2015 American Transplant Congress
Are We Missing Cardiovascular Disease in Children Awaiting Liver Transplant?
Background: Cirrhotic cardiomyopathy, characterized by low systemic vascular resistance, is increasingly recognized as a complication of end stage liver disease. Yet optimal strategies to screen…2015 American Transplant Congress
Pediatric Liver Transplantation for Metabolic Diseases: Analysis of Children's Hospital of Pittsburgh (CHP) and United Network for Organ Sharing (UNOS) Databases
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Purpose: To analyze long term patient survival outcomes after primary LTx for metabolic disease in children <21 years at CHP (1981-2014) and the multi-center UNOS…2015 American Transplant Congress
Iron Deficiency Impairs Regulatory T Cell Induction
In a recent clinical trial of immunosuppression withdrawal in adult liver transplant recipients, operational tolerance was associated with development of a transient lymphocyte infiltration rich…2015 American Transplant Congress
Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush
Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…2015 American Transplant Congress
Impact of Pretransplant Sarcopenia and Sequential Changes in Sarcopenic Parameters After Living Donor Liver Transplantation
The present study investigated the impact of pretransplant sarcopenia on survival and sequential changes in sarcopenic parameters in patients undergoing living donor liver transplantation (LDLT).…2015 American Transplant Congress
HCV Treatment in Liver Transplantation: Changes in Center Attitudes and Practices in the DAA Era
Surgery, Johns Hopkins University, Baltimore, MD.
Chronic hepatitis C virus infection (HCV) is the leading indication for liver transplantation (LT) in the US. Safe and effective directly acting antivirals (DAAs) are…2015 American Transplant Congress
Hepatic T Cells Derived from Normothemic Machine Perfused Grafts Contained More Regulatory T Cells and Fewer Proinflammatory Cytokines Producing T Cells Than Those from Cold Storage Grafts
Background & aim:In liver transplantation, ischemia reperfusion (I/R) injury is associated with an inflammatory response affecting graft and patient outcomes. Ex-vivo normothermic machine perfusion (NMP)…2015 American Transplant Congress
Liver Flushing Using Colloid and Crystalloid Solutions
Abdominal Organ Transplantation, Oregon Health and Science University, Portland.
Background:Preservation solutions such as University of Wisconsin solution and histidine-tryptophan-ketoglutarate solution have been cited as causes of hypotension and adverse donor reactions following reperfusion of…2015 American Transplant Congress
Liver Fabrication Using Whole Organ Scaffold for Transplantable Graft in Large Animal
Background and aims: Orthotopic liver transplantation is only effective treatment for end-stage liver disease, however it is limited by shortage of donor livers. Therefore, novel…2015 American Transplant Congress
Nonalcoholic Steatohepatitis as Indication for Liver Transplantation in Europe. Do We Choose the Right Organs for the Right Recipients?
Background:Nonalcoholic steatohepatitis (NASH) has emerged to become the third leading cause for liver transplantation (LT) in the US and since 2002, it has increased constantly.Methods:We…
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