Articles tagged "Liver transplantation"

2018 American Transplant Congress
Living Donor Liver Transplantation for Alcoholic Liver Disease: Data from the A2ALL Study
H. Braun, J. Dodge, J. Grab, S. Syed, G. Roll, C. Freise, J. Roberts, N. Ascher.
Surgery, University of California, San Francisco, San Francisco, CA.
The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is primarily from single Asian centers. We investigated LDLT outcomes for ALD…
2018 American Transplant Congress
Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis
I. Mikova,¹ M. Neroldova,² J. Hubacek,² D. Dlouha,² L. Kolesar,³ M. Jirsa,² E. Honsova,⁴ E. Sticova,⁴ V. Lanska,⁵ J. Spicak,¹ P. Trunecka.¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ²Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ³Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Background & Aims: The rs58542926 c.449C>T (p.E167K) polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is one of genetic factors predisposing to nonalcoholic fatty liver…
2018 American Transplant Congress
Predictors of Graft Survival amongst Recipients of Liver Allografts with Prolonged Cold Ischemic Time (CIT)
J. Steggerda,¹ K. Kim,¹ D. Malinoski,² M. Bloom.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Surgery, Oregon Health Science University, Portland, OR.
Background: CIT is an independent risk factor for worse outcomes in liver transplantation (LT). Factors contributing to improved graft survival in organs with CIT ≥12…
2018 American Transplant Congress
Donor Hepatectomy Time in Donation after Circulatory Death Donors is an Independent Risk Factor for the Development of Biliary Strictures and Early Graft Loss after Transplantation
O. van Leeuwen,¹ M. van Reeven,² M. Fujiyoshi,¹ V. de Meijer,¹ R. de Kleine,¹ M. de Boer,¹ J. de Jonge,² J. Ijzermans,² W. Polak,² R. Porte.¹
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Liver transplantation (LT) from donors after circulatory death (DCD) is associated with an increased risk of non-anastomotic biliary strictures (NAS) and early graft loss…
2018 American Transplant Congress
Kidney after Liver Transplant: A Matched Pair Analysis
M. Eerhart, J. Reyes, J. Danobeitia, L. Zitur, P. Chlebeck, L. Fernandez.
Surgery, University of Wisconsin, Madison, WI.
Background: Kidney after liver (KAL) transplantation is the best therapeutic option for patients with ESRD after liver transplantation (OLT). Current allocation policies create a safety…
2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
M. Ningappa, C. Ashokkumar, Q. Sun, B. Higgs, K. Soltys, G. Bond, G. Mazariegos, R. Sindhi.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…
2018 American Transplant Congress
Rituximab Induction to Prevent the Recurrence of PSC after Liver Transplantation-The Lessons Learned from ABO-Incompatible Living Donor Liver Transplantation-
Y. Yamada,¹ K. Hoshino,¹ M. Shinoda,¹ H. Obara,¹ S. Uemoto,³ T. Kaido,³ H. Okajima,³ T. Yagi,⁴ T. Yoshizumi,⁵ Y. Inomata,⁶ T. Hibi,⁶ K. Kubota,⁷ T. Suzuki,⁸ Y. Kitagawa,¹ H. Egawa,² T. Kuroda.¹
¹Surgery, Keio University School of Medicine, Tokyo, Japan; ²Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; ³Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery, Kyoto University, Kyoto, Japan; ⁴Hepato-Biliary and Pancreatic Surgery, Okayama University, Okayama, Japan; ⁵Department of Surgery, Kyushu University, Fukuoka, Japan; ⁶Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; ⁷Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan; ⁸Department of Pediatric Surgery, Fujita Health University School of Medicine, Aichi, Japan.
Background: Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national…
2018 American Transplant Congress
Surgical Categorization Improve Outcomes and Organ Utilization in Liver Transplant
H. Bohorquez,^1,2 H. Sharma,¹ D. Bruce,¹ A. Cohen,^1,2 C. Carmody,^1,2 J. Seal,¹ E. Bugeaud,¹ D. Sonnier,¹ A. Mathur,¹ D. Marroquin,¹ M. Voltz,¹ D. Lucia,¹ G. Loss.^1,2
¹Multi-Organ Transplant Institute, Ochsner Helath System, New Orleans, LA; ²School of Medicine, University of Queensland, New Orleans, LA.
Background: Liver transplant (LT) varies greatly in technical complexity due to factors such as prior surgery, obesity, and portal vein thrombosis (PVT). This must be…
2018 American Transplant Congress
Impact of Positive Donor Blood Cultures in Liver Transplant Recipients
D. Bley, D. Lo, G. Lyon III, R. Subramanian, S. Todd.
Emory University Hospital, Atlanta, GA.
The purpose of this study was to describe the bacteremia transmission rate of transplanting livers from donors with positive bacterial blood cultures into liver transplant…
2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
T. Ito, F. Kaldas, K. Nakamura, S. Kageyama, A. Aziz, R. Busuttil, J. Kupiec-Weglinski.
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…