Articles tagged "Liver transplantation"

2022 American Transplant Congress
Analysis of Hepatic Graft Survival in Extended Criteria Donors: Systematic Review and Meta-Analysis of Comparative Studies
M. M. Pascale¹, F. Frongillo¹, G. Bianco¹, I. Neri¹, G. Dalla Riva², M. Reale², S. Agnes¹, F. Giovinazzo¹
¹General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, ²University of Canterbury, Canterbury, New Zealand
*Purpose: Extended Criteria Donors include several definitions. These criteria vary across transplant centers and often rely on the center policy. The present meta-analysis analyzed graft…
2022 American Transplant Congress
130 Totally Robotic Donor Hepatectomy: Reproducibility Of A Standardized Technique Across 2 Specialized Centers
Y. Cheah¹, H. Yang², C. J. Simon¹, J. Kim³, M. Akoad³, G. Choi²
¹Roger L Jenkins Transplant Institute, Lahey Hospital & Medical Center, Burlington, MA, ²Division of HPB Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Lahey Hospital & Medical Center, Burlington, MA
*Purpose: Robotic surgery is emerging as a feasible though complex technique to enable minimally-invasive donor hepatectomy.*Methods: First multicenter prospective study on 130 consecutive totally robotic…
2022 American Transplant Congress
An Interim Report on a Prospective Randomized Trial of Extended-Release Tacrolimus in Liver Transplantation with Anti-Thymocyte Induction in a Steroid Free Protocol
R. A. Helmick, S. Naik, C. Eymard, J. Eason, J. Vanatta
James D. Eason Transplant Institute at Methodist University Hospital and University of Tennessee Health Science Center, Memphis, TN
*Purpose: Our study hypothesis was that once daily dosing of extended-release tacrolimus (ERT) would be a safe and effective immunosuppression (IS) with the potential to…
2022 American Transplant Congress
Prediction of Waitlist Mortality in Liver Transplant Candidates: Do Time-Varying Models Help?
A. Kwong¹, W. Kim¹, D. Schladt², A. Wey², J. Snyder², A. Israni², J. Lake³
¹Stanford University, Stanford, CA, ²Hennepin Healthcare Research Institute, Minneapolis, MN, ³University of Minnesota, Minneapolis, MN
*Purpose: In the United States, priority on the liver transplant waitlist is determined by the model for end-stage liver disease (MELD)-Na, a score composed of…
2022 American Transplant Congress
Long-Term Implication of Kidney Injury Prior to Liver Transplantation for Acute Liver Failure
M. R. Cloonan¹, D. J. Cloonan², S. Westphal³, L. A. Dageforde¹, S. Merani¹
¹Division of Transplant, Department of Surgery, University of Nebraska Medical Center, Omaha, NE, ²Division of Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Acute liver failure (ALF) is a heterogeneous disease process that often includes acute kidney injury. Long-term sequelae of kidney impairment in patients with ALF…
2022 American Transplant Congress
Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients
K. Deng¹, N. Tanimine², C. Breeden³, B. Burrell³, G. Gaile³, K. Lee¹, R. Matheson¹, F. Qiang¹, C. Rickert¹, C. LeGuern¹, J. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, ³Immune Tolerance Network, Bethesda, MD
*Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
A. S. Kurt¹, P. Ruiz¹, E. Kodela¹, G. Lombardi¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…
2022 American Transplant Congress
The Limited Role of Liver Transplantation in Porto-Pulmonary Hypertension Pathology
J. Doi¹, M. Fujiki², S. Chaudhry¹, T. Diago¹, F. Aucejo¹, C. Kwon¹, B. Eghtesad³, C. Miller⁴, C. Quintini⁵, K. Hashimoto¹
¹Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH, ³The Cleveland Clinic, Cleveland, OH, ⁴The Cleveland Clinic, Bratenahl, OH, ⁵Cleveland Clinic, Beachwood, OH
*Purpose: Portopulmonary hypertension (POPH) refers to pulmonary artery hypertension (PH) as a consequence of portal hypertension with or without liver disease. Previous studies used pulmonary…
2022 American Transplant Congress
Covid-related Neonatal Cholestasis?: Liver Transplantation In Three Infants With Intrauterine Or Perinatal Covid Exposure
S. Sakhuja¹, K. Patel¹, N. T. Galvan²
¹Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Houston, TX
*Purpose: The COVID pandemic presents a unique set of challenges during pregnancy including thromboembolic complications, direct placental infection, transplacental transmission, and systemic hyperinflammatory state. The…
2022 American Transplant Congress
T Cell-Specific CEACAM1 Alleviates Posttransplant Liver Injury via TIM-3 Inhibitory Regulation
H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski
UCLA Medical Center, Los Angeles, CA
*Purpose: Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1; CC1), a recently discovered ligand for T cell immunoglobulin domain and mucin domain-3 (TIM-3) on activated T…