Articles tagged "Liver transplantation"

2022 American Transplant Congress
Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Solid Organ Transplant
H. Sweiss¹, D. Zeilmann¹, J. Escamilla², R. Hall¹, S. Bhayana¹, R. Patel¹, C. Long²
¹University Health - University Hospital, San Antonio, TX, ²College of Pharmacy, University of Incarnate Word, San Antonio, TX
*Purpose: To evaluate the safety and efficacy of glucagon-like peptide-1 receptor agonists (GLP1-RA) in solid organ transplant (SOT).*Methods: This retrospective review included adult kidney, liver,…
2022 American Transplant Congress
Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients
N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ²Hiroshima University, Hiroshima, Japan
*Purpose: High-mobility group box 1 (HMGB-1) is an inflammatory mediator which becomes an uncontrollable lethal factor when released in excess from the nucleus or the…
2022 American Transplant Congress
Evolution of the Need for Transplant Evaluations for Liver Failure Decompensation After TIPS
N. Kemmer¹, V. Sureshkumar², L. Grater³, G. Hoots⁴, S. Agrawal¹, K. Robichaux⁵, M. Gosselin³, S. Mohammed⁵, A. Kumar⁶, J. Buggs⁷
¹Transplant Hepatology, Tampa General Hospital, Tampa, FL, ²Lake Erie College of Osteopathic Medicine, Bradenton, FL, ³University of Tampa, Tampa, FL, ⁴Radiology, Tampa General Hospital, Tampa, FL, ⁵University of South Florida, Tampa, FL, ⁶Morsani College of Medicine, University of South Florida, Tampa, FL, ⁷Transplant Surgery, Tampa General Hospital, Tampa, FL
*Purpose: Portal hypertension is described as an increased pressure gradient between the portal and systemic circulation which can result in severe complications. Transjugular Intrahepatic Portosystemic…
2022 American Transplant Congress
Association Between CT Measurements of Body Composition Before Liver Transplantation and Post-Transplantation Outcomes
Y. Liu¹, O. Shafaat¹, K. Jackson¹, J. Motter¹, B. Boyarsky¹, M. Latif¹, F. Yuan¹, E. King¹, A. Zaheer¹, R. Summers², D. Segev¹, M. McAdams-DeMarco¹, C. Weiss¹
¹Johns Hopkins University, Baltimore, MD, ²NIH Clinical Center, Bethesda, MD
*Purpose: Various methods exist for measuring body composition using computed tomography (CT) scans; however, it is unclear which components best predict post-liver transplantation (LT) outcomes.…
2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
M. D. Nazzal¹, K. Kurashima², J. Bettag², A. Chen², S. Bruno², A. Nagarapu², J. Van Nispen¹, J. Krebs², J. Teckman², D. Carpenter³, D. Hermelin³, C. Varma¹, A. Jain²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pediatrics, Saint Louis University, Saint Louis, MO, ³Pathology, Saint Louis University, Saint Louis, MO
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…
2022 American Transplant Congress
Normothermic Machine Perfusion in Liver Transplantation – Seven Year Experience at a Single North American Centre
J. Hefler¹, D. L. Izuierdo¹, G. Meeberg², M. Bral¹, B. Anderson¹, K. Dajani¹, N. Kneteman¹, D. L. Bigam¹, A. Shapiro¹
¹Department of Surgery, University of Alberta, Edmonton, AB, Canada, ²Alberta Health Services, Edmonton, AB, Canada
*Purpose: Machine perfusion for preservation of liver grafts before transplantation has risen in prominence over the past decade. Normothermic machine perfusion (NMP), in particular, has…
2022 American Transplant Congress
Secular Trends in Development of ESRD Following Liver Transplant
J. M. Ruck¹, L. Zeiser¹, A. Massie², D. Segev³, E. King¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins School of Medicine, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD
*Purpose: End-stage renal disease (ESRD) post-liver transplant (LT) is associated with increased mortality, but ESRD incidence and risk factors in LT recipients (LTRs) remain poorly…
2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…
2022 American Transplant Congress
Successful Utilization of Advanced Diabetes Technology to Optimize Glucose Control as a Bridge to Simultaneous Liver and Pancreas Transplantation
M. M. Stumpf¹, S. Lee¹, E. Marriner¹, S. Rao¹, J. Oberholzer², S. Pelletier³
¹University of Virginia, Charlottesville, VA, ²University of Illinois at Chicago, Charlottesville, VA, ³University of Virginia Health System, Charlottesville, VA
*Purpose: We present the case of a 20 year old female with history of autoimmune hepatitis diagnosed in 2014, treated with tacrolimus, and insulin dependent…
2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
R. Sindhi¹, X. Shao², C. Ashokkumar¹, T. Pastinen³, R. Sindhi⁴
¹Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²National Research Council Canada, Digital Technologies Research Centre, National Research Council Canada, Ottawa, ON, Canada, ³University of Missouri-Kansas City School of Medicine, Kansas City, MO, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…