Articles tagged "Liver transplantation"

2018 American Transplant Congress
Long-Term Risk of Solid Organ De Novo Malignancies after Liver Transplantation: A French National Study on 11226 Patients
O. Seree, M. Altieri, J. Dumortier, GReF2.
Réseau Régional de Cancérologie Onco-Basse Normandie, Herouville St-Clair, France; Service d'Hépato-Gastroentérologie, Nutrition et Oncologie Digestive, CHU CAEN Hôpital Côte de Nacre, Caen, France; Hospices Civils de Lyon, Lyon, France.
Background and aims: De novo malignancies are one of the major late complications and cause of death after liver transplantation (LT). Using extensive data from…
2018 American Transplant Congress
Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells
H. Zhou,¹ Z. Rao,¹ R. Liu,¹ S. Zhou,¹ J. Rao,¹ J. Gu,¹ H. Lu,¹ Y. Xia,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role and its underlying mechanism of Rictor/mTOR complex 2 (mTORC2)…
2018 American Transplant Congress
De Nove Malignancies after Liver Transplantation: Single Center Experience in Korea
Y. Yoon,¹ J. Lee,¹ Y. You,² D. Kim.²
¹Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea; ²Surgery, Seoul St.Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
IntroductionDe novo malignancies are one of the leading causes of late mortality after liver transplantation (LT). We analyze the clinical characteristics, prevalence, risk factors, prevention…
2018 American Transplant Congress
Is Percent Exception at Transplant a Driver of MELD Inflation?
D. Schladt,¹ J. Snyder,¹ A. Israni,¹ W. Kim,² J. Lake.³
¹SRTR, Minneapolis, MN; ²Stanford University, Stanford, CA; ³Univ of Minnesota, Minneapolis, MN.
Before 2016, the proportion of deceased donor liver recipients with an exception status at liver transplant (LT) correlated strongly with median MELD at transplant (MMaT)…
2018 American Transplant Congress
The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Recipients
V. Jucaud,¹ A. Shaked,² M. DesMarais,³ P. Sayre,³ M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²University of Pennsylvania, Philadelphia, PA; ³Immune Tolerance Network, Seattle, WA.
Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries.We studied the development of…
2018 American Transplant Congress
Predictive Value of mRECIST in HCC Response to the Neoadjuvant Locoregional Therapies and Prognosis Affected by the Peak AFP Level before Liver Transplantation
M. Xu,¹ T. Fraum,² S. Garcia-Aroz,¹ N. Vachharajani,¹ N. Saad,³ K. Fowler,² Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Department of Radiology, Washington University School of Medicine, St. Louis, MO; ³Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY.
PURPOSE: The modified response evaluation criteria in solid tumors (mRECIST) has been used to assess the response of hepatocellular carcinoma (HCC) to locoregional therapy (LRT)…
2018 American Transplant Congress
Liver Transplant Recipients with End-Stage Renal Disease Largely Benefit from Kidney Transplantation
W. Ju, Y. Tang, Q. Zhao, L. Jing, S. Huang, Z. Zhu, F. Ji, Z. Zhang, X. He, G. Chen, Z. Guo, D. Wang.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: The incidence of end-stage renal disease (ESRD) following liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood…
2018 American Transplant Congress
Outcomes of Liver Transplantation for Hepatic Epithelioid Hemangioendothelioma in the U.S. (2002-2015)
T. Bittermann,¹ S. Prenner,¹ P. Abt,² D. Goldberg.^1,3
¹Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA; ²Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA; ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare, malignant vascular tumor of the liver with high mortality if left untreated. Liver transplantation (LT) is potentially curative,…
2018 American Transplant Congress
HIV-Positive Donors to HIV-Positive Transplant Recipients: The Italian Experience
P. Grossi,¹ D. Dalla Gasperina,¹ A. Petrolo,¹ D. Lombardi,¹ M. Balsamo,¹ M. Moioli,² G. Travi,² M. Merli,² F. Ferla,² M. Tozzi,¹ L. De Carlis,² G. Carcano,¹ M. Puoti,² A. Nanni Costa.³
¹Medicine and Surgery, University of Insubria-ASST Sette Laghi, Varese, Italy; ²ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; ³Centro Nazionale Trapianti-ISS, Roma, Italy.
In order to expand the availability of organs for HIV-positive patients, successful transplantation of kidneys and livers from HIV-positive donors into selected HIV-positive recipients was…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…