital, Boston, MA
*Purpose: Liver transplantation has been approved for hepatocellular carcinoma (HCC), hilar cholangiocarcinoma (CCA) and metastatic neuroendocrine tumors (NET), with the aim to produce similar outcomes…
2020 American Transplant Congress
Myosteatosis and its Impact on Graft- and Patient Survival in Adult Recipients of Deceased Donor Liver Transplantation
Z. Czigany, W. Kramp, G. van der Kroft, P. Strnad, M. Zimmermann, W. Liu, G. Wiltberger, U. Neumann, G. Lurje
University Hospital RWTH Aachen, Aachen, Germany
*Purpose: Recently our group demonstrated the role of myosteatosis in inferior perioperative outcomes (Czigany et al. Am J Transplant 2019) in recipients of orthotopic liver…
2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…