Articles tagged "Liver transplantation"

2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…
2020 American Transplant Congress
Factors Associated with Hepatocellular Carcinoma Understaging for Liver Transplantation, and Variation in Understaging by Transplant Center
N. Mahmud¹, M. Hoteit¹, D. Goldberg²
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²University of Miami, Miami, FL
*Purpose: Hepatocellular carcinoma (HCC) may be cured by liver transplantation (LT) in selected patients, though recurrence rates remain high. Patients who are reported as within…
2020 American Transplant Congress
Predictors of Estimated GFR and Recurrent Chronic Kidney Disease (CKD) after Simultaneous Liver and Kidney Transplantation (SLKT): Results from the US Multicenter SKLT Consortium
P. Sharma¹, Z. Sui¹, M. Zhang¹, J. Magee¹, P. Barman², Y. Patel³, K. Walters⁴, S. Biggins⁵, A. Schluger⁶, G. Cullaro⁷, R. Wong⁸, J. Lai⁸, J. Jo⁹, J. Sinha⁹, L. VanWagner⁹, E. Verna⁷
¹Michigan Medicine, Ann Arbor, MI, ²UCSD, San Diego, CA, ³Duke, Durham, NC, ⁴UCLA, LA, CA, ⁵University of Washington, Seattle, WA, ⁶Westchester Medical Center, Weschester, NY, ⁷Columbia, New York, NY, ⁸UCSF, San Francisco, CA, ⁹Northwestern, Chicago, IL
*Purpose: SLKT is a life-saving intervention for patients with decompensated cirrhosis and concomitant end stage renal disease, irreversible acute kidney injury and select inherited metabolic…
2020 American Transplant Congress
A Data-Driven Approach to Defining the Volume-Outcome Relationship in Liver Transplantation
M. D. Bailey, E. L. Godfrey, W. C. Frankel, A. Rana
Baylor College of Medicine, Houston, TX
*Purpose: Patients with end-stage liver disease (ESLD) who undergo liver transplantation experience significant survival benefit, with a 1-year survival rate after liver transplantation of 91%.…
2020 American Transplant Congress
Black Patients with Cirrhosis Have Worse Liver-Related Outcomes: A Large Multicenter Study
N. R. Mazumder¹, K. Atiemo², K. Jackson³, A. Daud⁴, A. Kho³, L. G. Gabra⁵, J. Levitsky¹, D. P. Ladner⁴
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Department of Surgery, Tulane Abdominal Transplant Institute, New Orleans, LA, ³Center for Health Information Partnerships, Northwestern University, Chicago, IL, ⁴Transplant Surgery, Northwestern University, Chicago, IL, ⁵Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: Racial disparity is influential in liver cirrhosis. Estimates of its magnitude have been limited by lack of large, longitudinal data that track patients from…
2020 American Transplant Congress
Single-Cell RNA Sequencing Reveals Gene Expression Profiling of Ischemia Reperfusion Injury
L. Wang, S. He, J. Xu, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation is an important factor that leads to graft dysfunction and even recipient death. This study aims to explore…
2020 American Transplant Congress
Concurrent Final Acceptance Associated with Decreased Deceased Donor Liver Utilization
A. Robinson¹, K. Shutterly², M. Sellers³, J. Rosendale¹, D. Brockmeier⁴
¹United Network for Organ Sharing, Richmond, VA, ²Center for Organ Recovery and Education, Pittsburgh, PA, ³Emory University Hospital and LifeLink of Georgia, Atlanta, GA, ⁴Mid-America Transplant Services, St. Louis, MO
*Purpose: With broader sharing for candidates with high MELD scores, it is not unusual for liver candidates to receive offers from multiple donors. Accepting multiple…
2020 American Transplant Congress
Impact of Donation after Circulatory Death Allografts on Outcomes Following Liver Re-Transplantation in the United States
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Scarcity of donor organs in liver transplantation (LT) has necessitated consideration of donation after circulatory death (DCD) donors. Complications following LT and disease recurrence…
2020 American Transplant Congress
Acute Liver Failure Requiring Liver Transplantation Due to Acute Hepatitis A Infection: A Case Series
C. Xie¹, J. M. Fenkel¹, D. L. Halegoua-DeMarzio¹, J. M. Civan¹, D. M. Tholey¹, S. K. Herrine¹, M. Thapar¹, S. Arastu¹, A. M. Frank², A. P. Shah², J. M. Glorioso², C. G. Ramirez², A. S. Bodzin², W. R. Maley², D. A. Sass¹
¹Gastroenterology and Hepatology, Thomas Jefferson University, Philadelphia, PA, ²Transplant Surgery, Thomas Jefferson University, Philadelphia, PA
*Purpose: On August 1, Philadelphia declared a public health emergency regarding rapid increases in new acute hepatitis A virus (HAV) cases, with 355 locally-acquired cases…
2020 American Transplant Congress
Risk Prediction in the Meld-NA Era: The Tremendous Impact of Liver Related Complications
N. R. Mazumder¹, K. Atiemo², K. Jackson³, A. Daud⁴, A. Kho³, J. Levitsky¹, D. P. Ladner⁴
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Transplant Surgery, Tulane, New Orleans, LA, ³Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University, Chicago, IL, ⁴Transplant Surgery, Northwestern University, Chicago, IL
*Purpose: The MELD-Na score widely used for medical decision making but is not a good predictor of patient outcomes at low scores. Although portal hypertensive…