Articles tagged "Liver transplantation"

2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, J. Aziz¹, X. Li², J. W. Kupiec-Weglinski¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
The Gut Microbiota Diversity and Metabolite Production is Reduced in Liver Transplant Recipients and Associated with Post-Operative Infection
C. J. Lehmann, R. Keskey, R. Nayak, E. Littmann, E. Pamer, T. Baker
University of Chicago, Chicago, IL
*Purpose: Liver transplant (LT) recipients have abnormal microbiota before and after transplantation. (1,2) The association between fecal microbiota, metabolites, and clinical outcomes in liver transplantation…
2021 American Transplant Congress
Transplant-free Survival in Alcohol-related Liver Disease (ALD) Patients Presenting with First Evidence of Ascites
K. Fahoum¹, N. T. Shen², E. Basu¹, J. Lee³, A. Kaplan², A. Salajegheh⁴, R. Rosenblatt², A. Jesudian², C. Lucero², B. Fortune², M. M. Safford⁵, R. S. Brown²
¹Medical College, Weill Cornell Medicine, New York, NY, ²Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, ³Population Health Sciences, Weill Cornell Medicine, New York, NY, ⁴Psychiatry, Weill Cornell Medicine, New York, NY, ⁵General Internal Medicine, Weill Cornell Medicine, New York, NY
*Purpose: The development of ascites is a poor prognostic sign for patients with cirrhosis. The factors associated with transplant-free survival at initial presentation with ascites…
2021 American Transplant Congress
Effects of TIPS on Transplant Outcomes for HCC
C. L. Hanlon¹, D. Toy¹, Y. Liu¹, S. Zhou¹, K. Zhou², J. Kahn², L. Yuan²
¹Internal Medicine, University of Southern California, Los Angeles, CA, ²Internal Medicine - Department of Gastroenterology and Hepatology, University of Southern California, Los Angeles, CA
*Purpose: The purpose of this study is to examine effects of TIPS placement on response to locoregional therapy (LRT) and clinical outcomes after liver transplantation…
2021 American Transplant Congress
Outcomes of DCD Allografts in Liver Transplant Recipients with HCC
N. Gupta¹, J. Daum¹, B. Aqel², L. Mi³, J. Harbell⁴
¹School of Medicine, Mayo Clinic Arizona, Phoenix, AZ, ²Hepatology, Mayo Clinic Arizona, Phoenix, AZ, ³Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, ⁴Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Early studies demonstrated inferior survival for liver transplant (LT) recipients with hepatocellular carcinoma (HCC) who received allografts from donation after cardiac death (DCD) donors…
2021 American Transplant Congress
Developmental Characteristics and Haemodynamics After Pediatric Donor to Adult Recipients in Liver Transplantation
M. Chen, L. Xiaohong, H. Xitao, C. Zhitao, J. W.
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: The developmental characteristics and hemodynamics of pediatric liver allografts transplanted into adult recipients remain unclear and deserve exploring.*Methods: Records from adult recipients undergoing liver…
2021 American Transplant Congress
Early Review of Liver Acuity Circles Allocation
S. Noreen¹, J. Heimbach², J. Pomposelli³, M. Cafarella¹, J. Trotter⁴
¹UNOS, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³UCHealth, Aurora, CO, ⁴BSWHealth, Dallas, TX
*Purpose: Acuity circles (AC) allocation was implemented on February 4, 2020, followed shortly by the declaration of national emergency for COVID-19. The goal of this…
2021 American Transplant Congress
The Evolution of the National Liver Review Board
S. Noreen¹, J. Trotter², J. Pomposelli³, M. Cafarella¹, J. Heimbach⁴
¹UNOS, Richmond, VA, ²BSWHealth, Dallas, TX, ³UCHealth, Aurora, CO, ⁴Mayo Clinic, Rochester, MN
*Purpose: The National Liver Review Board (NLRB) was implemented 5/14/2019, establishing a national structure for liver exceptions comprised of three specialty review boards and a…
2021 American Transplant Congress
Influence of Frailty on Psychometric Factors and Health-related Quality of Life in Patients on the Waitlist for Liver Transplantation
C. G. Klein, J. Latuske, E. Malamutmann, A. Paul, A. Oezcelik
University Medicine Essen, Essen, Germany
*Purpose: The aim of this prospective study was to evaluate the influence of frailty on depression, anxiety and health-related quality of life for patients on…