Articles tagged "Liver transplantation"

2022 American Transplant Congress
18 Month Impact of the National Liver Review Board
J. Foutz¹, S. Noreen¹, K. Bradbrook², M. Cafarella¹, J. Pomposelli³, S. Biggins⁴, J. Trotter⁵
¹United Network for Organ Sharing, Richmond, VA, ²Research, United Network for Organ Sharing, Richmond, VA, ³University of Colorado, Aurora, CO, ⁴University of Washington, Seattle, WA, ⁵Baylor University Medical Center, Dallas, TX
*Purpose: The National Liver Review Board (NLRB) was implemented 5/14/2019, establishing a national structure for liver exceptions comprised of three specialty review boards and a…
2022 American Transplant Congress
Fibrin Deposition in Ischemic Damaged Liver Grafts and Reconditioning with Thrombolytic Therapy During Normothermic Machine Perfusion
T. Goto, Y. Noguchi, S. Ganesh, B. Arulratnam, M. Kawamura, C. Parmentier, S. Ray, T. Reichman, N. Selzner, M. Selzner
Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada
*Purpose: Normothermic ex situ perfusion (NMP) is a novel technique for the storage and assessment of marginal livers retrieved from donors after circulatory death (DCD).…
2022 American Transplant Congress
Liver Transplantation for Combined Hepatocellular-Cholangiocarcinoma: An Analysis of the European Liver Transplant Registry
M. P. Claasen¹, T. Ivanics², J. N. IJzermans¹, G. Sapisochin², W. Polak¹
¹HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands, ²Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Little is known about combined hepatocellular-cholangiocarcinoma (cHCC-CCA) demographics and their long-term outcomes after liver transplantation (LT). By analysing data from the European Liver Transplant…
2022 American Transplant Congress
Regional Variation in Early Effects of Acuity Circle-Based Liver Allocation
T. Ivanics¹, S. Nagai², T. Kitajima², S. Shimada², T. Shamaa², K. Collins², M. Rizzari², A. Yoshida², D. Moonka², M. Abouljoud²
¹University of Toronto - University Health Network, Toronto, ON, Canada, ²Henry Ford Hospital, Detroit, MI
*Purpose: Liver allocation in the United States was updated on February 4th, 2020, byintroducing the acuity circle (AC)-based model. This study evaluated the early effects…
2022 American Transplant Congress
Influence of Immunosuppressive Drugs on Nk Cells in Therapeutic Drug Exposured
R. r. Qin¹, C. Sun², B. Nashan¹
¹Division of Life and Medicine, University of Science and Technology of China/The First affiliated hospital of University of Science and Technology of China, Hefei, China, ²Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose:Natural killer (NK) cells as part of the innate immune system are residing in the liver and are considered to be main regulators in alloimmune…
2022 American Transplant Congress
Cost-Effective and Time-Saving Three-Dimensional (3-D) Printing Protocol of Intra-Abdominal Cavity of Liver Transplantation Recipient to Prevent Large-for-Size Syndrome
S. Park, G. Choi, J. Kim, S. Lee, J. Joh, J. Rhu
General Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: The application of Three-dimensional (3-D) printing has been increasing and we invented a protocol for a cost-effective and time-saving 3-D model of intra-abdominal cavity…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
R. Nakano, A. Perez Gutierrez, G. Camirand, D. A. Geller, A. W. Thomson
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…
2022 American Transplant Congress
Safety and Immunogenicity of BNT-162b2 versus Chadox1 Vaccine in Solid Organ Transplant Recipients: Prospective Study
A. Ajlan¹, T. Ali², H. Aleid², K. Almeshari², M. Alkaff³, S. Althuwaidi⁴, L. Fajji², A. Alali⁵, D. Halabi⁶, A. Ullah⁷, K. H. Marquez⁸, B. Elmikkaoui⁹, A. Alrajhi¹⁰, A. Zidan¹¹, E. Albogumi.¹², K. Bzeizi¹³, R. Almaghrabi¹⁴, E. DeVol¹⁵, M. Al-Awwami,¹⁶, S. Alghamdi¹³, P. Broering²
¹Pharmaceutical Care Division - Organ Transplant Centre of Excellence, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riaydh, Saudi Arabia, ²Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ³Medical Laboratory, KFSHRC, Riaydh, Saudi Arabia, ⁴Medical Microbiology, KFSHRC, Riaydh, Saudi Arabia, ⁵Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁶Transplant Coordination Team - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁷Kidney & Pancreas Health Centre, KFSHRC, Riaydh, Saudi Arabia, ⁸Analytics Data Centre - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ⁹Data Management - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁰Infectious Diseases - Medicine Department, KFSHRC, Riaydh, Saudi Arabia, ¹¹Abdominal Transplant & Hepatobiliary Surgery Centre, KFSHRC, Riaydh, Saudi Arabia, ¹²Data Management. - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹³Liver & Small Bowel Health Centre, KFSHRC, Riaydh, Saudi Arabia, ¹⁴Infectious Diseases - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia, ¹⁵Biostatistics, Epidemiology &Scientific Computing, KFSHRC, Riaydh, Saudi Arabia, ¹⁶Histocompatibility and Immunogenetics Laboratory Kidney & Pa - Organ Transplant Centre of Excellence, KFSHRC, Riaydh, Saudi Arabia
*Purpose: Data showed seroconversion after different SARS-CoV-2 vaccination platforms might yield diminished response in transplant recipients. However, it is unknown whether different vaccination platforms could…
2022 American Transplant Congress
Liver Transplant Recipient Gender and Race: Impact on Clinical Outcomes
M. M. French¹, R. Mangus¹, R. Holmes¹, A. Krause¹, J. Sumner¹, C. Kubal², B. Ekser³, P. Mihaylov⁴, J. Fridell⁵, A. Lutz⁶
¹Department of Surgery, Indiana University, Indianapolis, IN, ²Department of Surgery, Indiana University Hospital, Indianapolis, IN, ³Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ⁴Department of Surgery, Indiana Univ School of Medicine, Indianapolis, IN, ⁵Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, ⁶Indiana University, Fishers, IN
*Purpose: Background. Health disparities are present in transplantation. This is a retrospective review of liver transplant (LT) recipients determining the impact of race/gender on early…