Articles tagged "Liver transplantation"

2018 American Transplant Congress
Midodrine Associated with Increased Mortality on Liver Transplant Waitlist
J. Kalil, M. Hertl, E. Schadde, J. Poirier, N. Alvey, E. Chan.
General Surgery - Transplant, Rush University Medical Center, Chicago, IL.
Background:Midodrine is an alpha-1 agonist which induces arterial and venous vasoconstriction. It prevents symptomatic hypotension and is used for treatment of refractory ascites and hepatorenal…
2018 American Transplant Congress
Living Liver Donation is Safe in Donors Heterozygous for an alpha-1 Antitrypsin Gene Mutation
T. Bittermann,¹ L. Wood,² P. Abt,² A. Shaked,² K. Olthoff,² D. Goldberg.^1,3
¹Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA; ²Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA; ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Patients homozygous for an alpha-1 antitrypsin mutation, particularly the Pi*ZZ phenotype, develop cirrhosis and pulmonary emphysema. Those with a heterozygous phenotype are thought to have…
2018 American Transplant Congress
Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway
Q. Ye,^1,2 W. Liang,¹ Z. Zhong,¹ S. Ye,¹ B. Tang,¹ Q. Hu,¹ J. Liang,¹ Y. Wang.¹
¹Transplant Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; ²The 3rd Xiangya Hospital of Central South Unversity, Changsha, China.
Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
2018 American Transplant Congress
Safety of Antithymocyte Globulin Use in Donation after Circulatory Death (DCD) Liver Transplantation
D. Felix,¹ B. Geiger,¹ J. Descourouez,¹ M. Jorgenson,¹ B. Hanlon,² G. Leverson,² D. Foley.²
¹Department of Pharmacy, UW Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: Rabbit antithymocyte globulin (rATG) is commonly used for induction immunosuppression and treatment of rejection in solid organ transplantation. Previous work has shown that rATG…
2018 American Transplant Congress
The First Series of Ischemia-Free Liver Transplantation in Human
X. He,¹ Z. Guo,¹ S. Huang,¹ Q. Zhao,¹ Y. Tang,¹ Z. Zhang,¹ Z. Zhu,¹ W. Ju,¹ L. Yang,² G. Chen.¹
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: Ischemia and reperfusion injury (IRI) is known as an inevitable event leading to early and late graft failure. We have performed the first case…
2018 American Transplant Congress
Making Sense of Hepatitis B Reactivation Risk in Anti-HBc Antibody (Ab) Positive Liver Transplant Recipients
S. Leistman,¹ J. Melaragno,¹ M. Dokus,² B. Al-Judaibi,² T. Babu.³
¹Department of Pharmacy, University of Rochester Medical Center, Rochester, NY; ²Division of Transplantation, University of Rochester Medical Center, Rochester, NY; ³Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY.
Background: Limited data exists regarding the rates of reactivation of hepatitis B virus (HBV) in anti-HBc Ab positive orthotopic liver transplant (OLT) recipients. Protocols vary…
2018 American Transplant Congress
Donor Liver Apoptosis is Associated with Early Allograft Dysfunction and Short-Time Graft Survival after Liver Transplantation
Z. Guo, Z. Zhu, Y. Tang, S. Huang, Z. Zhang, X. He, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims The aim of the study was to determine whether donor liver apoptosis is predictive for early allograft dysfunction (EAD) and graft survival after liver…
2018 American Transplant Congress
Living Donor Liver Transplantation for Alcoholic Liver Disease: Data from the A2ALL Study
H. Braun, J. Dodge, J. Grab, S. Syed, G. Roll, C. Freise, J. Roberts, N. Ascher.
Surgery, University of California, San Francisco, San Francisco, CA.
The literature on living donor liver transplantation (LDLT) for alcoholic liver disease (ALD) is primarily from single Asian centers. We investigated LDLT outcomes for ALD…
2018 American Transplant Congress
Donor TM6SF2 rs58542926 Genotype is a Risk Factor for Liver Graft Steatosis
I. Mikova,¹ M. Neroldova,² J. Hubacek,² D. Dlouha,² L. Kolesar,³ M. Jirsa,² E. Honsova,⁴ E. Sticova,⁴ V. Lanska,⁵ J. Spicak,¹ P. Trunecka.¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ²Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ³Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Background & Aims: The rs58542926 c.449C>T (p.E167K) polymorphism in TM6SF2 (transmembrane 6 superfamily member 2) is one of genetic factors predisposing to nonalcoholic fatty liver…
2018 American Transplant Congress
Predictors of Graft Survival amongst Recipients of Liver Allografts with Prolonged Cold Ischemic Time (CIT)
J. Steggerda,¹ K. Kim,¹ D. Malinoski,² M. Bloom.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Surgery, Oregon Health Science University, Portland, OR.
Background: CIT is an independent risk factor for worse outcomes in liver transplantation (LT). Factors contributing to improved graft survival in organs with CIT ≥12…