Articles tagged "Liver transplantation"

2020 American Transplant Congress
A Three-Decade Analysis of Pancreatic Adenocarcinoma Following Liver Transplantation
O. Y. Mousa¹, J. E. Corral², K. Wijarnpreecha², R. Shah³, V. S. Louwagie⁴, M. J. Bartel⁵, B. Brahmbhatt²
¹Mayo Clinic, Rochester, MN, ²Mayo Clinic, Jacksonville, FL, ³Emory University, Atlanta, GA, ⁴Mayo Clinic Health System, Mankato, MN, ⁵Fox Chase Cancer Center, Philadelphia, PA
*Purpose: Liver transplant (LT) recipients are at risk of serious long term complications, including a higher risk of de novo malignancies compared to the general…
2020 American Transplant Congress
Normothermic Machine Perfusion of Genetically Modified Pig Livers with Human Blood
D. Detelich¹, T. M. Coe², C. G. Rickert², C. Carroll², N. Serifis², R. Matheson², I. Rosales², W. Qin³, Y. Kan³, J. Layer³, M. Youd³, W. Westlin³, S. Kimura², A. Azimzadeh², L. Yang³, J. F. Markmann²
¹Tufts Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³eGenesis, Cambridge, MA
*Purpose: Barriers to pig-to-human liver xenotransplantation remain, including profound thrombocytopenia, coagulopathy, and rejection. We utilized ex-vivo liver xenoperfusion with human blood to study the human…
2020 American Transplant Congress
Hepaticojejunostomy versus Duct to Duct Anastomosis in Liver Transplantation: An Old Question Revisited
A. M. Elsabbagh, M. T. Shamaa, A. Al-Kurd, F. Tinney, T. Ivanics, A. Mohamed, K. Delvecchio, S. Yeddula, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, S. Nagai
Henry Ford Hospital, Detroit, MI
*Purpose: Two surgical techniques are currently used for biliary reconstruction and each has its advantages/disadvantages. However, it is unclear if the used technique can impact…
2020 American Transplant Congress
Risk Factors Associated with Hepatic Artery Thrombosis in the Modern Era
M. Krach, A. Kernodle, P. Chiang, D. Segev, A. Massie, J. Garonzik-Wang
Johns Hopkins, Baltimore, MD
*Purpose: Historically, hepatic artery thrombosis (HAT) has been associated with certain risk factors, such as donor age, cold ischemia time, and split grafts; it is unclear…
2020 American Transplant Congress
Because That is Not How The Hierarchy Works: Primary Care Provider Perspectives on Liver Transplant Referral and Access to Transplant
V. Madabhushi¹, A. Murphy², C. Reams³, R. Gedaly³, M. Shah³, N. Pope⁴, M. Gupta⁵
¹General Surgery, University of Kentucky, Lexington, KY, ²University of Kentucky, College of Medicine, Lexington, KY, ³Surgery, DIvision of Transplant Surgery, University of Kentucky, Lexington, KY, ⁴University of Kentucky, College of Social Work, Lexington, KY, ⁵Surgery, Division of Transplant Surgery, University of Kentucky, Lexington, KY
*Purpose: In rural America, the road to obtaining a liver transplant (LTX) often starts at the primary care provider’s (PCP) office. Patients in rural communities…
2020 American Transplant Congress
Single Cell RNA Sequencing Analysis of 3 Human Living-Donor Liver Transplant Allograft Biopsies after Infusion of Donor-Derived Regulatory Dendritic Cells
L. M. Tran¹, T. Tabib², A. F. Zahorchak¹, R. Lafyatis², M. A. Styn¹, A. Humar¹, F. G. Lakkis¹, D. M. Metes¹, A. W. Thomson¹
¹Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Department of Medicine and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Single-cell RNA sequencing is an emerging, powerful genomic technology that can describe heterogenous cellular populations of whole solid organs with high resolution. We report…
2020 American Transplant Congress
Temporal Trends in the Incidence and Impact of Biliary Complications Following Liver Transplantation
K. R. Jackson¹, K. Lentine², M. Schnitzler², Z. Zhang², H. Xiao², J. Motter¹, D. Axelrod³, D. Segev¹
¹Johns Hopkins University, Baltimore, MD, ²Saint Louis University, Saint Louis, MO, ³University of Iowa, Iowa City, IA
*Purpose: Biliary complications (BC) are a major threat to successful liver transplantation (LT), as they are associated with a subsequent higher risk of mortality and…
2020 American Transplant Congress
Pediatric Liver Post-Transplant Length of Stay Index
T. Zhang¹, S. Barrett¹, R. Cotton², T. Galvan², J. Vierling², C. O'Mahony², J. Goss², A. Rana²
¹Medical Student, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Houston, TX
*Purpose: PELD scores are used to reduce waitlist mortality, but they do not accurately predict likelihood of prolonged length of stay or higher costs associated…
2020 American Transplant Congress
Inactive Status Change is an Independent Predictor of Waitlist Mortality and Disproportionately Impacts Patients in Donor Service Areas with a Higher Median MELD at Transplant
R. Batra¹, S. Noreen², D. Stewart³, D. Haakinson¹, G. Gan³, Y. Deng³, S. Kulkarni¹
¹Surgery, Yale University School of Medicine, New Haven, CT, ²UNOS, Richmond, VA, ³Yale University, New Haven, CT
*Purpose: Liver waitlist mortality is calculated by including both active and inactive patients. As inactive patients are unable to receive organ offers, models that adjust…
2020 American Transplant Congress
Liver Live Donor Champion: Advocacy Training to Facilitate Identification of Live Liver Donors
A. D. Love¹, L. R. Herbst¹, D. R. Helfer¹, L. Kurman², M. G. Bowring¹, S. R. Weeks¹, E. King¹, D. L. Segev¹, J. Garonzik Wang¹
¹Surgery, The Johns Hopkins School of Medicine, Baltimore, MD, ²Surgery, The Johns Hopkins Hospital, Baltimore, MD
*Purpose: Although live donor liver transplantation (LDLT) may help address organ shortage, patients lack knowledge about living donation and are reluctant to speak to potential…