ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Liver transplantation"

  • 2015 American Transplant Congress

    Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients

    J. Nolte,1 S. Gordon Burroughs,1 D. Victor,1 C. Mobley,1 N. Yu,2 T. Hirase,1 A. Saharia,1 A. Rajaraman,1 L. Moore,1 A. Gaber,1 R. Ghobrial.1

    1Surgery, Houston Methodist Hospital, Houston, TX; 2Radiology, Houston Methodist Hospital, Houston, TX.

    Introduction: Calculations used to determine expected survival post-liver transplant (OLT) are in part based on pre-OLT functional status. Functional status is subjectively measured by Karnofsky…
  • 2015 American Transplant Congress

    Validation of the Model for End-Stage Liver Disease Score Criteria in Liver Transplantation for Acute Flare Up of Hepatitis B in Non-Cirrhotic Liver

    W.-C. Lee,1 T.-J. Wu,1 C.-F. Lee,1 R.-S. Soong,1 C.-H. Cheng,1 H.-S. Chou,1 T.-H. Wu,1 K.-M. Chan,1 Y.-C. Wang,1 C.-S. Lee.2

    1Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan; 2Hepatology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

    Background: Decision of necessity of urgent liver transplantation for acute flare up of hepatitis B in the patients without cirrhosis is difficult. The MELD score…
  • 2015 American Transplant Congress

    Bridging Therapy With Belatacept in High MELD Liver Transplant Recipients

    T. Sparkes,1 B. Masters,1 S. Hanish,2 D. Potosky,2 W. Hutson,2 J. LaMattina,2 R. Barth.2

    1University of Maryland Medical Center, Baltimore; 2University of Maryland School of Medicine, Baltimore.

    Background: Poor outcomes of high-MELD liver transplant recipients are driven by multisystem organ dysfunction. Renal failure post-transplant has been associated with mortality of greater than…
  • 2015 American Transplant Congress

    Pre-Transplant Portal Vein Recanalization-Transjugular Intrahepatic Portosystemic Shunt in Patients With Chronic Portal Vein Thrombosis

    B. Thornburg, K. Desai, T. Baker, J. Fryer, M. Abecassis, J. Caicedo, L. Kulik, R. Salem.

    Northwestern Memorial Hospital, Chicago, IL.

    Background: Chronic, occlusive portal vein thrombosis (PVT) associated with cirrhosis represents a relative contraindication to liver transplantation (LT) in some centers. From a surgical perspective,…
  • 2015 American Transplant Congress

    Incidence and Impact of De Novo Donor-Specific Anti-HLA Antibodies in ABO-Compatible Liver-Transplant Recipients

    A. Del Bello,1,2 N. Congy-Jolivet,2,3,4 D. Milongo,1 C. Guilbeau-Frugier,2,5 L. Lavayssière,1 F. Muscari,2,6 L. Rostaing,1,2,7 N. Kamar.1,2,7

    1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; 2Université Paul Sabatier, Faculté de Médecine, Toulouse, France; 3Molecular Immunogenetics Laboratory, EA 3034, Faculté de Médecine Purpan, IFR150, Toulouse, France; 4Department of Immunology, CHU Rangueil, Toulouse, France; 5Department of Pathology, CHU Rangueil, Toulouse, France; 6Surgery and Liver Transplantation, CHU Rangueil, Toulouse, France; 7INSERM U1043, IFR–BMT, CHU Purpan, Toulouse, France.

    Background: The incidence and consequences of de novo donor-specific anti-HLA antibodies (DSAs) after liver transplantation (LT) are not well known. Thus, we investigated the incidence,…
  • 2015 American Transplant Congress

    HO-1 Modified Macrophages Promote Autophagy by Activating Sirt1/TGF-β/Smad4 Signaling in Ischemia-Stressed Mouse Liver Transplants

    S. Yue, J. Huang, K. Nakamura, M. Zhou, X.-D. Shen, R. Busuttil, B. Ke, J. Kupiec-Weglinski.

    Dumont-UCLA Transplant Ctr, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.

    Background: Although heme oxygenase-1 (HO-1) is known to induce alternative macrophage activation towards an anti-inflammatory M2 phenotype, the underlying mechanisms remain elusive. Autophagy may play…
  • 2015 American Transplant Congress

    Biliary Complication After Living Donor Liver Transplantation According to Biliary Reconstruction Methods

    J. Lee,1,2 J. Lee,1,2 D. Han,1,2 J. Lee,3 M. Ju,1,2 M. Kim,1,2 G. Choi,1,2 J. Choi,1,2 S. Kim,1,2 D. Joo.1,2

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Bundang, Korea.

    BackgroundDespite improvement of operative techniques and long term outcomes, biliary complication remains as a severe obstacle in living donor liver transplantation.MethodsMedical records of 245 adult…
  • 2015 American Transplant Congress

    Racial Disparities in Living Donor Liver Transplantation

    Y. Nobel,1 K. Forde,2 L. Wood,3 P. Yoo,4 P. Abt,3 D. Goldberg.2

    1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; 2Department of Medicine, University of Pennsylvania, Philadelphia, PA; 3Division of Transplant Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA; 4Department of Surgery, Yale University School of Medicine, New Haven, CT.

    Purpose: Living donor liver transplantation (LDLT) is an alternative to deceased donor transplantation (DDLT), and can mitigate the risk of dying while waiting for transplant.…
  • 2015 American Transplant Congress

    Preventing Cytomegalovirus Infection in Intermediate-High Risk Liver Transplant Recipients: Acyclovir Vs Valganciclovir

    S. Dulanya, A. Anamisis, D. Tsapepas.

    Department of Pharmacy, New York Presbyterian Hospital, New York City, NY.

    Cytomegalovirus (CMV) is an opportunistic infection responsible for profound morbidity and mortality among solid organ transplant recipients. A donor and recipient's CMV IgG serostatus influences…
  • 2015 American Transplant Congress

    An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation

    C. Falk,1 I. Goldschmidt,2 F. Mutschler,2 C. Neudörfl,1 J. Keil,1 K. Daemen,1 F. Lehner,3 R. Mikolajzcyk,4 A. Karch,4 U. Baumann.2

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; 3Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; 4Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.

    The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
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