Articles tagged "Liver transplantation"

2020 American Transplant Congress
Living versus Deceased Donor Liver Transplantation in Cholestatic Liver Disease: An Analysis of the OPTN Database
I. A. Ziogas¹, S. P. Alexopoulos¹, L. K. Matsuoka¹, S. K. Geevarghese¹, L. D. Gorden¹, S. J. Karp¹, J. D. Perkins², M. I. Montenovo¹
¹Vanderbilt University Medical Center, Nashville, TN, ²University of Washington, Seattle, WA
*Purpose: The current MELD allocation system does not accurately reflect the urgency of liver transplantation (LT) in cholestatic liver disease (CLD) patients. Therefore, more CLD…
2020 American Transplant Congress
Hypernatremia Predicts Waitlist Death and Deterioration, but Not Post-Transplant Outcomes in Pediatric Liver Transplant Candidates
L. Thalji¹, N. Thalji², S. Ibrahim³, J. Heimbach², P. Kamath⁴, D. Haile¹, D. Kor¹
¹Anesthesiology, Mayo Clinic, Rochester, MN, ²Surgery, Mayo Clinic, Rochester, MN, ³Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, ⁴Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: Pre-transplant hypernatremia has been shown to predict post-transplant mortality in adult liver transplant (LT) recipients. The effects of hypernatremia in children, however, remain unexplored.…
2020 American Transplant Congress
Characterization of a Clinically Scaled Bioengineered Liver Seeded with Primary Hepatocytes and Endothelial Cells
D. S. Davidow¹, J. J. Ross¹, B. D. Anderson¹, A. Stumbras¹, A. A. Katane¹, R. Lindeman¹, B. G. Steiner¹, A. Mendenhall¹, K. Gahlbeck¹, S. Armstrong¹, B. P. Amiot², E. D. Nelson², T. Gilbert¹, S. L. Nyberg²
¹Miromatrix, Eden Prairie, MN, ²Mayo Clinic, Rochester, MN
*Purpose: Advancements in whole organ bioengineering have the potential to offer solutions to a chronically insufficient donor organ supply. We recently demonstrated an ability to…
2020 American Transplant Congress
Increasing Prevalence and Diversity: Alcoholic Liver Disease in Liver Transplant Candidates
M. Joshi, E. L. Godfrey, J. A. Goss, A. Rana
Baylor College of Medicine, Houston, TX
*Purpose: Increasing global alcohol use translates to a marked growth in alcoholic liver disease (ALD). ALD patients comprise a larger proportion of listings for liver…
2020 American Transplant Congress
Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation
K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
Biliary Reconstructionwith High Biliary Radicals is Safe Option for Multiple Graft Bile Ducts in Right Lobe Living Donor Liver Transplantation
J. Kim, D. Choi, E. Jwa
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Korea, Republic of
*Purpose: Multiple small size donor bile ducts (BDs) are related to higher incidence of biliary complications (BCs) and biliary reconstruction for multiple BDs still remains…
2020 American Transplant Congress
The Efficacy and Safety of Ischemia-Free Liver Transplantation (IFLT) in the Treatment of End-Stage Liver Disease in a Prospective, Randomized, Controlled Trial: A Report of the First 25 Cases
X. He, Z. Guo, Q. Zhao, C. Huang, W. Ju, D. Wang, M. Chen, L. Wu, Y. Ma, Y. Chen, A. Hu, X. Zhu
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: We’ve established a novel procedure called ischemia-free liver transplantation (IFLT). The results from the pilot study suggest that IFLT might prevent ischemia-reperfusion injury (IRI)…
2020 American Transplant Congress
Pre-Transplant Overt Hepatic Encephalopathy is Associated with Greater Cognitive Improvement after Liver Transplant
M. Kim¹, J. Menzel-Smith¹, J. D. Peipert², K. J. Reid¹, P. Zee¹, D. P. Ladner³
¹Neurology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Surgery, Northwestern University, Chicago, IL
*Purpose: Persistent or residual cognitive impairment following liver transplant is frequently reported yet not well-characterized.*Methods: Cognitive function was tested in a prospective cohort of patients…
2020 American Transplant Congress
HCC Liver Transplantation Waitlist Dropout Rates before and after the Mandated Six-Month Wait-Time
M. LaVere¹, K. Robichaux², J. Buggs³, E. Rogers³, S. Nyce⁴, A. Kumar¹, J. Sokolich³
¹Morsani College of Medicine, University of South Florida, Tampa, FL, ²Honors College, University of South Florida, Tampa, FL, ³Transplant Surgery, Tampa General Hospital, Tampa, FL, ⁴University of Tampa, Tampa, FL
*Purpose: Studies have shown significant improvement in hepatocellular carcinoma (HCC) recurrence rates following the UNOS implementation of a six-month wait period. However, few have examined…