Articles tagged "Liver transplantation"

2016 American Transplant Congress
Functional Status and Comorbidity Are Associated with High Costs After Liver Transplantation.
M. Serper, M. Rossi, T. Bitterman, A. Shaked, K. Olthoff.
University of Pennsylvania, Philadelphia.
Purpose: The purpose of this study was to identify the clinical characteristics associated with high costs of liver transplantation (LT) at a large transplant center…
2016 American Transplant Congress
A Comparative Intention-to-Treat Analysis of Liver Transplantation for HCC – Living Donor Liver Transplant vs. Deceased Donor Liver Transplant.
K. Tomiyama, N. Goldaracena, A. Barbas, M. Dib, G. Levy, L. Lilly, A. Ghanekar, I. McGilvray, E. Renner, M. Bhat, M. Selzner, M. Cattral, N. Selzner, P. Greig, D. Grant, G. Sapisochin.
Multi-Organ Transplant Program, University of Toronto, Toronto, ON, Canada.
IntroductionLiving donor liver transplantation (LDLT) can reduce waiting times and potentially decrease drop-out rates for cirrhotic patients with HCC. However, it has also been reported…
2016 American Transplant Congress
Outcomes of Ductoplasty in Right Lobe Living Donor Grafts with More Than One Bile Duct.
S. Kapoor, V. Varma, B. Nath, V. Kumaran.
Liver Transplantation & HPB Surgery, Kokilaben Dhirubhai Ambani Hospital & Medical Research Institute, Mumbai, Maharashtra, India.
Background:Biliary complications remain the Achilles's heel of LDLT, especially in the setting of multiple ducts in the right lobe graft. Hilar plate glissonian sheath preservation…
2016 American Transplant Congress
Diabetes Mellitus Status of the Donor and Prolonged Cold Ischemia Time Have a Synergistic Negative Effect on Graft Survival After Liver Transplantation.
I. Brüggenwirth,^1,2 N. Dolgin,¹ P. Martins,¹ B. Movahedi,¹ A. Ahearn,¹ R. Porte,² A. Bozorgzadeh.¹
¹Surgery, University of Massachusetts Medical Center, Worcester; ²Surgery, University Medical Center Groningen, Groningen, Netherlands.
Background: Both prolonged cold ischemia time (CIT) and a history of diabetes mellitus (DM) in the donor are associated with reduced graft survival after liver…
2016 American Transplant Congress
Results from 100 Consecutive Donation-After-Circulatory Death (DCD) Liver Transplants Using a Thrombolytic Protocol.
J. Seal, H. Bohorquez, N. Battula, E. Ahmed, D. Bruce, I. Carmody, R. Trevor, G. Tyson, S. Joshi, N. Bzowej, G. Therapondas, N. Girgrah, A. Cohen, G. Loss.
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
Background: In early 2010, our center implemented a thrombolytic protocol for DCD liver transplantation in an effort to reduce biliary complications and improve graft survival.…
2016 American Transplant Congress
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Protects Against Loss of Hepatic Integrity After Ischemia-Reperfusion Injury.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix (ECM)-associated protein…
2016 American Transplant Congress
Cardiovascular Prognosis and Adverse Cardiac Events After Orthotopic Liver Transplantation.
L. Potena, V. Manfredini, P. Prestinenzi, R. Alabrese, V. Bertuzzo, L. Borgese, M. Masetti, C. Morelli, F. Grigioni, A. Pinna.
University of Bologna, Bologna, Italy.
Cardiovascular (CV) disease is a major cause of morbidity and mortality among transplant candidate and recipients of noncardiac organs. Aiming to analyze the impact of…
2016 American Transplant Congress
Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² C. Lassman,¹ R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,¹ E. Reed.¹
¹Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; ²Surgery, University of California-Los Angeles, Los Angeles, CA.
Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
2016 American Transplant Congress
Effect of Conversion to mTOR Inhibition on Allograft Fibrosis in Pediatric Liver Transplantation.
R. Fischer,¹ S. Foster,² A. Kats,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel.¹
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS.
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving liver allografts. These findings can lead to cirrhosis and graft failure. We compared two…
2016 American Transplant Congress
Hepatitis C Eradication with Sofosbuvir Based Regimens Leads to Significant Metabolic Changes in Post Orthotopic Liver Transplant Patients.
A. Morales,¹ M. Singla,² H. Greenwald,¹ S. Robertazzi,¹ C. Rodigas,¹ V. Washington,¹ R. Satoskar,¹ C. Smith.¹
¹MedStar Transplant Institute, Georgetown University Hospital, Washington, DC; ²Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD.
The purpose of this study was to assess the effect of hepatitis C virus (HCV) eradication with sofosbuvir based regimens on glycemic and lipid control…