Articles tagged "Liver transplantation"

2016 American Transplant Congress
Thorough Pre-Transplant Evaluation and Appropriate Case Selection Is the Mainstay for Better Survival in Recipients with Malignancy.
W. Yin.^1,2
¹Surgery, School of Medicine, Tzu Chi University, Hualien, Taiwan; ²Surgery, Dalin Tzu Chi General Hospital, Chia-I, Taiwan.
IntroductionMalignancy has become one of the three major causes of death after transplantation in the past decade and is thus increasingly important in all organ…
2016 American Transplant Congress
Predicting and Reducing 30-Day Readmission After Liver Transplant (OLT).
K. Eid, M. Elshamy, L. Louwers, B. Eghtesad, C. Quintini, K. Snyder, F. Aucejo, K. Hashimoto, M. Fujiki, C. Miller, D. Kelly.
Transplant Surgery, Cleveland Clinic Foundation, Cleveland, OH.
Background:Reducing early readmissions is a challenge. This study aimed to identify predictors of 30-day readmissions and interventions to minimize readmissions.Methods: Records of 523 adult OLT…
2016 American Transplant Congress
Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
2016 American Transplant Congress
Ideal Outcome After Liver Transplantation: An Exploratory Study Using Machine Learning Analyses to Leverage Long-Term Registry Data from Studies in Pediatric Liver Transplantation (SPLIT).
E. Hsu,¹ M. Shaffer,^1,2 R. Anand,³ V. Ng,⁴ J. Bucuvalas.⁵
¹University of Washington School of Medicine, Seattle, WA; ²Children's Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA; ³The EMMES Corporation, Rockville, MD; ⁴The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada; ⁵Cincinnati Children's Hospital and Medical Center, Cincinnati, OH.
We analyzed the Studies in Pediatric Liver Transplantation (SPLIT) registry dataset using heat map and random forests analyses (RFA) to determine if ideal outcome (IO)…
2016 American Transplant Congress
Biopsy-Proven Rejection in Children After Liver Transplantation Is Associated by an IL-12p40-Mediated Innate Immune Response Followed by Th1 T Cell Activation.
C. Falk,¹ I. Goldschmidt,² F. Mutschler,² E. Pfister,² F. Lehner,³ J. Keil,¹ C. Neudörfl,¹ A. Karch,⁴ R. Mikolajczyk,⁴ U. Baumann.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Bitte Wählen, Germany; ²Department of Pediatric Hepatology, Hannover Medical School, Hannover, Bitte Wählen, Germany; ³Department of Abdominal and Transplantation Surgery, Hannover Medical School, Hannover, Bitte Wählen, Germany; ⁴Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Germany.
Sustained by adaptive immune cells and their soluble mediators is well established for infection but it has not been demonstrated for solid organ transplantation in…
2016 American Transplant Congress
The Finances of Broader Sharing of Livers Following Share 35.
A. Harper,¹ E. Edwards,¹ R. Gilroy,² W. Chapman,³ D. Mulligan,⁴ G. Klintmalm.⁵
¹Research, UNOS, Richmond, VA; ²Univ.of Kansas Med Ctr, Kansas City, KS; ³Washington Univ, St Louis, MO; ⁴Yale Med Ctr, New Haven, CT; ⁵Baylor Univ, Houston, TX.
Background. After implementation of the “Share 35” policy in 2013, many centers and OPOs reported increased costs associated with broader sharing. The OPTN Liver and…
2016 American Transplant Congress
Pre-Transplant Loco-Regional Therapy for Hepatocellular Carcinoma and Post-Transplant Outcomes: A National Study.
M. Nazzal,¹ J. Chen,¹ K. Lentine,¹ M. Schnitzler,¹ J. Tuttle-Newhall,² C. Varma,¹ A. Taha,¹ A. Said,¹ H. Xiao,¹ H. Randall.¹
¹Saint Louis Univ, Saint Louis; ²East Carolina Univ, Greenville.
Currently most transplant centers use loco-regional therapy to bridge liver transplant (LT) candidates with hepatocellular carcinoma (HCC). However, limited data are available to support the…
2016 American Transplant Congress
Hospitalizations for Cardiovascular Disease After Liver Transplantation in the United States: Epidemiology, Outcomes, and Costs.
A. Mathur, Y.-H. Chang, D. Steidley, N. Khurmi, N. Katariya, A. Singer, W. Hewitt, K. Reddy, A. Moss.
Transplant Center, Mayo Clinic, Phoenix.
Background: Cardiovascular disease (CVD) is a leading cause of post-liver transplant death, and variable care patterns may affect outcomes. We aimed to describe epidemiology, outcomes,…
2016 American Transplant Congress
Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.
S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski.
The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.
Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…