Articles tagged "Liver transplantation"

2022 American Transplant Congress
Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro¹⁰, J. Pawlowska¹¹, P. Czubkowski¹¹, R. Mikolajczyk¹², U. Baumann¹³, C. Falk¹⁴
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hannover; Hôpital Necker-Enfants Malades, Paris, France, ⁷Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Ospedali Riuniti di Bergamo, Bergamo, Italy, ¹¹Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹²German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹³Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, ¹⁴Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
2022 American Transplant Congress
Impact of Sarcopenia Using L3 and Thigh Skeletal Muscle Index on Clinical Outcomes in Liver Transplantation Recipient
M. Lim, J. Kim
Department of Surgery, Samsung Medical Cener, Seoul, Korea, Republic of
*Purpose: Sarcopenia is defined as loss of muscle mass and function. It has been reported as a significant risk factor for outcome after Liver transplantation…
2022 American Transplant Congress
Acute Cellular Rejection in Liver Transplant Recipients Following Vaccination Against Covid-19
R. Sarwar¹, O. Adeyi², N. Lim¹
¹Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, ²Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN
*Purpose: The coronavirus disease 2019 (COVID-19) global pandemic has seen the development of effective vaccines in record time. We report a series of five liver…
2022 American Transplant Congress
Evaluating the Performance and External Validity of Machine Learning-Based Prediction Models in Liver Transplantation: An International Study
T. Ivanics¹, D. So², M. P. Claasen³, D. Wallace⁴, M. Patel⁵, A. Gravely⁶, K. Walker⁷, T. Cowling⁷, L. Erdman⁸, G. Sapisochin³
¹University of Toronto - University Health Network, Toronto, ON, Canada, ²The Centre for Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³Multi-organ transplant program, University Health Network, Toronto, ON, Canada, ⁴Department of Health Services Research and policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁵Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Multi-organ transplant program, University of Toronto - University Health Network, Toronto, ON, Canada, ⁷Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ⁸The Centre of Computational Medicine, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: National liver transplant (LT) registries are curated in many countries. We compared data from three national registries and developed machine learning algorithm (MLA)-based models…
2022 American Transplant Congress
Analytical Evaluation and Comparison to STR of an Accurate and Sensitive Microchimerism Monitoring Tool for Liver Transplant Recipients
A. S. Kothari¹, C. Egidio¹, J. Miles², N. Gulbahce¹, S. Dholakia³, M. Grskovic⁴
¹Clinical Development, CareDx, South San Francisco, CA, ²Medical Affairs, CareDx, Brooklyn, NY, ³Medical Affairs, CareDx, South San Francisco, CA, ⁴CareDx, Brisbane, CA
*Purpose: Peripheral blood chimerism is associated with clinically relevant events post liver transplantation (LT). Accurate quantification of donor chimerism in LT recipients with ultra-sensitive chimerism…
2022 American Transplant Congress
Steatosis Following Liver Transplantation for Nonalcoholic Steatohepatitis is Associated with a Higher Rate of Cardiovascular Complications
W. Alhamoudi¹, S. Alqahtani², K. Bzeizi², A. Albenmousa², Y. Saleh², D. Broering², S. Alghamdi²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplantation, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
*Purpose: Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) worldwide. Objectives: to evaluate the prevalence of…
2022 American Transplant Congress
Liver Transplant Recipient Social Support Network: Impact on Clinical Outcomes
M. M. French¹, R. S. Mangus², R. Holmes³, A. Krause³, J. Sumner³, C. Kubal⁴, B. Ekser⁵, P. Mihaylov⁶, J. Fridell⁷, A. Lutz⁸
¹Social Work, Indiana University, Indianapolis, IN, ²Surgery, Indiana University, Indianapolis, IN, ³Department of Surgery, Indiana University, Indianapolis, IN, ⁴Department of Surgery, Indiana University Hospital, Indianapolis, IN, ⁵Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ⁶Department of Surgery, Indiana Univ School of Medicine, Indianapolis, IN, ⁷Indiana University School of Medicine, Indianapolis, IN, ⁸Department of Surgery, Indiana University, Fishers, IN
*Purpose: Health disparities are present in transplantation, just as in other areas of medicine. This is a retrospective review of liver transplant (LT) recipients to…
2022 American Transplant Congress
Initial Outcome of External Biliary Drainage Tube Insertion in Living Donor Liver Transplantation: Pure Laparoscopic Donor Hepatectomy Dominant Center Experience
E. Jang¹, S. Hong¹, S. Hong¹, S. Lee¹, S. Suh¹, E. Han¹, Y. Choi², N. Yi², K. Lee³, K. Suh⁴
¹Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³Seoul National University, Seoul, Korea, Republic of, ⁴Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Surgical technique advancements and enhanced perioperative management improved outcome in living donor liver transplantation (LDLT) recipients. However, biliary complication(BC) including biliary leakage(BL) and biliary…
2022 American Transplant Congress
Clinical Efficacy of Adjuvant Immunotherapy for Liver Transplant Recipients with Exceeding Japan Criteria of Hepatocellular Carcinoma Using Donor Liver Derived Natural Killer Cells
M. Ohira¹, Y. Imaoka², K. Sato³, K. Imaoka¹, N. Tanimine¹, H. Tahara¹, K. Ide¹, T. Kobayashi¹, Y. Tanaka¹, A. G. Tzakis⁴, S. Nishida⁵, H. Ohdan¹
¹Hiroshima University, Hiroshima, Japan, ²Hiroshima Uni., Hiroshima, Japan, ³Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ⁴Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH, ⁵Univ of Miami School of Medicine, Valhalla, NY
*Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is an indication for liver transplantation (LT). Immunosuppressive regimens currently used after…
2022 American Transplant Congress
Creating a Workflow for the Electronic Medical Record Allows Living Donor Liver Transplantation Programs to Track Candidates and Identify Areas for Optimization
A. Liapakis¹, R. Batra¹, E. Cohen², D. Haakinson¹, M. Schilsky¹, K. Ventura², D. Mulligan¹
¹Yale University School of Medicine, New Haven, CT, ²Yale New Haven Hospital, New Haven, CT
*Purpose: To provide a pathway to increase living donor liver transplantation (LDLT) opportunities through creation of a simple workflow algorithm embedded within the EPIC electronic…