Articles tagged "Liver transplantation"

2016 American Transplant Congress
Machine Perfusion (MP) at 21[deg]C Simulates Hibernation Metabolic Pathways in a Non-Hibernator Mammal.
B. Banan, S. Dobrowolski, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Background: Hibernation is a complex and multi stage process that leads to unique metabolic changes over an extended period of time. Regulatory genes and transcription…
2016 American Transplant Congress
Decline of HCV RNA and Core Antigen: Predictors of Achieving SVR in Transplant Recipients Undergoing DAA-Therapy.
S. Pischke,³ V. Proske,¹ S. Polywka,⁴ M. Lütgehetmann,⁴ M. Lang,¹ S. Stauga,¹ L. Fischer,¹ A. Lohse,³ B. Nashan,² M. Sterneck.¹
¹University Transplant Center, University Hospital Hamburg Eppendorf, Hamburg, Germany; ²Department of Hepatobiliary Surgery and Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany; ³Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Greece; ⁴Department of Microbiology, University Hospital Hamburg Eppendorf, Hamburg, Germany.
Background:DAA-treatment of hepatitis C virus (HCV) re-infections in orthotopic liver transplant (OLT) recipients has been demonstrated to be safe and effective in controlled studies, but…
2016 American Transplant Congress
Cytokine Storm in Acute Post-Hepatectmy Phase Associates with Liver Injury and Impaired Liver Regeneration.
Y. Xu,^1,2 N. Navarro-Alvarez,¹ J. Dong,² J. Markmann,¹ H. Yeh.¹
¹Transplantation Division, Massachusetts General Hospital, Boston, MA; ²Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
Background Posthepatectomy liver failure and its transplant counterpart, small-for-size syndrome, remain poorly understood. Large increases in IL-6 are associated with poor allograft function and IL-6…
2016 American Transplant Congress
Really Old (>84 Years) Deceased Donor Livers Can Save Lives.
A. Friedman, E. Marquez, K. DelliCarpini.
LiveOnNY, New York, NY.
Avoiding death of the liver transplant candidate who depends on the inadequate organ supply requires careful strategy. Nevertheless, transplantation of livers from potential donors older…
2016 American Transplant Congress
Role of Donor Hemodynamic Trajectory in Determining Graft Survival in Liver Transplantation from Donation After Circulatory Death Donors.
D. Firl, K. Hashimoto, C. O'Rourke, J. Fung, B. Eghtesad.
Cleveland Clinic, Cleveland.
This retrospective study of 87 donation after circulatory death (DCD) liver transplants from 2007-2015 tested the hypothesis that donor hemodynamic trajectory following withdrawal effects graft…
2016 American Transplant Congress
Thorough Pre-Transplant Evaluation and Appropriate Case Selection Is the Mainstay for Better Survival in Recipients with Malignancy.
W. Yin.^1,2
¹Surgery, School of Medicine, Tzu Chi University, Hualien, Taiwan; ²Surgery, Dalin Tzu Chi General Hospital, Chia-I, Taiwan.
IntroductionMalignancy has become one of the three major causes of death after transplantation in the past decade and is thus increasingly important in all organ…
2016 American Transplant Congress
Predicting and Reducing 30-Day Readmission After Liver Transplant (OLT).
K. Eid, M. Elshamy, L. Louwers, B. Eghtesad, C. Quintini, K. Snyder, F. Aucejo, K. Hashimoto, M. Fujiki, C. Miller, D. Kelly.
Transplant Surgery, Cleveland Clinic Foundation, Cleveland, OH.
Background:Reducing early readmissions is a challenge. This study aimed to identify predictors of 30-day readmissions and interventions to minimize readmissions.Methods: Records of 523 adult OLT…
2016 American Transplant Congress
Resveratrol Attenuates Liver IRI by Regulating Macrophage Activation Through SIRT1/p19/p53 Pathway.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: Sirtuin1 (SIRT1), a NAD+-dependent type III histone/protein deacetylase, plays a key role in inflammation responses and stress resistance. Although SIRT1 may regulate innate activation…
2016 American Transplant Congress
Ideal Outcome After Liver Transplantation: An Exploratory Study Using Machine Learning Analyses to Leverage Long-Term Registry Data from Studies in Pediatric Liver Transplantation (SPLIT).
E. Hsu,¹ M. Shaffer,^1,2 R. Anand,³ V. Ng,⁴ J. Bucuvalas.⁵
¹University of Washington School of Medicine, Seattle, WA; ²Children's Core for Biomedical Statistics, Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, WA; ³The EMMES Corporation, Rockville, MD; ⁴The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada; ⁵Cincinnati Children's Hospital and Medical Center, Cincinnati, OH.
We analyzed the Studies in Pediatric Liver Transplantation (SPLIT) registry dataset using heat map and random forests analyses (RFA) to determine if ideal outcome (IO)…
2016 American Transplant Congress
Biopsy-Proven Rejection in Children After Liver Transplantation Is Associated by an IL-12p40-Mediated Innate Immune Response Followed by Th1 T Cell Activation.
C. Falk,¹ I. Goldschmidt,² F. Mutschler,² E. Pfister,² F. Lehner,³ J. Keil,¹ C. Neudörfl,¹ A. Karch,⁴ R. Mikolajczyk,⁴ U. Baumann.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Bitte Wählen, Germany; ²Department of Pediatric Hepatology, Hannover Medical School, Hannover, Bitte Wählen, Germany; ³Department of Abdominal and Transplantation Surgery, Hannover Medical School, Hannover, Bitte Wählen, Germany; ⁴Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Germany.
Sustained by adaptive immune cells and their soluble mediators is well established for infection but it has not been demonstrated for solid organ transplantation in…