Articles tagged "Liver transplantation"

2016 American Transplant Congress
Functional Status and Comorbidity Are Associated with High Costs After Liver Transplantation.
M. Serper, M. Rossi, T. Bitterman, A. Shaked, K. Olthoff.
University of Pennsylvania, Philadelphia.
Purpose: The purpose of this study was to identify the clinical characteristics associated with high costs of liver transplantation (LT) at a large transplant center…
2016 American Transplant Congress
3D-FLM (First, Last, Max): A Novel Summative Measure of Hepatocellular Carcinoma (HCC) Tumor Burden Predicts HCC Recurrence After Liver Transplantation (LT).
E. Nordstrom,¹ J. Dodge,² J. Gralla,¹ K. Campbell,¹ C. Palmer,¹ S. Biggins.¹
¹Univ. Colorado, Aurora; ²UCSF, San Francisco.
Risk of recurrent HCC post-LT depends on tumor aggressiveness, pre-LT HCC burden and treatment response while waiting for LT. Standard measures of pre-LT HCC burden…
2016 American Transplant Congress
Clinical Usefulness of mRECIST Response to Chemoembolization for Recurrence Prediction of Hepatocellular Carcinoma in Living Donor Liver Transplantation.
C. Cho, K. Kim, S. Kim, J. Lee, J. Lee, J. Kim, G.-S. Choi, C. Kwon, J.-W. Joh, N. Lee.
Surgery, Samsung Medical Center, Seoul, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background Predicting risk for recurrence of hepatocellular carcinoma (HCC) following living donor liver transplantation (LDLT) is clinically important.Methods We performed a retrospective study for assessment…
2016 American Transplant Congress
Is MELD Score a Significant Predictor of Post-Transplant Mortality? An Old Issue with Simple Answer.
A. Rahnemai-Azar,¹ J. Perkins,¹ M. Montenovo,¹ S. Rayhill,¹ R. Bakthavatsalam,¹ N. Leca,² C. Blosser,² I. Di Castro,² R. Bhattacharya,³ J. Reyes,¹ L. Sibulesky.¹
¹Surgery, University of Washington, Seattle, WA; ²Nephrology, University of Washington, Seattle, WA; ³Hepatology, University of Washington, Seattle, WA.
The predictive value of the Model for End-Stage Liver Disease (MELD) score for post-transplant survival has been under constant debate. Some investigators tried to introduce…
2016 American Transplant Congress
Pre-Mortem Cannulation and NECMO Preservation for DCD Liver Transplantation.
P. Ruiz,¹ M. Gastaca,¹ A. Valdivieso,¹ A. Ventoso,¹ I. Palomares,¹ M. Prieto,¹ J. Bustamante,² P. Salvador,² J. Ortiz de Urbina.¹
¹Liver Surgery and Liver Transplant Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain; ²Hepatology and Liver Transplant Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain.
Introduction: Herein, we present the short-term results of a controlled DCD liver transplantation program with pre-mortem cannulation and normothermic extracorporeal membrane oxygenation (NECMO) preservation.Material and…
2016 American Transplant Congress
Protective Effects of Nrf2 Over-Activation in Myeloid Cells During Hepatic Ischemia Reperfusion Correlates with Stat3 Signaling in Hepatocytes.
C. Harberg,¹ L.-Y. Lee,¹ S. Werner,² D. Johnson,³ J. Johnson,³ D. Foley.¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland; ³Pharmaceutical Sciences, University of Wisconsin School of Pharmacy, Madison, WI.
Ischemia-reperfusion injury (IRI) is a consequence of liver resection and liver transplantation. The Nrf2-antioxidant response element pathway is a key mediator of cellular defense against…
2016 American Transplant Congress
The Use of Perioperative Lactate Values as Markers for Adverse Outcomes in Liver Transplantation.
B. Rao,¹ A. Yoshida,³ M. Ibrahim,² S.-M. Jafri.²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI; ²Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI; ³Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI.
Introduction:We examined the utility of perioperative lactate values for the prediction of multiple post-transplant outcomes including length of hospital stay (LOS), acute cellular rejection (ACR),…
2016 American Transplant Congress
Innate Immune Signaling During Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² C. Lassman,¹ R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,¹ E. Reed.¹
¹Pathology and Lab Medicine, University of California-Los Angeles, Los Angeles, CA; ²Surgery, University of California-Los Angeles, Los Angeles, CA.
Background: Orthotopic liver transplantation (OLT) success is hampered by cellular damage elicited by ischemia-reperfusion injury (IRI) which lowers allograft survival. Research using murine models has…
2016 American Transplant Congress
Effect of Conversion to mTOR Inhibition on Allograft Fibrosis in Pediatric Liver Transplantation.
R. Fischer,¹ S. Foster,² A. Kats,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel.¹
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS.
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving liver allografts. These findings can lead to cirrhosis and graft failure. We compared two…
2016 American Transplant Congress
Hepatitis C Eradication with Sofosbuvir Based Regimens Leads to Significant Metabolic Changes in Post Orthotopic Liver Transplant Patients.
A. Morales,¹ M. Singla,² H. Greenwald,¹ S. Robertazzi,¹ C. Rodigas,¹ V. Washington,¹ R. Satoskar,¹ C. Smith.¹
¹MedStar Transplant Institute, Georgetown University Hospital, Washington, DC; ²Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, MD.
The purpose of this study was to assess the effect of hepatitis C virus (HCV) eradication with sofosbuvir based regimens on glycemic and lipid control…