Articles tagged "Liver transplantation"

2017 American Transplant Congress
National Trends in Utilization of Donation After Cardiac Death Donor Livers for Transplantation.
S. Kubal,¹ R. Mangus,¹ B. Ekser,¹ R. Amos,² J. Fridell.¹
¹Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; ²Indiana Donor Network, Indianapolis, IN
Background: Optimizing utilization of donation after cardiac death (DCD) livers is imperative to address organ shortage. Understanding factors that contribute to DCD liver discards is…
2017 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.
W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medcine, Baltimore, MD
Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
2017 American Transplant Congress
Subclinical Histologic Findings Are Observed in 25% of Stable Adult Liver Transplant Recipients (ALTRs) Screened for Immunosuppression Withdrawal (ISW): OPTIMAL (NCT02533180).
S. Chandran,¹ M. Abecassis,² J. Levitsky,² S. Feng,³ A. Humar,⁴ J. Emond,⁵ G. Klintmalm,⁶ A. Demetris,⁴ K. Much,⁷ L. Sun,¹ A. Priore,⁸ D. Ikle,⁷ N. Bridges,⁸ M. DesMarais,¹ B. Burrell,⁹ J. Markmann.¹⁰
¹ITN, San Francisco; ²Northwestern, Chicago; ³UCSF, San Francisco; ⁴UPMC, Pittsburgh; ⁵Columbia, New York; ⁶Baylor, Dallas; ⁷Rho, Chapel Hill; ⁸NIAID/NIH, Bethesda; ⁹ITN, Bethesda; ¹⁰MGH, Boston
OPTIMAL is a 6-center ISW study in non-autoimmune, non-HCV ALTRs ≥3 yrs post-transplant (tx). Studies have shown a correlation between portal inflammation associated with tissue…
2017 American Transplant Congress
A Brief Frailty Assessment and Outcomes Among Candidates for Liver Transplantation.
M. Serper, K. Dwinnells, T. Bittermann, K. Olthoff.
Medicine, University of Pennsylvania, Philadelphia, PA; Surgery, Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA
Introduction: As frailty correlates with post-transplant outcomes, brief frailty measures are needed in clinical practice to appropriately risk stratify LT candidates. We used an abbreviated…
2016 American Transplant Congress
Large Single-Center Experience of Sofosbuvir and Ledipasvir Therapy for the Treatment of Post-Liver Transplant Patients with Hepatitis C Virus.
J. Wedd, R. Ford, J. Norvell, S. Parekh, N. Cheng, N. Young, A. Patel, R. Maheshwari, R. Vora, O. Mgbemena, J. Spivey, A. Pillai.
Medicine, Emory University, Atlanta, GA.
Background/Aims: Controlled trials of direct acting antiviral therapy for Hepatitis C Virus (HCV) show impressive sustained virologic response (SVR) rates, but post-transplant data of sofosbuvir…
2016 American Transplant Congress
Portal Vein Complication After Living Donor Right Hepatectomy.
D.-H. Jung, S.-G. Lee, S. Hwang, K.-H. Kim, C.-S. Ahn, D.-B. Moon, T.-Y. Ha, G.-W. Song, W.-J. Kim, S.-H. Kim, W.-H. Kang, J.-H. Kwon, E.-K. Jwa, H.-D. Cho.
Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
BackgroundLiving donor hepatectomy may carry a significant risk of morbidity and mortality for the otherwise healthy donor. Portal vein (PV) complication after donor hepatectomy is…
2016 American Transplant Congress
Effect of Modifying Life Support Withdrawal Practices on Outcomes of Donation After Circulatory Death in Liver Transplantation: A Meta-Analysis.
Y. Cao,^1,2 S. Shahrestani,³ H. Chew,^2,4 M. Crawford,⁵ P. Macdonald,^1,2,4 J. Laurence,^3,5,7 W. Hawthorne,^3,6 K. Dhital,^1,2,4 H. Pleass.^3,5,6
¹Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; ²Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; ³Sydney Medical School, University of Sydney, Sydney, NSW, Australia; ⁴Cardiac Transplant Unit, St. Vincent's Hospital, Sydney, NSW, Australia; ⁵Australian National Liver Transplant Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia; ⁶The Department of Surgery, Westmead Hospital, Sydney, NSW, Australia; ⁷Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Aim. Donor warm ischaemic time is identified as the main risk factor for poor outcomes in liver transplantation using donation after circulatory death (DCD) compared…
2016 American Transplant Congress
The Impact of Gender Discordance on Graft Survival Among Liver Transplant Recipients.
J. Moore, X. Luo, A. Massie, T. Purnell, D. Mogul, D. Segev.
Johns Hopkins School of Medicine, Baltimore.
Past studies have shown inferior liver graft survival in gender-discordant recipient/donor pairings compared to gender-matched pairings, particularly in male recipients of female donor livers. However,…
2016 American Transplant Congress
LACE Index Risk Assessment Tool Predicts Liver Transplant Readmissions.
A. Masoumi,¹ R. Barth,² J. LaMattina,² D. Bruno,² L. Hebert,¹ N. Schluterman,³ S. Hanish.²
¹University of Maryland Medical Center, Baltimore, MD; ²Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; ³Department of Epidemiology, University of Maryland School of Public Health, Baltimore, MD.
Background:One-fifth of Medicare patients are readmitted to the hospital an annual cost of $17.4 billion. The LACE Index (Length of stay, Acuity of the admission,…
2016 American Transplant Congress
Outcomes of Arterial and Venous Conduits for Vessel Reconstruction in Liver Transplantation.
J. Tan,¹ G. Oniscu.²
¹University of Edinburgh, Edinburgh, United Kingdom; ²Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Background: The use of hepatic artery (HA) and portal vein (PV) conduits is a recognised alternative technique in vessel reconstruction during liver transplantation. The hepatic…