Articles tagged "Liver transplantation"

2020 American Transplant Congress
Preclinical Study for Liver Allograft Tolerance after Rapid Immunosuppression Withdrawal Using Cynomolgus Monkeys
H. Sakai¹, E. Berglund¹, S. Chaudhry¹, Y. Kato¹, J. Weiner¹, P. Alonso-Guallart¹, N. Llore¹, K. Bruestle¹, F. Fredriksson¹, J. Stern¹, D. Ekanayake-Alper¹, M. Martinez², G. Pierre¹, M. Danton¹, S. Kofman¹, D. Ordanes¹, J. Lefkowitch³, A. Iuga¹, T. Kato⁴, M. Sykes¹, A. Griesemer¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Departments of Pathology and Cell Biology, Columbia University, New York, NY, ⁴Department of Surgery, Columbia University, New York, NY
*Purpose: Operational tolerance of liver allografts occurs in highly selected patients but cannot be reliably induced. Herein, we investigated if tolerance to liver can be…
2020 American Transplant Congress
Renal Function Parameters Improve PELDs Prediction of 90-day Death or Deterioration
L. Thalji¹, N. Thalji², D. Haile¹, J. Heimbach², S. Ibrahim³, P. Kamath⁴, D. Kor¹
¹Anesthesiology, Mayo Clinic, Rochester, MN, ²Surgery, Mayo Clinic, Rochester, MN, ³Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, ⁴Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: Reliance upon exception points to prioritize children for liver transplantation (LT) stems from concerns that the Pediatric End-Stage Liver Disease (PELD) score underestimates mortality.…
2020 American Transplant Congress
Evaluating the Efficacy of Robotic-Assisted Incisional Hernia Repair for Post-Liver Transplant Recipients
G. Rofaiel, G. Pan, M. Goodale, E. Martinez
University of Utah, Salt Lake City, UT
*Purpose: Hernia formation is a well-known complication following open abdominal surgery that contributes to post-operative morbidity and decreases in patient quality of life. Herein we…
2020 American Transplant Congress
Waiting List Mortality of Liver Tumors
V. G. Menon, Y. Chen, D. C. Chang, H. Yeh
Division of Transplantation, Massachusetts General Hospital, Boston, MA
*Purpose: Liver transplantation has been approved for hepatocellular carcinoma (HCC), hilar cholangiocarcinoma (CCA) and metastatic neuroendocrine tumors (NET), with the aim to produce similar outcomes…
2020 American Transplant Congress
Myosteatosis and its Impact on Graft- and Patient Survival in Adult Recipients of Deceased Donor Liver Transplantation
Z. Czigany, W. Kramp, G. van der Kroft, P. Strnad, M. Zimmermann, W. Liu, G. Wiltberger, U. Neumann, G. Lurje
University Hospital RWTH Aachen, Aachen, Germany
*Purpose: Recently our group demonstrated the role of myosteatosis in inferior perioperative outcomes (Czigany et al. Am J Transplant 2019) in recipients of orthotopic liver…
2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…
2020 American Transplant Congress
Treprostinil is Safe and Potentially Useful in Preventing Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients
R. Venkataramanan¹, I. H. Shaik², V. C. Pillai³, O. A. Almazroo⁴, M. K. Miah⁵, R. Xu², S. Dharmayan², A. Al-Khafaji², S. Ganesh², M. Molinari², A. Tevar², C. Hughes², A. Humar²
¹School Of Pharmacy, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³US Food and Drug Administration,, Silver Spring, MD, ⁴Saudi FDA, Riyadh, Saudi Arabia, ⁵Astra Zeneca, Boston, MA
*Purpose: Ischemia and reperfusion injury (IRI) is one of the unavoidable complications in orthotopic liver transplantion. Hepatic ischemic injury begins during the preservation of the…
2020 American Transplant Congress
Maternal Peripartum Complications in Solid Organ Transplantation
R. X. Wang¹, G. S. Lee-Riddle², D. O. Walls³, D. S. Goldberg⁴, P. L. Abt²
¹Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, ²Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³Department of Surgery, Robert Wood Johnson University Hospital, New Brunswick, NJ, ⁴Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
*Purpose: Previous studies examining pregnancy related complications after solid organ transplantation (SOT) primarily relied on voluntary registries and meta-analyses. Herein, we investigated maternal delivery outcomes…
2020 American Transplant Congress
Progression of Insulin Resistance after Liver Transplantation – Prospective Study
I. Mikova¹, D. Erhartova¹, K. Dvorakova¹, P. Sedivy², M. Drobny², M. Dezortova², M. Hajek², M. Cahová³, H. Dankova³, E. Sticova⁴, V. Lanska⁵, P. Trunecka¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ³Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Insulin resistance (IR) plays an important role in pathogenesis of nonalcoholic fatty liver disease (NAFLD) and other diseases. The data about prevalence and evolution…
2020 American Transplant Congress
Improvement of Renal Function Prior to Liver Transplantation is Not Associated with Better Long-Term Renal Outcome or Mortality
M. Sterneck¹, T. Horvatits², M. Touma², U. Herden³, A. Lohse², L. Fischer³
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: Since introduction of the MELD score in the liver allocation system, renal impairment in OLT recipients has become a topic of increasing importance. This…