Articles tagged "Liver transplantation"

2022 American Transplant Congress
Pre-Transplant Frailty Predicts Infection After Liver Transplant in a Multi-Center Study of Older Adults
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale SOM, New Haven, CT, ²Univ of CO, Aurora, CO, ³Stanford, Palo, Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a complex multi-system characterization of reduced physiologic reserve and functional decline in older adults. At the time of transplant, frailty has been…
2022 American Transplant Congress
Clinical Stratification of Pediatric Liver Transplant Recipients 4-5 Years Post-Transplant: 1^St Step Towards Personalized Management
W. Dixon¹, E. R. Perito¹, M. Tavakol¹, J. Bucuvalas², S. Feng¹
¹University of California, San Francisco, San Francisco, CA, ²Mount Sinai Kravis Children's Hospital and Recanati/Miller Transplantation Institute, Mount Sinai Health System, New York, NY
*Purpose: Recent surveillance biopsy studies strongly associate high normal ALT (>35U/L) with inflammatory histopathology and low normal ALT (15yrs (n=13; p=0.0006), chronic rejection (CR) diagnosis…
2022 American Transplant Congress
Significant Improvements, but Consistent Disparities in Survival for African Americans After Liver Transplantation
S. S. Keeling
Baylor College of Medicine, Houston, TX
*Purpose: Despite improvements in survival for all races in the past twenty years, African American patients have worse liver transplant outcomes after undergoing orthotopic liver…
2022 American Transplant Congress
Assessing Safety of Using ECMO-Supported Donors in Abdominal Transplantation
P. J. Altshuler¹, A. P. Shah¹, J. M. Glorioso¹, W. R. Maley¹, A. M. Frank¹, C. B. Ramirez¹, H. Dang¹, S. West², R. Hasz, Jr.², A. S. Bodzin¹
¹Department of Surgery, Thomas Jefferson University, Philadelphia, PA, ²Gift Of Life Donor Program, Philadelphia, PA
*Purpose: Organ donors supported by extracorporeal membrane oxygenation (ECMO) are historically considered high-risk and are judiciously utilized. Here we explore the safety of using organs…
2022 American Transplant Congress
Long-Term Follow Up of Solid Organ Transplantation Using Hepatitis C Virus Positive Donor for Hepatitis C Virus Negative Recipients
H. Sogawa¹, I. Lee², K. Okumura³, R. Bodin⁴, D. C. Wolf⁴, B. Partiula⁴, A. Dhand⁴, M. Kai⁵, S. Ohira⁵, R. Misawa¹, G. Veillette⁶, D. John¹, S. Nishida⁷, T. Diflo⁶
¹Division of Intra-abdominal Organ Transplant, Department of Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ²Department of Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ³Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY, ⁴Department of Medicine, Westchester Medical Center/ New York Medical College, Valhalla, NY, ⁵Cardiothoracic Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ⁶Westchester Medical Center, Valhalla, NY, ⁷Westchester Medical Center/ New York Medical College, Valhalla, NY
*Purpose: To determine the effects of transplanting an HCV + solid organ to an uninfected patient who is on the transplant waiting list. Outcomes include…
2022 American Transplant Congress
Efficacy and Safety of Delayed, Low-Dose Valganciclovir in High-Risk Cytomegalovirus Liver Transplant Recipients
S. Anders¹, A. Freeman¹, L. Hutchinson¹, U. Kaszubski¹, M. Janusek¹, A. Hooter², D. Raymond², C. Nguyen²
¹Ochsner Medical Center, New Orleans, LA, ²Xavier University, New Orleans, LA
*Purpose: The goal of this study was to compare the safety and efficacy of a delayed valganciclovir (VGCV) dosing protocol for cytomegalovirus (CMV) prophylaxis in…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
2022 American Transplant Congress
Variation in Donor Liver Rejection Rates for Donor Quality Among US Transplant Centers
M. Anderson¹, T. Gilbert², M. Englesbe¹, S. Waits¹
¹Michigan Medicine Transplant Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI
*Purpose: Optimal utilization of all viable donor livers is a public health imperative. As no standardized criteria exist for assessment of donor quality, differential utilization…
2022 American Transplant Congress
Impaired Left Ventricular Global Longitudinal Strain: Clinical Presentation and Outcomes in Liver Transplantation Recipients without Arrhythmia or Structural Heart Disease
M. B. Hammami, J. Grossman, P. Xue, H. Allaham, K. Eagan, S. Gottlieb, C. Hong, L. Wang, C. Bhati, D. Maluf, K. Shetty, N. Urrunaga
University of Maryland School of Medicine, Baltimore, MD
*Purpose: Assess the prevalence and characteristics of patients without arrhythmia or structural heart disease (SHD) but with impaired pre-transplant left ventricular global longitudinal strain (GLS)…
2022 American Transplant Congress
Area Deprivation Index is Associated with Worse Patient Survival Following Adult Liver Transplantation
J. Hendele¹, J. Perkins², J. Nichols³, A. Dick¹
¹Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA, ²Clinical and Bio-Analytics Transplant Laboratory (CBATL), University of Washington, Division of Transplant Surgery, Department of Surgery, Seattle, WA, ³School of Medicine, University of Washington, Seattle, WA
*Purpose: Area Deprivation Index (ADI) has been utilized as a granular measure of local socioeconomic status for nearly two decades. This study is the first…