Articles tagged "Liver transplantation"

2016 American Transplant Congress
Pre-Mortem Cannulation and NECMO Preservation for DCD Liver Transplantation.
P. Ruiz,¹ M. Gastaca,¹ A. Valdivieso,¹ A. Ventoso,¹ I. Palomares,¹ M. Prieto,¹ J. Bustamante,² P. Salvador,² J. Ortiz de Urbina.¹
¹Liver Surgery and Liver Transplant Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain; ²Hepatology and Liver Transplant Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain.
Introduction: Herein, we present the short-term results of a controlled DCD liver transplantation program with pre-mortem cannulation and normothermic extracorporeal membrane oxygenation (NECMO) preservation.Material and…
2016 American Transplant Congress
Protective Effects of Nrf2 Over-Activation in Myeloid Cells During Hepatic Ischemia Reperfusion Correlates with Stat3 Signaling in Hepatocytes.
C. Harberg,¹ L.-Y. Lee,¹ S. Werner,² D. Johnson,³ J. Johnson,³ D. Foley.¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland; ³Pharmaceutical Sciences, University of Wisconsin School of Pharmacy, Madison, WI.
Ischemia-reperfusion injury (IRI) is a consequence of liver resection and liver transplantation. The Nrf2-antioxidant response element pathway is a key mediator of cellular defense against…
2016 American Transplant Congress
The Use of Perioperative Lactate Values as Markers for Adverse Outcomes in Liver Transplantation.
B. Rao,¹ A. Yoshida,³ M. Ibrahim,² S.-M. Jafri.²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI; ²Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI; ³Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI.
Introduction:We examined the utility of perioperative lactate values for the prediction of multiple post-transplant outcomes including length of hospital stay (LOS), acute cellular rejection (ACR),…
2016 American Transplant Congress
Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² C. Lassman,¹ R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,¹ E. Reed.¹
¹Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; ²Surgery, University of California-Los Angeles, Los Angeles, CA.
Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
2016 American Transplant Congress
Effect of Conversion to mTOR Inhibition on Allograft Fibrosis in Pediatric Liver Transplantation.
R. Fischer,¹ S. Foster,² A. Kats,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel.¹
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS.
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving liver allografts. These findings can lead to cirrhosis and graft failure. We compared two…
2016 American Transplant Congress
Hepatitis C Eradication with Sofosbuvir Based Regimens Leads to Significant Metabolic Changes in Post Orthotopic Liver Transplant Patients.
A. Morales,¹ M. Singla,² H. Greenwald,¹ S. Robertazzi,¹ C. Rodigas,¹ V. Washington,¹ R. Satoskar,¹ C. Smith.¹
¹MedStar Transplant Institute, Georgetown University Hospital, Washington, DC; ²Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD.
The purpose of this study was to assess the effect of hepatitis C virus (HCV) eradication with sofosbuvir based regimens on glycemic and lipid control…
2016 American Transplant Congress
Living Donor Liver Transplant Has Similar Outcome to Deceased Donor Liver Transplant for MELD > 25.
M. Al Sebayel,¹ F. Abaalkhail,^1,2 M. Shoukri,¹ H. Albahili,^1,2 S. Alabbad,¹ W. AlHamoudi,^1,2,3 H. Albeshbeshy,¹ H. Elsiesy.^1,2
¹Liver Transplantation, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; ²Alfaisal University, Riyadh, Saudi Arabia; ³Department of Gastroenterology, King Saud University, Riyadh, Saudi Arabia.
Background and Aims: Model for End-Stage Liver Disease (MELD) score is universally used to prioritize patients on the liver transplant (LT) waiting list. There has…
2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
S. Feng,¹ J. Bucuvalas,² A. Demetris,³ K. Spain,⁴ S. Kanaparthi,⁵ J. Magee,⁶ G. Mazariegos,³ The iWITH Investigators.⁷
¹UCSF, San Francisco; ²CCHMC, Cincinnati; ³U Pitt, Pittsburgh; ⁴Rho, Chapel Hill; ⁵ITN, Bethesda; ⁶U Mich, Ann Arbor; ⁷NIAID/NIDDK/ITN, Bethesda.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…
2016 American Transplant Congress
Glycine Is Graft Protective and Improves Kidney Function After Liver Transplantation: Data from HEGPOL-Trial.
A. Nickkholgh,¹ P. Schemmer,¹ G. Polychronidis,¹ S. Luntz,² E. Mayatepek,³ M. Büchler,¹ E. Klar.⁴
¹General, Abdominal and Transplant Surgery, Ruprecht-Karls University, Heidelberg, BW, Germany; ²Coordination Center for Clinical Trials (KKS), Heidelberg, BW, Germany; ³Department of General Pediatrics, Heinrich-Heine-University, Düsseldorf, RP, Germany; ⁴Department of Surgery, University of Rostock, Rostock, Germany.
Introduction: In experimental liver transplantation (LTx), glycine, a non-essential amino acid, has been shown to prevent the activation of Kupffer cells and to reduce ischemia/reperfusion…
2015 American Transplant Congress
Tobacco Use Is a Significant Risk Factor for Post-Transplant Biliary Complications
D. Dulaney, M. Dokus, M. Orloff, R. Kashyap.
Surgery, University of Rochester Medical Center, Rochester, NY.
Purpose: Biliary complications following liver transplantation are a significant source of morbidity, potentially leading to graft failure necessitating retransplantation. Smoking precipitates both microvascular and macrovascular…