Articles tagged "Liver transplantation"

2016 American Transplant Congress
Living Donor Liver Transplant Has Similar Outcome to Deceased Donor Liver Transplant for MELD > 25.
M. Al Sebayel,¹ F. Abaalkhail,^1,2 M. Shoukri,¹ H. Albahili,^1,2 S. Alabbad,¹ W. AlHamoudi,^1,2,3 H. Albeshbeshy,¹ H. Elsiesy.^1,2
¹Liver Transplantation, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; ²Alfaisal University, Riyadh, Saudi Arabia; ³Department of Gastroenterology, King Saud University, Riyadh, Saudi Arabia.
Background and Aims: Model for End-Stage Liver Disease (MELD) score is universally used to prioritize patients on the liver transplant (LT) waiting list. There has…
2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
S. Feng,¹ J. Bucuvalas,² A. Demetris,³ K. Spain,⁴ S. Kanaparthi,⁵ J. Magee,⁶ G. Mazariegos,³ The iWITH Investigators.⁷
¹UCSF, San Francisco; ²CCHMC, Cincinnati; ³U Pitt, Pittsburgh; ⁴Rho, Chapel Hill; ⁵ITN, Bethesda; ⁶U Mich, Ann Arbor; ⁷NIAID/NIDDK/ITN, Bethesda.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…
2016 American Transplant Congress
Glycine Is Graft Protective and Improves Kidney Function After Liver Transplantation: Data from HEGPOL-Trial.
A. Nickkholgh,¹ P. Schemmer,¹ G. Polychronidis,¹ S. Luntz,² E. Mayatepek,³ M. Büchler,¹ E. Klar.⁴
¹General, Abdominal and Transplant Surgery, Ruprecht-Karls University, Heidelberg, BW, Germany; ²Coordination Center for Clinical Trials (KKS), Heidelberg, BW, Germany; ³Department of General Pediatrics, Heinrich-Heine-University, Düsseldorf, RP, Germany; ⁴Department of Surgery, University of Rostock, Rostock, Germany.
Introduction: In experimental liver transplantation (LTx), glycine, a non-essential amino acid, has been shown to prevent the activation of Kupffer cells and to reduce ischemia/reperfusion…
2016 American Transplant Congress
Use of Autotransfusion During Liver Transplantation for Hepatocellular Carcinoma Does Not Increase Recurrence.
A. Gupta, M. Ramsay, G. Saracino, T. Anthony, R. Goldstein, G. McKenna, N. Onaca, R. Ruiz, G. Klintmalm, P. Kim.
Baylor University Medical Center, Dallas, TX.
IntroductionAutotransfusion (AT) is rarely used in liver transplantation of hepatocellular carcinoma (HCC) patients due to the fear of disease transmission. Leukocyte depleting filters (LDF) can…
2016 American Transplant Congress
Living Donor Liver Transplantation for Sick Patients with MELD Score ≥ 35.
R.-S. Soong,¹ Y.-C. Wang,¹ C.-H. Cheng,¹ T.-H. Wu,¹ C.-F. Lee,¹ T.-J. Wu,¹ H.-S. Chou,¹ K.-M. Chan,¹ C.-S. Lee,² W.-C. Lee.¹
¹Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Taoyuan, Taiwan; ²Hepatology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan.
Background: The liver transplant candidates with MELD score ≥ 35 were very sick and with high mortality without liver transplantation. All these patients are in…
2016 American Transplant Congress
Renal Function Decline Is Higher in the First Year After Liver Transplantation: Final Results from the Italian Observational Study SURF.
A. Giacomoni,¹ M. Cescon,² G. Magini,³ F. Picciotto,⁴ U. Cillo,⁵ M. Senzolo,⁵ G. Vennarecci,⁶ P. De Simone.⁷
¹AO Niguarda, Milano, Italy; ²AO S.Orsola-Malpighi, Bologna, Italy; ³AO Papa Giovanni XXIII, Bergamo, Italy; ⁴AO Cardarelli, Napoli, Italy; ⁵AOU di Padova, Padova, Italy; ⁶O S.Camillo, Roma, Italy; ⁷AOU Cisanello, Pisa, Italy.
SURF registry was designed to investigate the evolution of renal function in Italian adult liver transplant (LT) recipients by: exploring the prevalence of chronic kidney…
2016 American Transplant Congress
Defining Frailty in Liver Transplant Recipients.
L. Louwers,¹ K. Eid,¹ J. Plescia,¹ N. Presser,¹ J. Muntean,¹ M. Kattan,² K. Chagrin,² C. Miller,¹ D. Kelly.¹
¹Surgery, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
PURPOSETo define frailty in the liver transplant (OLT) population to optimize care and assist in predicting post OLT outcomes.METHODSAll adult primary OLT patients from 01/2010…
2016 American Transplant Congress
Histone Deacetylase-2 Gene Deletion in Mice Mitigates Liver Ischemia/Reperfusion Injury.
D. Murken,¹ D. Aufhauser Jr,¹ Z. Wang,² G. Ge,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2016 American Transplant Congress
Incidence of and Risk Assessment for Adverse Cardiovascular Outcomes Following Liver Transplantation: A Systematic Review.
M. Konerman,¹ D. Fritze,² R. Weinberg,³ E. Spengler,¹ C. Sonnenday,² P. Sharma.¹
¹Hepatology, Univ of Michigan, Ann Arbor, MI; ²Transplantation Surgery, Univ of Michigan, Ann Arbor, MI; ³Cardiology, Univ of Michigan, Ann Arbor, MI.
Purpose: Cardiovascular (CV) events remain a major source of morbidity and mortality following liver transplantation (LT). This review evaluates the incidence of and risk assessment…
2016 American Transplant Congress
Outcomes of Liver Grafts from Donors with Very High Transaminases.
P. Martins, A. Rawson, P. Mahboub, B. Movahedi, N. Dolgin, I. Bruggenwirth, A. Bozorgzadeh.
Department of Surgery, Transplant Division, University of Massachusetts, Worcester, MA.
Introduction: Traditionally, elevation of transaminases has been broadly used as markers of hepatic ischemic injury and crucial parameters for liver graft assessment. We wanted to…