Articles tagged "Liver transplantation"

2020 American Transplant Congress
Pig-To-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine
D. Detelich¹, C. G. Rickert¹, T. M. Coe¹, S. Kimura¹, I. Rosales¹, H. Deng¹, H. Yeh¹, W. Qin², Y. Kan², J. Layer², M. Youd², W. Westlin², L. Yang², J. F. Markmann¹
¹Massachusetts General Hospital, Boston, MA, ²eGenesis, Cambridge, MA
*Purpose: Pig-to-baboon liver xenotransplant (LXT) continues with significant hurdles, including thrombocytopenia, coagulation dysregulation and rejection with the longest reported survival of 29 days utilizing a…
2020 American Transplant Congress
Treprostinil is Safe and Potentially Useful in Preventing Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients
R. Venkataramanan¹, I. H. Shaik², V. C. Pillai³, O. A. Almazroo⁴, M. K. Miah⁵, R. Xu², S. Dharmayan², A. Al-Khafaji², S. Ganesh², M. Molinari², A. Tevar², C. Hughes², A. Humar²
¹School Of Pharmacy, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³US Food and Drug Administration,, Silver Spring, MD, ⁴Saudi FDA, Riyadh, Saudi Arabia, ⁵Astra Zeneca, Boston, MA
*Purpose: Ischemia and reperfusion injury (IRI) is one of the unavoidable complications in orthotopic liver transplantion. Hepatic ischemic injury begins during the preservation of the…
2020 American Transplant Congress
Maternal Peripartum Complications in Solid Organ Transplantation
R. X. Wang¹, G. S. Lee-Riddle², D. O. Walls³, D. S. Goldberg⁴, P. L. Abt²
¹Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, ²Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³Department of Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ, ⁴Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
*Purpose: Previous studies examining pregnancy related complications after solid organ transplantation (SOT) primarily relied on voluntary registries and meta-analyses. Herein, we investigated maternal delivery outcomes…
2020 American Transplant Congress
Progression of Insulin Resistance after Liver Transplantation – Prospective Study
I. Mikova¹, D. Erhartova¹, K. Dvorakova¹, P. Sedivy², M. Drobny², M. Dezortova², M. Hajek², M. Cahová³, H. Dankova³, E. Sticova⁴, V. Lanska⁵, P. Trunecka¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ³Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Insulin resistance (IR) plays an important role in pathogenesis of nonalcoholic fatty liver disease (NAFLD) and other diseases. The data about prevalence and evolution…
2020 American Transplant Congress
Improvement of Renal Function Prior to Liver Transplantation is Not Associated with Better Long-Term Renal Outcome or Mortality
M. Sterneck¹, T. Horvatits², M. Touma², U. Herden³, A. Lohse², L. Fischer³
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: Since introduction of the MELD score in the liver allocation system, renal impairment in OLT recipients has become a topic of increasing importance. This…
2020 American Transplant Congress
Hepatic Artery Thrombosis in the Modern Era of Increased Utilization of Livers from Older Donors
A. Kernodle, M. Krach, P. Chiang, D. Segev, A. Massie, J. Garonzik-Wang
Johns Hopkins Hospital, Baltimore, MD
*Purpose: In a prior study using national registry data, deceased donor age greater than 50 was associated with a 35% to 61% increased risk of…
2020 American Transplant Congress
Relationship between Tacrolimus Levels and Short-Term Outcome in Korean Pediatric Patients with Liver Transplantation
H. Lim¹, H. Koh¹, S. Kim¹, S. Park¹, Y. Kang², M. Kim³, K. In¹
¹Severance Pediatric Liver Diseases Research Group, Severance Children’s Hospital, Severance Hospital, Seoul, Korea, Republic of, ²Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, , Wonju Severance Christian Hospital, Seoul, Korea, Republic of, ³Division of Transplantation Surgery, Department of General Surgery, Severance Hospital, Seoul, Korea, Republic of
*Purpose: Liver transplantation (LT) is a life-saving procedure in patients with end stage liver disease. After LT, immunosuppresive regimens are needed in order to prevent…
2020 American Transplant Congress
Impact of County Health Rankings on Nationwide Liver Transplant Outcomes
S. K. Niazi¹, E. Vargas², A. Spaulding³, J. Crook⁴, A. P. Keaveny⁵, T. Schneekloth⁶, T. Rummans⁷, C. Taner⁵
¹Psychiatry & Psychology; Transplantation, Mayo Clinic, Jacksonville, FL, ²Heath Services Research, Mayo Clinic, Jacksonville, FL, ³Health Services Research, Mayo Clinic, Jacksonville, FL, ⁴Health Sciences Research, Mayo Clinic, Jacksonville, FL, ⁵Transplantation, Mayo Clinic, Jacksonville, FL, ⁶Psychiatry & Psychology, Mayo Clinic, Rochester, MN, ⁷Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL
*Purpose: We examined the impact of social determinants of health (SDOH) in LT recipients’ counties of residence and their associations with long-term patient and graft…
2020 American Transplant Congress
Validation of the Graft Volume Formula Avoiding Small-for-Size Graft Dysfunction in Adult to Adult Living Donor Liver Transplantation
A. Nishimagi, N. Sato, Y. Kofunato, T. Ishigame, R. Okada, T. Kimura, A. Kenjo, S. Marubashi
Department of Hepato-Biliary-Pancreatic and Transplant Surgery, Fukishima Medical University, Fukushima, Japan
*Purpose: It is important to determine the optimal volume of liver graft in living donor liver transplantation(LDLT) for avoiding small-for-size graft syndrome(SFSS) A formula of…
2020 American Transplant Congress
Adenovirus Infection in Pediatric Liver Transplant Recipients: A Single Center Experience
S. Hassan¹, K. R. Mysore¹, M. E. Faraone², D. Cerminara³, K. Hosek⁴, E. Moulton⁵, C. Bocchini⁵, R. Sigereddi⁶, R. Ackah⁶, F. Muñoz⁵, A. Rana⁷, J. Goss⁷, D. H. Leung¹, T. Galvan⁷
¹Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ²Department of Surgery, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ³Department of Pharmacy, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁴Outcomes and Impact Service, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁵Department of Pediatrics, Infectious Diseases, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁷Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
*Purpose: Immunosuppression predisposes children to primary viral or latent infections after liver transplantation (LT). The impact of adenovirus infections on morbidity and mortality remains largely…