Articles tagged "Liver transplantation"

2022 American Transplant Congress
The Impact of Yttium-90 Radioembolization on T Cell Phenotypes in Bridged to Transplant Hepatocellular Carcinoma Patients
K. Nunez, T. Sandow, P. Thevenot, A. Cohen
Ochsner Health System, New Orleans, LA
*Purpose: Response to locoregional therapy (LRT) in hepatocellular carcinoma (HCC) impacts both progression-free survival (PFS) and bridge to transplant success. Yttrium-90 (Y90) is an effective…
2022 American Transplant Congress
An International Multi-Institutional Comparison of Liver Transplantation for Hepatocellular Carcinoma: United States, United Kingdom, and Canada
T. Ivanics¹, D. Wallace², M. P. Claasen³, M. Patel⁴, W. Jassem⁵, K. Menon⁵, A. Suddle⁵, N. Heaton⁵, N. Mehta⁶, J. van der Meulen², G. Sapisochin³
¹University of Toronto - University Health Network, Toronto, ON, Canada, ²Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ³Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ⁴Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, ⁵Institute of Liver Studies, King's College Hospital, London, United Kingdom, ⁶UCSF, San Francisco, CA
*Purpose: Hepatocellular carcinoma (HCC) has become a leading indication for liver transplantation (LT) globally. Given the scarcity of organs, the general consensus has been that…
2022 American Transplant Congress
The Feasibility of Changing HCC MELD Exception Criteria to an Exclusive DCD-Only Option: A Strategy to Increase DCD Utilization
G. J. McKenna, P. Schultz, M. Finotti, M. Rosenzweig, A. Gupta, S. H. Lee, A. Wall, E. Martinez, J. Bayer, H. Fernandez, N. Onaca, R. Ruiz, G. Testa
Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
*Purpose: Outcomes of DCD liver transplantation is comparable to DBD but routine utilization of DCD liver grafts is surprisingly uneven in the US. A more…
2022 American Transplant Congress
Pre-Transplant Frailty Predicts Infection After Liver Transplant in a Multi-Center Study of Older Adults
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale SOM, New Haven, CT, ²Univ of CO, Aurora, CO, ³Stanford, Palo, Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a complex multi-system characterization of reduced physiologic reserve and functional decline in older adults. At the time of transplant, frailty has been…
2022 American Transplant Congress
Clinical Stratification of Pediatric Liver Transplant Recipients 4-5 Years Post-Transplant: 1^St Step Towards Personalized Management
W. Dixon¹, E. R. Perito¹, M. Tavakol¹, J. Bucuvalas², S. Feng¹
¹University of California, San Francisco, San Francisco, CA, ²Mount Sinai Kravis Children's Hospital and Recanati/Miller Transplantation Institute, Mount Sinai Health System, New York, NY
*Purpose: Recent surveillance biopsy studies strongly associate high normal ALT (>35U/L) with inflammatory histopathology and low normal ALT (15yrs (n=13; p=0.0006), chronic rejection (CR) diagnosis…
2022 American Transplant Congress
Significant Improvements, but Consistent Disparities in Survival for African Americans After Liver Transplantation
S. S. Keeling
Baylor College of Medicine, Houston, TX
*Purpose: Despite improvements in survival for all races in the past twenty years, African American patients have worse liver transplant outcomes after undergoing orthotopic liver…
2022 American Transplant Congress
Prolonged Preservation by Hypothermic Machine Perfusion Facilitates Logistics in Liver Transplantation: A European Observational Cohort Study
I. M. Brüggenwirth¹, M. Mueller², V. A. Lantinga¹, S. Camagni³, R. De Carlis⁴, L. De Carlis⁵, M. Colledan⁶, D. Dondossola⁷, M. Drefs⁸, J. Eden², D. Ghinolfi⁹, D. Koliogiannis¹⁰, G. Lurje¹¹, T. Manzia¹², D. Monbaliu¹³, P. Muisean¹⁴, D. Patrono¹⁵, J. Pratschke¹⁶, R. Romagnoli¹⁷, M. Rayar¹⁸, F. Roma¹⁴, A. Schlegel², P. Dutkowski², R. J. Porte¹, V. E. de Meijer¹
¹University Medical Center Groningen, Groningen, Netherlands, ²University Hospital Zurich, Zurich, Switzerland, ³ASST Papa Giovanni XXIII, Bergamo, Italy, ⁴ASST Grande Ospedale Metropolitano Niguarda, Niguarda, Italy, ⁵Niguarda Ca’ Granda Hospital, Niguarda, Italy, ⁶Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy, ⁷Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy, ⁸University of Munich, Munich, Germany, ⁹Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ¹⁰Hospital of the University of Munich, Munich, Germany, ¹¹Charité Universitätsmedizin Berlin, Berlin, Germany, ¹²Tor Vergata University, Rome, Italy, ¹³KU Leuven University Hospitals Leuven, Leuven, Belgium, ¹⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ¹⁵A. O. U. Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁶Charite Universitatsmedizin Berlin, Berlin, Germany, ¹⁷AOU Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁸CHU Pontchaillou, Rennes, France
*Purpose: A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver…
2022 American Transplant Congress
Older Donor Age is Associated with Worse Living Donor Liver Transplantation Outcomes in a National US Cohort
M. Kanneganti¹, K. M. Olthoff², T. Bittermann³
¹Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Department of Surgery, University of Pennsylvania, Philadelphia, PA, ³Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA
*Purpose: To evaluate the impact of increasing living donor (LD) age on living donor liver transplantation (LDLT) outcomes in the U.S.*Methods: A retrospective cohort of…
2022 American Transplant Congress
Pure Laparoscopic versus Open Right Hepatectomy in Living Liver Donors (Graft Weight Discrepancy)
J. Seo¹, S. Hong¹, S. Lee², S. Suh², S. Hong¹, E. Han¹, Y. Choi², N. Yi², K. Lee³, K. Suh¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Seoul National University, Seoul, Korea, Republic of
*Purpose: The studies of volumetric evaluation in pure laparoscopic donor hepatectomy (PLDH) are relatively less known than that of conventional donor hepatectomy. The aim of…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…