Articles tagged "Liver transplantation"

2021 American Transplant Congress
Dual Liver and Kidney Donors, What Makes Them Decide to Do It?
H. Al Harakeh, B. Emmanuel, C. Hughes, A. Tevar, J. Steel, A. F. DiMartini, S. Ganesh, A. Humar
Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: There is incongruity between the transplant waiting list and the number of deceased donors available, therefore there is an enduring challenge to increase the…
2021 American Transplant Congress
Outcomes of Liver Transplantation for Combined Hepatocellular Cholangiocarcinoma: A Single-center Experience
Y. Liu¹, C. Hanlon¹, S. Zhou¹, D. Toy¹, K. King², K. Zhou³, J. Kahn³, L. Yuan³
¹Internal Medicine, USC Keck School of Medicine, Los Angeles, CA, ²Radiology, USC Keck School of Medicine, Los Angeles, CA, ³Internal Medicine - Gastrointestinal and Liver Disease, USC Keck School of Medicine, Los Angeles, CA
*Purpose: Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a hepatic tumor that exhibits histological features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). cHCC-CCA is often diagnosed…
2021 American Transplant Congress
Liver Simulated Allocation Model Does Not Accurately Predict Organ Offer Decisions in Pediatric Liver Transplant Candidates
N. L. Wood¹, D. B. Mogul², E. K. Hsu³, E. R. Perito⁴, G. V. Mazariegos⁵, D. Vanderwerken¹, D. L. Segev², S. Gentry¹
¹US Naval Academy, Annapolis, MD, ²Johns Hopkins, Baltimore, MD, ³Univ of Washington, Seattle, WA, ⁴UCSF, San Francisco, CA, ⁵Univ of Pittsburgh, Pittsburgh, PA
*Purpose: The U.S. relies on the Scientific Registry of Transplant Recipient’s (SRTR’s) Liver Simulated Allocation Model (LSAM) to predict the effect of allocation policy changes…
2021 American Transplant Congress
The Utility of PET/ CT Testing in Cardiac Risk Stratification of Adult Liver Transplant Candidates
M. A. Tincopa¹, R. Weinberg¹, S. Sengupta¹, J. Slivnick², J. Corbett¹, C. Sonnenday¹, R. Fontana¹, P. Sharma¹
¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Ohio State University, Columbus, OH
*Purpose: Optimal cardiovascular (CV) risk stratification in liver transplant (LT) candidates remains unclear. The aim of this study was to assess concordance and utility of…
2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, J. Aziz¹, X. Li², J. W. Kupiec-Weglinski¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
The Gut Microbiota Diversity and Metabolite Production is Reduced in Liver Transplant Recipients and Associated with Post-Operative Infection
C. J. Lehmann, R. Keskey, R. Nayak, E. Littmann, E. Pamer, T. Baker
University of Chicago, Chicago, IL
*Purpose: Liver transplant (LT) recipients have abnormal microbiota before and after transplantation. (1,2) The association between fecal microbiota, metabolites, and clinical outcomes in liver transplantation…
2021 American Transplant Congress
Transplant-free Survival in Alcohol-related Liver Disease (ALD) Patients Presenting with First Evidence of Ascites
K. Fahoum¹, N. T. Shen², E. Basu¹, J. Lee³, A. Kaplan², A. Salajegheh⁴, R. Rosenblatt², A. Jesudian², C. Lucero², B. Fortune², M. M. Safford⁵, R. S. Brown²
¹Medical College, Weill Cornell Medicine, New York, NY, ²Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY, ³Population Health Sciences, Weill Cornell Medicine, New York, NY, ⁴Psychiatry, Weill Cornell Medicine, New York, NY, ⁵General Internal Medicine, Weill Cornell Medicine, New York, NY
*Purpose: The development of ascites is a poor prognostic sign for patients with cirrhosis. The factors associated with transplant-free survival at initial presentation with ascites…
2021 American Transplant Congress
Effects of TIPS on Transplant Outcomes for HCC
C. L. Hanlon¹, D. Toy¹, Y. Liu¹, S. Zhou¹, K. Zhou², J. Kahn², L. Yuan²
¹Internal Medicine, University of Southern California, Los Angeles, CA, ²Internal Medicine - Department of Gastroenterology and Hepatology, University of Southern California, Los Angeles, CA
*Purpose: The purpose of this study is to examine effects of TIPS placement on response to locoregional therapy (LRT) and clinical outcomes after liver transplantation…
2021 American Transplant Congress
Outcomes of DCD Allografts in Liver Transplant Recipients with HCC
N. Gupta¹, J. Daum¹, B. Aqel², L. Mi³, J. Harbell⁴
¹School of Medicine, Mayo Clinic Arizona, Phoenix, AZ, ²Hepatology, Mayo Clinic Arizona, Phoenix, AZ, ³Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, ⁴Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Early studies demonstrated inferior survival for liver transplant (LT) recipients with hepatocellular carcinoma (HCC) who received allografts from donation after cardiac death (DCD) donors…