Articles tagged "Liver transplantation"

2018 American Transplant Congress
Viability Outcomes for Donor Livers Discarded Due to Steatosis Following Extra-Corporeal Machine Perfusion of the Liver
Y. Boteon,^1,2 R. Laing,^1,2 D. Neil,² A. Schlegel,² J. Attard,^1,2 G. Reynold,¹ P. Muiesan,² D. Mirza,² S. Afford,¹ H. Mergental.²
¹National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; ²Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.
Background: Steatosis is the main reason for discarding donor livers worldwide. Ex-vivo machine perfusion offers superior preservation for marginal organs and permits viability testing during…
2018 American Transplant Congress
Long-Term Outcomes after Living Liver Donation: Analysis of National Data Base
S. Hong, N-.J. Yi, K. Yoon, J-.H. Cho, J-.M. Lee, H. Kim, K. Lee, K. Suh.
Surgery, Seoul National University College of Medicine, Seoul, Korea.
Background: Every year, more than 800 healthy people undergo hepatic resection for living liver donation in Korea. Although 27 years has passed since the first…
2018 American Transplant Congress
A Comparison of the Discard Rate in Hepatitis C Deceased Liver Donors between Two Eras, 2008-2013 and 2014-2017. A Single Organ Procurement Organization Experience
M. Nazzal,¹ G. Marklin,² O. Okoye,¹ Y. Kim,¹ R. Ouseph.¹
¹Abdominal Transplant, Saint Louis University, Saint Louis, MO; ²Mid America Transplant, Saint Louis, MO.
With the introduction of new hepatitis C medications in 2014 , there is a growing concern for an increase in the discard rate of hepatitis…
2018 American Transplant Congress
Intestinal Microbiome Diversity is Associated with Liver Disease Etiology and Predicts Post-Liver Transplant Mortality
E. Verna, M. Annavajhala, M. Nenad, R. Brown, S. Sullivan, G. Korakani, M. Gidins, S. Khan, A. Gomez-Simmonds, A-.C. Uhlemann.
Medicine, Columbia University, New York, NY.
Background: Dysbiosis of the intestinal microbiome is common among patients with decompensated liver disease and has been associated with disease progression as well as life-threatening…
2018 American Transplant Congress
Resuscitation and Viability Testing of Initially Declined Livers Using Sequential Hypo- and Normothermic Machine Perfusion with an Acellular Fluid
Y. de Vries,^1,2 A. Matton,^1,2 S. Karangwa,^1,2 M. Nijsten,³ R. de Kleine,² A. van den Berg,⁴ V. de Meijer,² P. Meyer,⁵ M. de Boer,² R. Porte.²
¹Surgical Research Laboratory, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; ²Section of HPB Surgery and Liver Transplantation, University Medical Center Groningen, Groningen, Netherlands; ³Department of Critical Care, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Anesthesiology, University Medical Center Groningen, Groningen, Netherlands.
While end-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) resuscitates mitochondria and reduces ischemia-reperfusion injury, normothermic machine perfusion (NMP) allows for ex-situ functional testing of donor…
2018 American Transplant Congress
Post Reperfusion Portal Flow Rate Impacts Liver Allograft and Patient Survival in Patients with Pre Transplant Portal Vein Thrombosis
M. Rizzari, M. Safwan, M. Sobolic, S. Nagai, R. Schilke, K. Collins, A. Yoshida, M. Abouljoud.
Henry Ford Transplant Institute, Henry Ford Health System, Detroit, MI.
Background: Pre-transplant (pretx) portal vein thrombosis (PVT) not only makes the technical aspect of liver transplantation more challenging, it also is known to affect outcomes.…
2018 American Transplant Congress
Liver Transplant Survival Index for Recipients with High MELD Score: A Model for Post-Transplant Survival in Severely Ill Patients
J. Steggerda,¹ M. Bloom,¹ C. Bresee,² D. Malinoski,³ A. Klein,¹ K. Kim.¹
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Biostatistics, Cedars-Sinai Medical Center, Los Angeles, CA; ³Surgery, Oregon Health Science University, Portland, OR.
Background: SHARE-35 prioritizes patients with MELD scores ≥35 for regional sharing of liver allografts. Because this policy incentivizes transplantation of sicker patients, this study examines…
2018 American Transplant Congress
Positive Relationship between Transplant Center Volume and Utilization of Hard to Place Liver Allografts after Late Declines
J. Knox,¹ H. Braun,¹ S. Syeed,¹ K. Halazun,² G. Roll.¹
¹Department of Transplant Surgery, UCSF, San Francisco, CA; ²Weill Cornell Medical Center, New York, NY.
Given ongoing waitlist mortality and the high rates of liver discard in the US we wanted to investigate late declines (LD), and very late declines…
2018 American Transplant Congress
Increased BMI is a Predictor of Early Post-Transplant Cardiac Events and Mortality
A. Mahgoub, S. Jackson, J. Lake, N. Lim.
Medicine, University of Minnesota, Minneapolis, MN; Transplant Information Services/ISR2, Fairview Health Services, Minneapolis, MN.
Background: Cardiac events (CVE) remain a significant source of morbidity in the early post-transplant(post-tx) period despite extensive evaluation prior to liver transplant(LT). It is important…
2018 American Transplant Congress
MELD-Na Score Based Liver Allocation: Hyponatremia is No Longer a Risk Factor for Waitlist Mortality
S. Nagai,¹ L. Chau,¹ M. Safwan,¹ R. Schilke,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ M. Abouljoud,¹ D. Moonka.²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Gastroenterology, Henry Ford Hospital, Detroit, MI.
Background: Hyponatremia is associated with an increased risk of liver transplant (LT) waitlist mortality. The aim of this study was to compare waitlist outcomes between…