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Articles tagged "Liver transplantation"

  • 2017 American Transplant Congress

    Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).

    E. Beal,1 J. Kim,1 D. Hayes Jr.,2 K. Washburn,1 B. Whitson,1 S. Black.1

    1Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Departments of Pediatrics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH

    Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…
  • 2017 American Transplant Congress

    Effect of Hepatitis C (HCV) Treatment on Rejection Incidence and Severity in Post-Liver Transplant Patients.

    C. Skillin, M. Mba, B. Madani, C. Frenette.

    Organ Transplant, Scripps Clinic, La Jolla, CA

    Introduction: Hepatitis C remains an important source of morbidity and mortality post liver transplant. Little is known about the long term effects of direct acting…
  • 2017 American Transplant Congress

    Sirolimus Prolonged Survival After Living Donor Liver Transplantation for HCC Beynd Milan Criteria; Outcome of a Multicenter Prospective Randomized Phase II Trial (ClinicalTrials.gov Identifier: NCT01374750).

    K.-W. Lee,1 S.-H. Kim,2 N.-J. Yi,1 S.-K. Hong,1 G. Yoon,1 H. Kim,1 D. Oh,1 S.-S. Han,2 S.-J. Park,2 K.-S. Suh.1

    1Department of Surgery, Seoul National University, Seoul, Republic of Korea; 2Center for Liver Cancer, National Cancer Center, Goyangsi, Republic of Korea

    Background:It is unclear whether the reported benefit of mTORi in LT for HCC is from direct effect of mTOR inhibitors. We aimed to compare directly…
  • 2017 American Transplant Congress

    TIM-3 – CEACAM1 Checkpoint Regulation of T-Cell Activation and Hepatocellular Function in Liver Transplantation.

    K. Nakamura,1 S. Kageyama,1 M. Kujawski,3 R. Sosa,2 E. Reed,2 A. Zarrinpar,1 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Dept. Surgery, UCLA, Los Angeles, CA; 2Dept. Pathology, UCLA, Los Angeles, CA; 3Dept. Molecular Immunology, City of Hope, Duarte, CA

    Background/Aim: We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CD66a; CM1; Carcinoembryonic Antigen-Related Cell Adhesion…
  • 2017 American Transplant Congress

    Comparing the Role of Post-Transplant Readmissions and Bed Days on Total One Year Cost of Care.

    W. Bannister,1 M. Schnitzler,2 J. Tao,1 A. Bonagura,1 B. Laihinen,1 F. Irwin,1 C. Horstman.1

    1Complex Medical Conditions, Optum, UnitedHealth Group, Eden Prairie, MN; 2Surgery, St. Louis University, St. Louis, MO

    This study examines the marginal impact of readmissions and total bed days during the 90-day period following transplant in order to better understand drivers of…
  • 2017 American Transplant Congress

    Center Volume Does Not Influence the Risk Associated with Using High DRI Donor Livers.

    S. Black,1 E. Beal,1 K. Mumtaz,2 D. Hayes Jr.,3 A. El-Hinnawi,1 K. Washburn,1 D. Tumin.4

    1Department of Surgery, OSUWMC, Columbus, OH; 2Department of Internal Medicine, OSUWMC, Columbus, OH; 3Department of Internal Medicine, OSUWMC, Columbus, OH; 4Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH

    Background: High risk donor allografts potentially reduce survival after liver transplantation (LT), but increase access. We evaluated whether differences in patient mortality associated with using…
  • 2017 American Transplant Congress

    Hepatic Artery and Biliary Complications in Liver Transplant Recipients with Radioembolization Bridging Treatment for Hepatocellular Carcinoma.

    S. Radunz,1 J. Treckmann,1 F. Saner,1 S. Müller,2 J. Theysohn,3 A. Paul,1 T. Benkö.1

    1General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany; 2Nuclear Medicine, University Hospital Essen, Essen, Germany; 3Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany

    Locoregional treatments are commonly applied in hepatocellular carcinoma (HCC) patients as a bridge to liver transplantation to prevent tumor progression during waiting time. We hypothesized…
  • 2017 American Transplant Congress

    Favorable Long-Term Prognosis of Hepatitis B Surface Antigen Positive Intrahepatic Cholangiocarcinoma for Both Hepatic Resection and Incidental Liver Transplantation via Inhibiting Cancer-Associated Lymphangiogenesis.

    J. Gu, S. Jeong, M. Sha, J. Zhang, Q. Xia.

    Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    Background: In recent years, a few publications indicated that hepatitis B virus (HBV) infection is associated with the prognosis of patients with ICC after resection.…
  • 2017 American Transplant Congress

    Antibiotic Conservatorship in Orthotopic Liver Transplantation.

    J. Yee,2 D. Clark,2 R. Hogen,1,2 K. Dhanireddy,1 S. Biswas,2 J. Cobb,2 K. Matsushima,2 D. Grabo,2 A. Strumwasser.2

    1Solid Organ Transplantation, Keck Hospital of USC, Los Angeles, CA; 2Trauma, Acute Care Surgery, Surgical Critical Care, LAC+USC Medical Center, Los Angeles, CA

    Post-orthotopic liver transplantation (OLT) infections, especially multidrug resistant organisms (MDRO), are implicated in poorer outcomes, fueling efforts to elucidate risk factors for hospital acquired infections.…
  • 2017 American Transplant Congress

    Risk Analysis of Patients with Proven Coronary Artery Disease Undergoing Liver Transplant.

    J. Balogh, K. Lunsford, D. Nguyen, E. Gravis, O. Cercio, C. Mobley, A. Saharia, S. Gordon Burroughs, A. Gaber, R. Ghobrial.

    Houston Methodist Hospital, Houston, TX

    ObjectivesCoronary artery disease is increasing common in liver transplant (LT) candidates due to the aging population. We sought to longitudinally evaluate of outcomes of LT…
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