Articles tagged "Liver transplantation"

2018 American Transplant Congress
Impact of Direct Acting Antiviral Agents (DAAs) for Hepatitis C Virus (HCV)-Induced Liver Diseases on Registration and Outcome on Waiting List (WL) for Liver Transplant (LT)
C. Antoine,¹ C. Jasseron,¹ F. Conti,² S. Dharancy,³ C. Duvoux,⁴ A. Coilly.⁵
¹Medical and Scientific Department, Agence de la Biomedecine, Agence de la Biomedecine, La Plaine Saint Denis, Saint Denis, France; ²Department of Hepatology, University Hospital La Pitie, Paris, France; ³Department of Hepatology, University Hospital Huriez, Lille, Nord Pas de Calais, France; ⁴Department of Hepatology, University Hospital Henri Mondor, Créteil, Val de Marne, France; ⁵Department of Hepatology, University Hospital Paul Brousse, Villejuif, Val de Marne, France.
2d-generation DAAs have dramatically improved the management of patients with HCV, including patients with advanced diseases. In France, since 2013, DAA have been largely used,…
2018 American Transplant Congress
T Cell Exhaustion Contributes to Operational Tolerance of Liver Allografts in Pediatric Liver Transplant Recipients
B. Ramaswami,¹ M. Marrari,² O. Yoshida,⁵ X. Guo,³ W. Hoffman,³ C. Bentlejewski,² D. Metes,¹ A. Demetris,^1,2 A. Zeevi,² A. Thomson,¹ G. Mazariegos,⁴ G. Chalasani.^1,3
¹Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ²Pathology, University of Pittsburgh, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA; ⁴Children's Hospital, University of Pittsburgh, Pittsburgh, PA; ⁵Gastroenterology, Ehime University Graduate School of Medicine, Toon-shi, Ehime-ken, Japan.
Operational tolerance in the absence of immunosuppression can be successfully attained in pediatric liver transplant recipients. Although DSA are observed in a proportion of operationally…
2018 American Transplant Congress
Influence of Initial Tumor Burden and Wait Times on Post-Transplant Outcomes after Down-Staging of Hepatocellular Carcinoma (HCC)
N. Mehta, J. Dodge, F. Yao.
UCSF, San Francisco.
Background: A new national policy has adopted the UNOS Region 5 down-staging protocol for liver transplant (LT) in HCC meeting the following inclusion criteria -…
2018 American Transplant Congress
The Use of LiMAx for Evaluating Donor Livers on Normothermic Machine Perfusion
J. Schurink,¹ J. de Haan,² M. Verstegen,¹ H. Metselaar,³ J. Ijzermans,¹ J. de Jonge.¹
¹Surgery, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ²Intensive Care Medicine, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ³Gastroenterology, Erasmus MC, Rotterdam, Zuid Holland, Netherlands.
Due to the organ shortage, inferior quality livers from donors after circulatory arrest (DCD) are offered to relieve mortality on the waiting list. The threshold…
2018 American Transplant Congress
The Utility and Futility of Extra-Corporeal Membrane Oxygenation in Liver Transplant Recipients
B. Nguyen, K. Dhanireddy, Y. Genyk, N. Kaur.
University of Southern California, Los Angeles, CA.
Extra-corporeal membrane oxygenation (ECMO) is a therapeutic modality used to treat refractory hypoxemia, and help support cardiogenic shock. These conditions are seen in liver transplant…
2018 American Transplant Congress
Predicting Liver Allograft Discard: The Discard Risk Index
A. Rana, M. Kueht, N. Galvan, R. Cotton, T. Miloh, C. O'Mahony, J. Goss.
Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Background: An index that predicts liver allograft discard can effectively grade allografts and can be used to preferentially allocate marginal allografts to aggressive centers. Aim:…
2018 American Transplant Congress
Racial Disparities in Post-Liver Transplant Survival before and after Share 35 Implementation
K. Ross,¹ R. Lynch,² R. Patzer.^1,2
¹Department of Epidemiology, Rollins School of Public Health, Atlanta, GA; ²Emory Transplant Center, Atlanta, GA.
Background: The Share 35 policy was intended to improve equity in access to liver transplantation by broadening regional sharing of livers for the sickest patients…
2018 American Transplant Congress
Advanced Liver Care and Salvage Transplantation Improves Outcomes for Patients with Cirrhosis Requiring Abdominal General Surgical Procedures
D. Milgrom,¹ N. Valsangkar,¹ J. Kays,¹ T. Liang,¹ J. Butler,¹ C. Kubal,¹ M. Maluccio,¹ A. Tector,² L. Koniaris.¹
¹Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; ²Department of Transplant Surgery, University of Alabama School of Medicine, Birmingham, AB.
Introduction: Historically, abdominal general surgical procedures on cirrhotic patients carry up to an 80% mortality rate. We hypothesized outcomes of cirrhotic patients requiring abdominal surgical…
2018 American Transplant Congress
Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplantation
A. Thomson, A. Humar, F. Lakkis, S. Styn, A. Zahorchak, C. Macedo, D. Metes.
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Purpose: We have embarked on a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation…
2018 American Transplant Congress
Comparison of Tobacco Consumption versus Marijuana Consumption in Liver Transplant Recipients
P. Serrano Rodriguez, R. Watkins, L. Jurgevich, D. Gerber, A. Nayyar, J. Jadi, C. Moses, C. Desai.
Abdominal Transplant Surgery, The University of North Carolina, Chapel Hill, NC.
The long term effects of smoking tobacco have been widely reported, from cardiovascular disease, to pulmonary complications and cancer, the effect of Marijuana has not…