Articles tagged "Liver transplantation"

2015 American Transplant Congress
Significant Reduction in TRAIL-Expressing NK Cells in Remnant Liver After Partial Hepatectomy Is Strongly Associated With the Impaired Intrahepatic CXCL9–CXCR3 Pathway
T. Yano, M. Ohira, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima City, Japan.
Antitumor activity of liver natural killer (NK) cells decreases after partial hepatectomy or liver transplantation (LT), suggesting the susceptibility of patients with depressed immune status…
2015 American Transplant Congress
Controlled Hemodilution in Infant Liver Transplants: A Single Center Experience
T. Todo,¹ A. Gallo,¹ J. Mendoza,² T. Pham,¹ C. Esquivel.¹
¹Dept of Surgery, Stanford University, Palo Alto, CA; ²Dept of Anesthesia, Stanford University, Palo Alto, CA.
Introduction: Hepatic artery thrombosis (HAT) remains a major comorbidity in pediatric liver transplants often resulting in graft loss and mortality. Controlled hemodilution decreases blood viscosity…
2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
M. Morita, D. Joyce, C. Miller, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…
2015 American Transplant Congress
Real-Time Measurements of Tissue Oxygen Microtension as a Marker of Bile Duct Viability in Liver Transplantation
R. Ciria-bru, E. Navarro-Rodriguez, M. Sanchez-Frías, J. Medina-Fernandez, A. Gallardo-Herrera, M. Ayllon-Teran, S. Rufián-Peña, P. Lopez-Cillero, J. Briceño-Delgado.
General Surgery, HU Reina Sofía, Córdoba, Spain.
Aims: To evaluate bile duct viability by assessing its microvascular quality using an innovative real-time oxygen tension device by testing different areas in both donor…
2015 American Transplant Congress
Impact of Anatomic Variation and Reconstructive Technique on Complications Following Living Liver Donor Transplantation – A Report from the A2ALL Consortium
T. Baker,¹ M. Zimmerman,² B. Samstein,³ E. Pomfret,⁴ J. Pomposelli,⁴ C. Berg,⁵ N. Goodrich,⁶ B. Gillespie,⁷ J. Emond.³
¹Northwestern University, Chicago; ²University of Colorado, Denver; ³Columbia University, New York; ⁴Lahey Clinic, Burlington; ⁵Duke University, Durham; ⁶Arbor Research, Ann Arbor; ⁷University of Michigan, Ann Arbor.
Introduction: Living donor liver transplantation [LDLT] is a technically demanding endeavor that requires command of the complex anatomy of partial liver grafts. The aim of…
2015 American Transplant Congress
Combined Hepatitic/Cholangiopathic Lesion in HIV-HCV Co-Infected Liver Transplant Recipients Associated With Graft Loss
J. Harbell,¹ A. Doherty,² L. Ferrell,² B. Barin,³ N. Terrault,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Pathology, University of California, San Francisco, San Francisco, CA; ³EMMES Corporation, Rockville, MD.
Background: Co-infection with HIV and viral hepatitis results in poorer outcomes following liver transplantation. In this population, complex immune status, extensive drug regimens, and comorbid…
2015 American Transplant Congress
Effects of Early Everolimus Use for Immunosuppression in Living Donor Liver Transplant Recipients- An Analysis of 215 Sequential Patients
A. Thorat, Y.-W. Hsieh, H.-R. Yang, C.-C. Yeh, T.-H. Chen, S.-C. Hsu, L.-B. Jeng.
Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan.
Purpose:In our previously published study, we concluded the safety of everolimus (EVR) in early stage after living donor liver transplantation (LDLT). In this large scale…
2015 American Transplant Congress
Increased Risk of VRE Infection in Liver Transplant Patients With MELD of 35 or Greater
A. Nelson,¹ R. Girlanda.²
¹Department of Pharmacy, Medstar Georgetown University Hospital, Washington, DC; ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Vancomycin Resistant Enterococcus (VRE) infection is recognized as a cause of morbidity in liver transplant patients. In the wake of Share 35, sick patients receiving…
2015 American Transplant Congress
Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection
S. Shimizu, Y. Tanaka, H. Tazawa, S. Verma, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…
2015 American Transplant Congress
The Impact of Ischemia/Reperfusion Injury On Liver Allografts from Deceased After Cardiac Death Versus Deceased After Brain Death Donors
B. Sayed, J. Xu, A. Casas-Ferreira, P. Srinivasan, N. Heaton, Y. Ma, C. Legido-Quigley, S. Fuggle, W. Jassem.
1Liver Transplant Unit, Institute of Liver Studies, King's College Hospital, London, United Kingdom; Department of Transplant Surgery, Emory University, Atlanta, United Kingdom; Institute of Pharmaceutical Science, King's College Hospital, London, United Kingdom; Department of Analytical Chemistry, University of Salamanca, Salamanca, Spain; Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom.
Background and Aims:The shortage of appropriate organs for transplantation has led to the use of organs from donors after cardiac death. The pathophysiologic processes associated…