Articles tagged "Liver transplantation"

2018 American Transplant Congress
National Landscape of HIV+ Liver Transplant Candidates
A. Shaffer,¹ A. Thomas,¹ A. Massie,¹ S. Gustafson,² J. Snyder,² B. Shelton,³ R. Reed,³ J. Locke,³ D. Segev,¹ C. Durand.¹
¹JHU, Baltimore; ²SRTR, Minneapolis; ³UAB, Birmingham.
The annual number of HIV+ liver transplant (LT) recipients has increased >10-fold since 2002. However, candidate HIV-status is not collected by UNOS, and the national…
2018 American Transplant Congress
Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ M. Kujawski,² T. Ito,¹ A. Aziz,¹ D. Oncel,¹ B. Ke,¹ R. Sossa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Molecular Immunology, City of Hope, Duarte, CA; ³Pathology, UCLA, Los Angeles, CA.
We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…
2018 American Transplant Congress
Derivation and Prospective External Validation of Prediction Models for Acute Kidney Injury in Adult Liver Transplant Recipients
Q. Zhao,¹ Z. Guo,¹ M. Chen,¹ S. Ma,¹ J. Lin,⁴ C. Zhang,² M. Han,³ X. He.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China; ²Department of Hepatobiliary Surgery, Guangdong General Hospital, Guangzhou, China; ³Organ Transplant Department, The Eastern Hospital of the First Affiliated Hospital of SYSU, Guangzhou, China; ⁴Department of Hepatobiliary Surgery, The Third People's Hospital of Shenzhen, Shenzhen, China.
BACKGROUND: Acute kidney injury (AKI) is common in patients after liver transplantation, and has a marked impact on the perioperative and long-term morbidity and mortality.…
2018 American Transplant Congress
The Effect of Donor-Recipient Gender Matches on Living Donor Liver Transplantation
J. Han, Y. You, H. Choi, B. Kwak, D. Kim.
Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
PurposeSome investigators reported that the donor-recipient gender mismatches influence on long-term graft survival after deceased donor liver transplantation. The aim of this study was to…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
Potential Living Donors Identified through Social Media
S. Weeks, K. Kumar, J. Konel, E. King, M. Henderson, A. Cameron, J. Garonzik Wang.
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
Purpose: We previously described a smartphone application that harnesses social media to increase potential living donors among kidney and liver transplant candidates. We compared potential…
2018 American Transplant Congress
SIRT1-Ikaros Axis Promotes Macrophage M2 Polarization and Protects Liver Graft from Ischemia-Reperfusion Injury
K. Nakamura,¹ S. Kageyama,¹ X. Li,² A. Aziz,¹ R. Sosa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²NIEHS, Durham, NC; ³Pathology, UCLA, Los Angeles, CA.
Although pre-clinical studies have reported the efficacy of Sirtuin 1 (SIRT1) to protect livers from ischemia-reperfusion injury, its clinical relevance in liver transplantation (LT) has…
2018 American Transplant Congress
Private Insurance is Associated with Reduce Access to HCV Therapy after Liver Transplantation
D. Axelrod,¹ M. Schnitzler,² B. Kasiske,³ G. Hess,⁴ R. Bloom,⁵ F. Gordon,¹ H. Randall,² K. Lentine.²
¹Lahey Clinic, Burlington; ²Saint Louis U, St. Louis; ³SRTR, Minneapolis; ⁴Symphony Health, Conshohocken; ⁵U Penn, Philadelphia.
Effective treatment for hepatitis C virus (HCV) infection has revolutionized post liver transplant (LTx) care. Administration of direct-acting antiviral agents (DAAs) after HCV+ LTx results…
2018 American Transplant Congress
Risk Factors for Chronic Opioid Use after Liver Transplantation
J. Fleming, D. Taber, B. O'Brien, N. Patel, N. Pilch, R. Gilbert, L. Wilson, Z. Elmaasarani, S. Ball, P. Mauldin, P. Baliga.
MUSC, Charleston, SC.
Opioid use is associated with increased readmissions and mortality in the liver transplant (OLTx) population. The aim of our study was to identify risk factors…
2018 American Transplant Congress
Long-Term Risk of Solid Organ De Novo Malignancies after Liver Transplantation: A French National Study on 11226 Patients
O. Seree, M. Altieri, J. Dumortier, GReF2.
Réseau Régional de Cancérologie Onco-Basse Normandie, Herouville St-Clair, France; Service d'Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, CHU CAEN Hôpital Côte de Nacre, Caen, France; Hospices Civils de Lyon, Lyon, France.
Background and aims: De novo malignancies are one of the major late complications and cause of death after liver transplantation (LT). Using extensive data from…