Articles tagged "Liver transplantation"

2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
R. Sindhi¹, X. Shao², C. Ashokkumar¹, T. Pastinen³, R. Sindhi⁴
¹Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²National Research Council Canada, Digital Technologies Research Centre, National Research Council Canada, Ottawa, ON, Canada, ³University of Missouri-Kansas City School of Medicine, Kansas City, MO, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…
2022 American Transplant Congress
Temporal Trends of Optn Hope Act Variance Participation
A. Wilk¹, M. Green², C. Marsh³, N. Theodoropoulos⁴, R. Formica⁵, N. Turgeon⁶, A. Fox⁷, A. Wilhelm¹, D. Klassen¹
¹UNOS, Richmond, VA, ²UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Scripps Clinic & Scripps Green Hospital, La Jolla, CA, ⁴UMass Medical, Worcester, MA, ⁵Yale, New Haven, CT, ⁶UT Health Austin, Austin, TX, ⁷CUIMC/Presbyterian Hospital, New York, NY
*Purpose: The Organ Procurement and Transplantation Network (OPTN) created a research variance allowing for transplantation of HIV+ donor kidneys and livers into HIV+ recipients after…
2022 American Transplant Congress
Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro⁵, J. Pawlowska¹⁰, R. Mikolajczyk¹¹, U. Baumann¹², C. Falk¹³
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹¹German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹²Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, ¹³Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
2022 American Transplant Congress
Heterogeneity in Center Practices in Liver Transplantation for Alcohol-Associated Liver Disease in the United States
N. Lim¹, A. Kwong², S. Jafri³, M. Jesse³, M. Kriss⁴, K. Nair⁵, A. Pillai⁶, A. Shingina⁷, A. Desai⁸
¹Division of Gastroenterology, Hepatology & Nutrition, University of Minnesota, Minneapolis, MN, ²Stanford University, Palo Alto, CA, ³Henry Ford Hospital, Detroit, MI, ⁴University of Colorado School of Medicine, Aurora, CO, ⁵Community Health Network, Indianapolis, IN, ⁶University of Chicago, Chicago, IL, ⁷Vanderbilt University, Nashville, TN, ⁸Indiana University, Indianapolis, IN
*Purpose: Alcohol-associated liver disease (ALD) is now the leading indication for liver transplantation (LT) in the United States (US), particularly since LT has emerged as…
2022 American Transplant Congress
Characterization of ICU Delirium Among Liver Transplant Recipients
J. M. Ruck, K. Neufeld, E. Oh, J. C. Lai, E. King
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delirium has been shown to impact the hospital courses of older adults. Liver transplant (LT) recipients are a population that has previously been identified…
2022 American Transplant Congress
The Gift of Life: Gift Discourse in Transplant and Its Implications in Anonymous Living Liver Donation
S. S. Humar¹, J. Jung², S. Krause¹, N. Selzner¹, S. Abbey¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: The Gift of Life metaphor is prevalent in pro-donation dialogue, aiming to promote transplant programs and conceptualize the act of organ donation. To obtain…
2022 American Transplant Congress
Baseline Levels and Early Post-Transplant Kinetics of Donor-Derived Cell-Free DNA Following Liver Transplantation
S. Florman¹, D. Axelrod², J. Miles³, E. Vaskova³, D. Kilam³, K. Dhanireddy⁴, V. Subramanian⁴
¹Mount Sinai Medical Center, New York, NY, ²University of Iowa, Iowa City, IA, ³CareDx, South San Francisco, CA, ⁴Tampa General Hospital, Tampa, FL
*Purpose: Non-invasive biomarkers in liver transplant (LT) are needed to improve detection of allograft injury in routine surveillance and during immunosuppression modulation, prior to the…
2022 American Transplant Congress
Impact of Graft Type, Presence and Type of Inflammatory Bowel Disease on Outcomes Following Liver Transplantation for Primary Sclerosing Cholangitis
S. Kumar¹, S. Lin², J. D. Schold³
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Center for Populations Health Research, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: In Primary sclerosing cholangitis (PSC), concerns exist regarding outcomes following donation after circulatory death (DCD) liver transplantation (LT) due to risk of ischemic cholangiopathy…
2022 American Transplant Congress
Team Decision-Making in Liver Transplant Evaluation: A Multi-Center Ethnographic Observation Study
C. N. Sidoti, H. C. Sung, D. L. Segev, M. L. Levan, T. S. Purnell, A. T. Strauss
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Transplant providers are tasked with making ethically complex and high-stakes decisions of determining a patient’s candidacy for liver transplantation within a multi-disciplinary team. We…
2022 American Transplant Congress
Waitlist Meldna Variation One-year Prior To Liver Transplant Predicts Length Of Stay At The Time Of Transplant
L. Pruinelli¹, S. Olson¹, J. Zhou¹, M. Nguyen¹, J. Schold², T. Pruett¹, S. Ma¹, G. Simon¹
¹University of Minnesota, Minneapolis, MN, ²Cleveland Clinic Foundation, Cleveland, OH
*Purpose: MELDNa is used to estimate 90-day mortality in the waitlist. MELDNa variation between cross-sections has shown a better predictivity than when analyzed as a…