Articles tagged "Liver transplantation"

2018 American Transplant Congress
Clinical Application of Mesenchymal Stromal Cells with a Simplified Protocol for ABO Incompatible Liver Transplantation in Severe Hepatic Failure Patients
Y. Zhang,^1,2 J. Zheng,^1,2 J. Cai,^1,2 J. Zhang,^1,2 K. Zeng,^1,2 J. Yao,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Objective The purpose of this study was to test the safety and efficacy of mesenchymal stromal cells (MSCs) treatment with a simplified protocol for ABO…
2018 American Transplant Congress
Normothermic Machine Perfusion (NMP) Preservation for Human Liver Transplantation in the Cleveland Clinic
Q. Liu, D. Pezzati, A. Hassan, B. Soliman, P. Grady, S. Maikhor, G. Iuppa, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Cleveland Clinic, Cleveland, OH.
NMP is a novel preservation method for liver grafts. We transplanted 15 human livers after NMP to test the safety and feasibility of NMP on…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
Examples of the Observer Effect in Transplantation- Unintended Consequences of Regulation and Selected Outcome Metrics
A. Rana, M. Kueht, N. Galvan, R. Cotton, C. O'Mahony, J. Goss.
Abdominal Transplantation, Baylor College of Medicine, Houston, TX.
Introduction: The influence of an observer on the phenomena being observed is designated as the observer effect. It is our aim to demonstrate that an…
2018 American Transplant Congress
Effect of HLA Antibodies on Graft Survival in Adult Live Donor Liver Transplantation
M. Simpson,¹ M. Akoad,¹ F. Gordon,¹ Y-.L. Cheah,¹ C. Simon,¹ J. Pomposelli,² E. Pomfret.²
¹Transplantation, Lahey Hospital & Medical Center, Burlington, MA; ²Transplantation, University of Colorado Medical Center, Aurora, CO.
The relevance of HLA antibodies in liver transplantation is currently being re-evaluated. While hyperacute rejections are not an issue, antibody effects on long-term outcomes are…
2018 American Transplant Congress
Liver Retransplantation and Renal Failure: The Benefit of Simultaneous Kidney Transplant
J. Berumen,¹ V. Irine,² S. Mita,² S. Gabriel,¹ M. Kristin.¹
¹Department of Surgery, University of California San Diego, San Diego, CA; ²Department of Medicine, University of California San Diego, San Diego, CA.
Liver retransplantation has poor survival compared to primary liver transplant. Renal failure is a proven negative risk factor for survival with retransplant. Our aim was…
2018 American Transplant Congress
Measuring and Monitoring Equity in Access to Deceased Donor Liver Transplants
D. Stewart, A. Robinson, A. Harper, D. Klassen.
UNOS, Richmond.
Background: In 2016, the Organ Procurement and Transplantation Network (OPTN) developed a methodology to measure equity in deceased donor kidney allocation and has adapted it…
2018 American Transplant Congress
Regional Variation in the Outcomes of MELD-Na Based Liver Allocation
L. Chau,¹ D. Moonka,² K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S. Nagai.¹
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI.
Introduction: While there is known geographic discrepancy in waitlist and transplant outcomes in the MELD era, there is a paucity in understanding of these variations…
2018 American Transplant Congress
Kidney after Liver Transplant: A Matched Pair Analysis
M. Eerhart, J. Reyes, J. Danobeitia, L. Zitur, P. Chlebeck, L. Fernandez.
Surgery, University of Wisconsin, Madison, WI.
Background: Kidney after liver (KAL) transplantation is the best therapeutic option for patients with ESRD after liver transplantation (OLT). Current allocation policies create a safety…
2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
M. Ningappa, C. Ashokkumar, Q. Sun, B. Higgs, K. Soltys, G. Bond, G. Mazariegos, R. Sindhi.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…