Articles tagged "Liver transplantation"

2018 American Transplant Congress
Recipient HO-1 Deficiency Decreases Post-Transplant Graft HO-1 Expression and Exacerbates Liver Transplant Damage
S. Kageyama,¹ K. Nakamura,¹ T. Ito,¹ A. Aziz,¹ B. Ke,¹ R. Sossa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Many preclinical studies on protective functions of heme oxygenase-1 (HO-1; hsp32) in orthotopic liver transplantation (OLT) have encouraged application of HO-1 inducing regimens in clinical…
2018 American Transplant Congress
Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C
C. Chan,¹ E. Agudelo,² J. Haydek,³ M. Hoteit,⁴ M. Laurito,⁵ J. Norvell,³ T. Schiano,⁶ N. Terrault,² E. Verna,⁵ A. Yang,¹ J. Levitsky.¹
¹Northwestern University, Chicago, IL; ²UCSF, San Francisco, CA; ³Emory University, Atl, GA; ⁴University of Pennsylvania, Philadelphia, PA; ⁵Columbia University, NY, NY; ⁶Mount Sinai, NY, NY.
Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…
2018 American Transplant Congress
Medication Adherence: Does Where You Live Matter?
S. Wadhwani,¹ S. Taylor,¹ C. Brokamp,¹ W. Guo,¹ E. Shemesh,² J. Bucuvalas.¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati; ²Mount Sinai School of Medicine, New York.
Background & Objectives: Medication non-adherence remains problematic in pediatric liver transplant (LT)[mdash]estimates suggest that up to 53% of adolescents are non-adherent. We leveraged data from…
2018 American Transplant Congress
Long-Term Medical, Financial, Psychosocial, and Overall Health-Related Quality of Life after Living Donation in Liver Transplantation
J. Emamaullee,¹ L. Sher,¹ T-.L. Fong,² K. Dhanireddy,¹ S. Zielsdorf,¹ C. Romero,¹ N. Wade,¹ Y. Genyk.¹
¹Surgery, University of Southern California, Los Angeles, CA; ²Keck School of Medicine at the University of Southern California, Los Angeles, CA.
Background: The long-term impact of living donation (LD) in liver transplantation on health-related quality of life (HRQOL) has not been well characterized. This study was…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…
2018 American Transplant Congress
Does Biliary Duct Reconstruction Technique Impact Liver Transplantation Outcomes?
R. Shahbazov,¹ M. Kessel,² K. Knapp,² F. Azari,² S. Tsutsui,³ A. Nickkholgh,¹ D. Maluf,¹ S. Pelletier.¹
¹Surgery, University of Virginia Health System, Charlottesville, VA; ²School of Medicine, University of Virginia Health System, Charlottesville, VA; ³Surgery, University of Pennsylvania, Philadelphia, PA.
Introduction: The rate of biliary complication after liver transplantation remains high. The choice of biliary reconstruction technique may depend on the patient's primary disease, possible…
2018 American Transplant Congress
Waitlist Candidates Who Travel for Liver Transplantation and the Donor Organs They Receive
J. Ge, J. Lai.
Medicine, UCSF, San Francisco, CA; Medicine, UCSF, San Francisco, CA.
Background:Geographic disparities in access to liver transplantation (LT) has led to candidates seeking LT outside their home UNOS region (“Travelers”). Little is known about their…
2018 American Transplant Congress
Reduction in Circulating CD19⁺CD24⁺CD27⁺ Regulatory B Cell Frequency Predicts Acute Rejection in Liver Transplant Patients
H. Zhou, Z. Rao, Y. Lu, J. Rao, J. Gu, L. Lu, Y. Xia.
Liver Transplant Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Accumulating evidence suggests that regulatory B cells (Bregs) play an important role in modulating inflammation and autoimmune diseases. However, whether Bregs regulate acute liver…
2018 American Transplant Congress
A Long-Term Experience with Expansion of Milan Criteria for Liver Transplant Recipients
S. Commander,¹ B. Shaw,¹ L. Washburn,² D. Yoeli,² A. Rana,² J. Goss.²
¹Duke University, Durham, NC; ²Baylor College of Medicine, Houston, TX.
Background: The Milan Criteria (MC) have historically determined eligibility for transplantation for hepatocellular carcinoma (HCC). The United Network for Organ Sharing (UNOS) Region 4 expanded…
2018 American Transplant Congress
De Novo Use of Extended Released Tacrolimus (Meltdose, Envasus^R)) after OLT – Does the Colonic Resorption Influences the Outcome?
T. Soliman, G. Györi, M. Hofmann, A. Salat, S. Rockenschaub, G. Berlakovich.
Department of Transplantation, Medical University of Vienna, Vienna, Austria.
Introduction: Immunosuppression after OLT has reached a quite high standard with an excellent evidence base. However, there is still a lack of data for the…