Articles tagged "Liver transplantation"

2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, J. Aziz¹, X. Li², J. W. Kupiec-Weglinski¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
The Gut Microbiota Diversity and Metabolite Production is Reduced in Liver Transplant Recipients and Associated with Post-Operative Infection
C. J. Lehmann, R. Keskey, R. Nayak, E. Littmann, E. Pamer, T. Baker
University of Chicago, Chicago, IL
*Purpose: Liver transplant (LT) recipients have abnormal microbiota before and after transplantation. (1,2) The association between fecal microbiota, metabolites, and clinical outcomes in liver transplantation…
2021 American Transplant Congress
Obesity is a Risk Factor for Progression to Kidney Transplant Waitlisting After Liver Transplantation
B. Shelton¹, B. Orandi¹, K. Olthoff², E. Pomfret³, K. Forde², D. Sawinski², M. Gray¹, N. Ascher⁴, J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Pennsylvania, Philadelphia, PA, ³University of Colorado School of Medicine, Aurora, CO, ⁴University of California San Francisco, San Francisco, CA
*Purpose: Non-alcoholic steatohepatitis (NASH) has emerged as a leading cause of cirrhosis, and obesity-associated comorbid conditions, including renal disease have become more prevalent. Obesity predisposes…
2021 American Transplant Congress
Liver Transplant in Adult Recipients Using Pediatric Deceased Donor Liver Grafts
P. Vargas¹, C. Argo², H. Zachary², M. Stotts², N. Intagliata², P. Northup², S. Pelletier¹, J. Oberholzer¹, N. Goldaracena¹
¹Transplant surgery, University of Virginia, Charlottesville, VA, ²Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA
*Purpose: The aim of this study is to evaluate the outcomes following liver transplantation (LT) in adults using grafts from a pediatric deceased donor.*Methods: A…
2021 American Transplant Congress
Short Waiting Time is Not Associated with Decrease in Disease-free Survival in Liver Transplant Recipients with HCC
J. Daum¹, N. Gupta¹, B. Aqel², L. Mi³, J. Harbell⁴
¹School of Medicine, Mayo Clinic Arizona, Phoenix, AZ, ²Hepatology, Mayo Clinic Arizona, Phoenix, AZ, ³Biostatistics, Mayo Clinic Arizona, Phoenix, AZ, ⁴Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Studies have suggested that shorter waiting times (WT) for liver transplant (LT) in patients with hepatocellular carcinoma (HCC) may be associated with increased HCC…
2021 American Transplant Congress
Assessing the Impact of the New Liver Allocation Policy on Transplant Center and Organ Procurement Organization Logistics
W. P. Sawyer¹, A. Gracon²
¹General Surgery, Ochsner Health System, New Orleans, LA, ²Transplant Surgery, Ochsner Health System, New Orleans, LA
*Purpose: In February 2020, a new policy for liver allocation was instituted in an effort to reduce geographic disparity in median MELD at transplant. To…
2021 American Transplant Congress
Early Review of Liver Acuity Circles Allocation
S. Noreen¹, J. Heimbach², J. Pomposelli³, M. Cafarella¹, J. Trotter⁴
¹UNOS, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³UCHealth, Aurora, CO, ⁴BSWHealth, Dallas, TX
*Purpose: Acuity circles (AC) allocation was implemented on February 4, 2020, followed shortly by the declaration of national emergency for COVID-19. The goal of this…
2021 American Transplant Congress
The Evolution of the National Liver Review Board
S. Noreen¹, J. Trotter², J. Pomposelli³, M. Cafarella¹, J. Heimbach⁴
¹UNOS, Richmond, VA, ²BSWHealth, Dallas, TX, ³UCHealth, Aurora, CO, ⁴Mayo Clinic, Rochester, MN
*Purpose: The National Liver Review Board (NLRB) was implemented 5/14/2019, establishing a national structure for liver exceptions comprised of three specialty review boards and a…
2021 American Transplant Congress
Influence of Frailty on Psychometric Factors and Health-related Quality of Life in Patients on the Waitlist for Liver Transplantation
C. G. Klein, J. Latuske, E. Malamutmann, A. Paul, A. Oezcelik
University Medicine Essen, Essen, Germany
*Purpose: The aim of this prospective study was to evaluate the influence of frailty on depression, anxiety and health-related quality of life for patients on…