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Articles tagged "Liver transplantation"

  • 2016 American Transplant Congress

    Same Policy, Different Impact: Center and Regional Effects of SHARE 35 Liver Allocation.

    D. Murken,1 A. Peng,1 D. Aufhauser Jr,1 D. Goldberg,2 M. Levine.1

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Medicine, University of Pennsylvania, Philadelphia, PA.

    Introduction: Early studies of national data suggest that Share-35 implementation was associated with more liver transplants, fewer discards, and lower waitlist mortality, without worsening of…
  • 2016 American Transplant Congress

    Increased Utilization of High Risk Deceased Donors with Share 35 Does Not Affect Outcomes in Liver Transplantation.

    M. Boktour, A. Saharia, D. Victor, S. Gordon-Burroughs, C. Mobley, R. McFadden, V. Ankoma-Sey, J. Galati, A. Gaber, H. Monsour, R. Ghobrial.

    Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist Hospital, Houston, TX.

    Background: Demand for livers from deceased donors exceeds supply after Share 35 in June 2013. This leads liver transplant centers to consider high risk deceased…
  • 2016 American Transplant Congress

    Cholangioscopy in Liver Transplant Recipients.

    U. Agbim,1 E. Verna,1 R. Brown, Jr,2 A. Sethi.1

    1Columbia University, New York; 2Cornell University, New York.

    BackgroundBiliary complications in the post-liver transplant population are common and are a source of significant morbidity, which are preferably managed, if technically feasible, by endoscopic…
  • 2016 American Transplant Congress

    Caval Replacement versus Piggyback Liver Transplantation: The Toronto Experience.

    A. Barbas, M. Dib, N. Goldaracena, M. Marquez, G. Sapisochin, D. Al-Adra, S. McCluskey, I. McGilvray.

    General Surgery, Multi-Organ Transplant, University of Toronto, Toronto, ON, Canada.

    Background:Caval replacement (CR) and piggyback (PB) techniques for deceased donor liver transplantation (DDLT) each have inherent advantages and disadvantages with no consensus on the optimal…
  • 2016 American Transplant Congress

    Sublingual Tacrolimus in Liver Transplantation: A Valid Option?

    M. Moreno Gonzales,1 L. Myhre,2 T. Taner.1

    1Division of Transplantation Surgery, Mayo Clinic, Rochester, MN; 2Department of Pharmacy, Mayo Clinic, Rochester, MN.

    Introduction. Oral tacrolimus (Tac) is currently the pilar of maintenance immunosuppression following solid organ transplantation and the most common route of drug delivery. Recent studies…
  • 2016 American Transplant Congress

    The Impact of Thromboelastography on Resuscitation in Pediatric Liver Transplantation.

    K. Gonzalez,1 K. Curiel,1 B. Dalton,1 V. Fioravanti,1 W. Andrews,1 B. Wicklund,2 R. Hendrickson.1

    1Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO; 2Department of Hematology, Children's Mercy Hospital, Kansas City, MO.

    Introduction: Thromboelastography (TEG) directs effective resuscitation in adult surgical and trauma patients. There is little data on TEG use in pediatrics. In 2011 we began…
  • 2016 American Transplant Congress

    Sudden Increase in Allocation Score for Pediatric Liver Transplant Candidates Predicts Waitlist Mortality.

    X. Luo, D. Mogul, A. Massie, D. Segev.

    JHU, Baltimore.

    Allocation for deceased donor livers is prioritized in the U.S. by waitlist mortality, as predicted by PELD for children<12 years, and MELD for individuals>12 years.…
  • 2016 American Transplant Congress

    AT1R Antibodies at 1-Year Negatively Impact 5-Year Native Renal Function in Liver Transplant Recipients.

    J. O'Leary,1 A. Philippe,2 H. Heidecke,2 R. Freeman,1 L. Jennings,1 R. Catar,2 G. Klintmalm,1 D. Dragun.2

    1Baylor Simmons Transplant Insttute, Baylor University Medical Center, Dallas, TX; 2Internal Medicine, Charite, Berlin, Germany.

    Angiotensin II Type-1 Receptor (AT1R) antibodies have been associated with pulmonary hypertension, renal allograft loss, and fibrosis progression in liver allograft recipients especially if combined…
  • 2016 American Transplant Congress

    IL-2 Therapy Restores the Impaired Function of Regulatory T Cells Induced by Calcineurin Inhibitors in Liver Transplantation.

    G. Whitehouse, E. Gray, S. Mastoridis, E. Kodela, A. Sanchez-Fueyo, M. Martinez-Llordella.

    Liver Science Department, King's College London, London, United Kingdom.

    CD4+CD25+FOXP3+ regulatory T cells (Tregs) have an essential role in immune regulation and constitute a key target for cellular immunotherapies in transplantation. IL-2 is critical…
  • 2016 American Transplant Congress

    Evaluation of the Long-Term Outcomes with Everolimus After Calcineurin Inhibitor Withdrawal: 36M Results of the H2304 and PROTECT Extension Studies.

    L. Fischer,1,2 J. Fung,1 H. Metselaar,1 G. Kaiser,1,2 P. Schemmer,2 P. Neuhaus,2 G. Dong,3 P. Lopez,4 P. Bernhardt,4 H. Schlitt.2

    1H2304 study group, Hamburg, Germany; 2PROTECT study group, Hamburg, Germany; 3Novartis Pharmaceuticals Corporation, East Hanover, NJ; 4Novartis Pharma AG, Basel, Switzerland.

    Background: The H2304 and PROTECT studies demonstrated reduced nephrotoxicity with everolimus (EVR)-based calcineurin inhibitor (CNI; cyclosporine: CsA, tacrolimus: TAC)-free regimens at Month (M) 12. Here,…
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