Articles tagged "Liver transplantation"

2020 American Transplant Congress
Liver Plasmacytoid Dendritic Cells Express High Levels of DAP12, TREM2 and PD-L1 and Promote Effector T Cell Exhaustion and Augmented Treg Responses in Spontaneous Liver Transplant Tolerance
R. Nakano, O. Yoshida, S. Kimura, D. Geller, A. Thomson
University of Pittsburgh, Pittsburgh, PA
*Purpose: The precise mechanisms of liver transplant tolerance are yet to be elucidated. Non-conventional plasmacytoid dendritic cells (pDCs) are thought to promote immune regulation, including…
2020 American Transplant Congress
Inactive Status Changes Disproportionately Impacts the Probability of Obtaining a Deceased Donor Liver Transplant in Donation Service Areas with Higher MMaT
D. Haakinson¹, S. Noreen², D. Stewart², R. Batra¹, G. Gan¹, Y. Deng¹, S. Kulkarni¹
¹Yale, New Haven, CT, ²UNOS, Richmond, VA
*Purpose: Liver transplant (LT) rate is typically calculated by including both active and inactive patients, despite the fact that inactive patients are unable to receive…
2020 American Transplant Congress
Sleeve Gastrectomy Compared with Gastric Bypass for Morbidly Obese Liver Transplant Candidates: A Decision Analysis
R. A. Choudhury¹, D. Yoeli¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, J. J. Pomposelli¹, E. A. Pomfret¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: The use of bariatric surgery has increased for morbidly obese liver transplant candidates for whom placement on the waitlist is often restricted until they…
2020 American Transplant Congress
Evaluation of Tacrolimus Dose Requirement in Liver Transplant Recipients from African American Donors Compared to Non-African American Donors
K. Guilbert, I. Plasari, S. Wiehe, F. Gordon
Lahey Hospital and Medical Center, Burlington, MA
*Purpose: The purpose of this study is to evaluate whether a difference in tacrolimus total daily dose (TDD) exists between those receiving a liver transplant…
2020 American Transplant Congress
Impact of New Onset Atrial Fibrillation on Clinical Outcomes in Liver Transplant Recipients
C. M. Anugwom¹, S. Jackson², T. Pruett³, N. Lim¹
¹Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical Center, Minneapolis, MN, ²Fairview Health Services., Minneapolis, MN, ³Transplant Surgery, University of Minnesota Medical Center, Minneapolis, MN
*Purpose: Atrial fibrillation (AF) is a common arrhythmia in liver transplant (LT) recipients but there continues to be a paucity of data on this topic.…
2020 American Transplant Congress
Liver Transplant Waitlist Mortality is Not Associated with Urbanicity
Y. Chen¹, Y. Hung², Y. Hsu³, C. de Crescenzo¹, C. Rickert¹, J. Adler⁴, D. Chang¹, H. Yeh¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, Sinai Hospital of Baltimore, Baltimore, MA, ³Harvard School of Public Health, Boston, MA, ⁴Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Because of geographic disparity in transplant rates and organ usage, distance-based liver distribution has been proposed to replace Donor Service Area based distribution. However,…
2020 American Transplant Congress
Waitlist Mortality and Transplant Probability for Inactively Listed Liver Patients Depends on Donor Service Areas’ Median MELD at Transplant
R. Batra¹, S. Noreen², D. Stewart², D. Haakinson¹, G. Gan³, Y. Deng³, S. Kulkarni¹
¹Surgery, Yale University School of Medicine, New Haven, CT, ²UNOS, Richmond, VA, ³Yale University, New Haven, CT
*Purpose: Presently, the outcome of patients listed inactive on liver transplant waiting list (WL) are unknown; as inactive patients cannot receive deceased donor organ offers,…
2020 American Transplant Congress
Early Recurrence Of Hepatocellular Carcinoma Following Transplantation: Risk Score From A Multi-institutional Study Of > 3000 Patients
P. Tabrizian¹, M. Holzner², V. Agopian³, R. Busuttil³, G. Sapisochin⁴, N. Mehta⁵, F. Yao⁵, J. Roberts⁶, S. Florman¹, M. E. Schwartz¹, T. Ivanics⁷, J. Emond⁸, B. Samstein⁹, R. Brown, MD, MPH⁹, M. Najjar¹⁰, W. Chapman¹¹, M. Doyle¹¹, K. Halazun⁹
¹Transplant, Mount Sinai Medical Center, New York, NY, ²Surgery, Georgetown University Hospital, Washington DC, MD, ³Transplant, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Transplant, Univeristy of Toronto, Toronto, ON, Canada, ⁵Transplant, UCSF, San Francisco, CA, ⁶Transplantation, UCSF, San Francisco, CA, ⁷Transplant, University of Toronto, Toronto, ON, Canada, ⁸Transplant, Columbia University Medical Center, New York, NY, ⁹Transplant, Weill Cornell Medical Center, New York, NY, ¹⁰Transplant, Columbia Medical Center, New York, NY, ¹¹Transplant, Washington University School of Medicine, St Louis, MO
*Purpose: Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) carries a poor prognosis. We aimed to develop a risk score for early HCC…
2020 American Transplant Congress
Higher Probability of Living Donor Liver Transplantation is Associated with DSAs Having a Higher Median Meld at Transplant
D. Haakinson¹, S. Noreen², D. Stewart², R. Batra¹, G. Gan¹, Y. Deng¹, S. Kulkarni¹
¹Yale, New Haven, CT, ²UNOS, Richmond, VA
*Purpose: Recent studies show that outcomes of living donor liver transplantation (LDLT) are superior compared to those receiving deceased donor grafts. Access to deceased donor…
2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
K. J. Dery¹, K. Nakamura², K. Kadono¹, H. Hirao¹, S. Kageyama¹, T. Ito¹, H. Kojima¹, F. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, ²Surgery, Nishi-Kobe Medical Center, Hyogo, Japan
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…