Articles tagged "Liver transplantation"

2018 American Transplant Congress
The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Recipients
V. Jucaud,¹ A. Shaked,² M. DesMarais,³ P. Sayre,³ M. Everly.¹
¹Terasaki Research Institute, Los Angeles, CA; ²University of Pennsylvania, Philadelphia, PA; ³Immune Tolerance Network, Seattle, WA.
Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries.We studied the development of…
2018 American Transplant Congress
Predictive Value of mRECIST in HCC Response to the Neoadjuvant Locoregional Therapies and Prognosis Affected by the Peak AFP Level before Liver Transplantation
M. Xu,¹ T. Fraum,² S. Garcia-Aroz,¹ N. Vachharajani,¹ N. Saad,³ K. Fowler,² Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Department of Radiology, Washington University School of Medicine, St. Louis, MO; ³Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY.
PURPOSE: The modified response evaluation criteria in solid tumors (mRECIST) has been used to assess the response of hepatocellular carcinoma (HCC) to locoregional therapy (LRT)…
2018 American Transplant Congress
Liver Transplant Recipients with End-Stage Renal Disease Largely Benefit from Kidney Transplantation
W. Ju, Y. Tang, Q. Zhao, L. Jing, S. Huang, Z. Zhu, F. Ji, Z. Zhang, X. He, G. Chen, Z. Guo, D. Wang.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: The incidence of end-stage renal disease (ESRD) following liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood…
2018 American Transplant Congress
Outcomes of Liver Transplantation for Hepatic Epithelioid Hemangioendothelioma in the U.S. (2002-2015)
T. Bittermann,¹ S. Prenner,¹ P. Abt,² D. Goldberg.^1,3
¹Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA; ²Division of Transplant Surgery, University of Pennsylvania, Philadelphia, PA; ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Hepatic epithelioid hemangioendothelioma (HEHE) is a rare, malignant vascular tumor of the liver with high mortality if left untreated. Liver transplantation (LT) is potentially curative,…
2018 American Transplant Congress
HIV-Positive Donors to HIV-Positive Transplant Recipients: The Italian Experience
P. Grossi,¹ D. Dalla Gasperina,¹ A. Petrolo,¹ D. Lombardi,¹ M. Balsamo,¹ M. Moioli,² G. Travi,² M. Merli,² F. Ferla,² M. Tozzi,¹ L. De Carlis,² G. Carcano,¹ M. Puoti,² A. Nanni Costa.³
¹Medicine and Surgery, University of Insubria-ASST Sette Laghi, Varese, Italy; ²ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; ³Centro Nazionale Trapianti-ISS, Roma, Italy.
In order to expand the availability of organs for HIV-positive patients, successful transplantation of kidneys and livers from HIV-positive donors into selected HIV-positive recipients was…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…
2018 American Transplant Congress
Derivation and Prospective External Validation of Prediction Models for Acute Kidney Injury in Adult Liver Transplant Recipients
Q. Zhao,¹ Z. Guo,¹ M. Chen,¹ S. Ma,¹ J. Lin,⁴ C. Zhang,² M. Han,³ X. He.¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China; ²Department of Hepatobiliary Surgery, Guangdong General Hospital, Guangzhou, China; ³Organ Transplant Department, The Eastern Hospital of the First Affiliated Hospital of SYSU, Guangzhou, China; ⁴Department of Hepatobiliary Surgery, The Third People's Hospital of Shenzhen, Shenzhen, China.
BACKGROUND: Acute kidney injury (AKI) is common in patients after liver transplantation, and has a marked impact on the perioperative and long-term morbidity and mortality.…
2018 American Transplant Congress
The Effect of Donor-Recipient Gender Matches on Living Donor Liver Transplantation
J. Han, Y. You, H. Choi, B. Kwak, D. Kim.
Surgery, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
PurposeSome investigators reported that the donor-recipient gender mismatches influence on long-term graft survival after deceased donor liver transplantation. The aim of this study was to…
2018 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2a Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski,¹ H. Atkins,² M. Macarthur,¹ C. Anne Marie,² D. Grant,¹ C. Bredsen,² E. Renner,¹ L. Lilly,¹ N. Selzner,¹ O. Adeyi,¹ R. Smith,¹ S. Moshkelgosha,¹ A. Humar,¹ S. Juvet,¹ G. Levy.¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada; ²Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2018 American Transplant Congress
mTOR Inhibition with Everolimus in De Novo Living Donor Liver Transplantation – 24-Months Results from the H2307 Pivotal Trial
L. Jeng,¹ S. Lee,¹ A. Soin,¹ S. Uemoto,¹ D. Maluf,¹ J. Emond,¹ M. Meier,² J. Kochuparampil,² C. Sips,² S. Kaneko,³ G. Levy.¹
¹H2307 Study Group, Taichung, Taiwan; ²Novartis Pharma AG, Basel, Switzerland; ³Novartis Pharma KK, Tokyo, Japan.
Purpose: Everolimus (EVR) with reduced-dose tacrolimus (rTAC) has been shown to be efficacious in preventing graft rejection and improving renal function in deceased-donor liver transplant…